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Deoxyribonucleic acid (DNA) has shown great promise in enabling computational applications, most notably in the fields of DNA digital data storage and DNA computing. Information is encoded as DNA strands, which will naturally bind in…

Machine Learning · Computer Science 2021-10-22 David Buterez

Deep neural networks (DNNs) achieve state-of-the-art performance in many areas, including computer vision, system configuration, and question-answering. However, DNNs are expensive to develop, both in intellectual effort (e.g., devising new…

Software Engineering · Computer Science 2024-04-26 James C. Davis , Purvish Jajal , Wenxin Jiang , Taylor R. Schorlemmer , Nicholas Synovic , George K. Thiruvathukal

Density reconstruction from X-ray projections is an important problem in radiography with key applications in scientific and industrial X-ray computed tomography (CT). Often, such projections are corrupted by unknown sources of noise and…

Image and Video Processing · Electrical Eng. & Systems 2026-02-26 Siddhant Gautam , Marc L. Klasky , Balasubramanya T. Nadiga , Trevor Wilcox , Gary Salazar , Saiprasad Ravishankar

Standard deep neural networks (DNNs) are commonly trained in an end-to-end fashion for specific tasks such as object recognition, face identification, or character recognition, among many examples. This specificity often leads to…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Raphaël Achddou , J. Matias di Martino , Guillermo Sapiro

The synthesis of DNA strands remains the most costly part of the DNA storage system. Thus, to make DNA storage system more practical, the time and materials used in the synthesis process have to be optimized. We consider the most common…

Information Theory · Computer Science 2023-05-15 Johan Chrisnata , Han Mao Kiah , Van Long Phuoc Pham

The DNA storage channel is considered, in which the $M$ Deoxyribonucleic acid (DNA) molecules comprising each codeword are stored without order, sampled $N$ times with replacement, and then sequenced over a discrete memoryless channel. For…

Information Theory · Computer Science 2022-02-15 Nir Weinberger , Neri Merhav

Recently, deep learning-based compressed sensing (CS) has achieved great success in reducing the sampling and computational cost of sensing systems and improving the reconstruction quality. These approaches, however, largely overlook the…

Computer Vision and Pattern Recognition · Computer Science 2023-04-25 Yu Zhou , Yu Chen , Xiao Zhang , Pan Lai , Lei Huang , Jianmin Jiang

Diffraction drastically limits the bit density in optical data storage. To increase the storage density, alternative strategies involving supplementary recording dimensions and robust read-out schemes must be explored. Here, we propose to…

Applied Physics · Physics 2020-01-28 Peter R. Wiecha , Aurélie Lecestre , Nicolas Mallet , Guilhem Larrieu

DNA storage has emerged as a promising solution for large-scale and long-term data preservation. Among various error types, insertions are the most frequent errors occurring in DNA sequences, where the inserted symbol is often identical or…

Information Theory · Computer Science 2026-04-07 Hengfeng Liu , Chunming Tang , Cuiling Fan

In the emerging field of DNA storage, data is encoded as DNA sequences and stored. The data is read out again by sequencing the stored DNA. Nanopore sequencing is a new sequencing technology that has many advantages over other methods; in…

Information Theory · Computer Science 2021-02-04 Reyna Hulett , Shubham Chandak , Mary Wootters

Deep neural networks (DNNs) have achieved remarkable success across diverse domains, but their performance can be severely degraded by noisy or corrupted training data. Conventional noise mitigation methods often rely on explicit…

Machine Learning · Computer Science 2025-06-16 Deliang Jin , Gang Chen , Shuo Feng , Yufeng Ling , Haoran Zhu

Distant speech recognition is a challenge, particularly due to the corruption of speech signals by reverberation caused by large distances between the speaker and microphone. In order to cope with a wide range of reverberations in…

Computation and Language · Computer Science 2016-08-18 Jeehye Lee , Myungin Lee , Joon-Hyuk Chang

Convolutional Neural Networks (CNN) based image reconstruction methods have been intensely used for X-ray computed tomography (CT) reconstruction applications. Despite great success, good performance of this data-based approach critically…

Computer Vision and Pattern Recognition · Computer Science 2019-01-31 Ziling Wu , Abdulaziz Alorf , Ting Yang , Ling Li , Yunhui Zhu

In recent years numerous methods have been developed to formally verify the robustness of deep neural networks (DNNs). Though the proposed techniques are effective in providing mathematical guarantees about the DNNs behavior, it is not…

Machine Learning · Computer Science 2023-02-01 Debangshu Banerjee , Avaljot Singh , Gagandeep Singh

The R2D2 Deep Neural Network (DNN) series was recently introduced for image formation in radio interferometry. It can be understood as a learned version of CLEAN, whose minor cycles are substituted with DNNs. We revisit R2D2 on the grounds…

Instrumentation and Methods for Astrophysics · Physics 2025-10-02 Amir Aghabiglou , Chung San Chu , Chao Tang , Arwa Dabbech , Yves Wiaux

RNA can be used as a high-density medium for data storage and transmission; however, an important RNA process -- replication -- is noisy. This paper presents an error analysis for RNA as a data transmission medium, analyzing how deletion…

Emerging Technologies · Computer Science 2016-09-26 Andrew W. Eckford , Taro Furbayashi , Tadashi Nakano

Synthetic DNA approaches 227.5 exabytes per gram of storage density with stability over millennial timescales. Realising this capacity requires error-correction codes that recover data from substantial synthesis and sequencing errors.…

Information Theory · Computer Science 2026-04-23 James L. Banal

To increase the information capacity of DNA storage, composite DNA letters were introduced. We propose a novel channel model for composite DNA in which composite sequences are decomposed into ordered standard non-composite sequences. The…

Information Theory · Computer Science 2025-10-31 Besart Dollma , Ohad Elishco , Eitan Yaakobi

Because of its high data density and longevity, DNA is emerging as a promising candidate for satisfying increasing data storage needs. Compared to conventional storage media, however, data stored in DNA is subject to a wider range of errors…

Information Theory · Computer Science 2020-08-20 Yuanyuan Tang , Farzad Farnoud

DNA data storage systems encode digital data into DNA strands, enabling dense and durable storage. Efficient data retrieval depends on coverage depth, a key performance metric. We study the random access coverage depth problem and focus on…

Information Theory · Computer Science 2025-07-29 Şeyma Bodur , Stefano Lia , Hiram H. López , Rati Ludhani , Alberto Ravagnani , Lisa Seccia
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