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Quadratic programming (QP) is the most widely applied category of problems in nonlinear programming. Many applications require real-time/fast solutions, though not necessarily with high precision. Existing methods either involve matrix…

Machine Learning · Computer Science 2025-09-23 Ziang Chen , Xiaohan Chen , Jialin Liu , Xinshang Wang , Wotao Yin

In many operational contexts, solutions to NP-hard combinatorial optimization problems, modeled by means of Mixed-Integer Linear Programming (MILP), may become infeasible due to unpredictable disruptions. Typically, reoptimizing by solving…

Optimization and Control · Mathematics 2026-05-27 Mathieu Lerouge , Andrea Lodi , Enrico Malaguti , Michele Monaci , Filippo Focacci

Mixed Integer Linear Programs (MILP) are well known to be NP-hard (Non-deterministic Polynomial-time hard) problems in general. Even though pure optimization-based methods, such as constraint generation, are guaranteed to provide an optimal…

Optimization and Control · Mathematics 2022-07-18 Asunción Jiménez-Cordero , Juan Miguel Morales , Salvador Pineda

By exploiting the correlation between the structure and the solution of Mixed-Integer Linear Programming (MILP), Machine Learning (ML) has become a promising method for solving large-scale MILP problems. Existing ML-based MILP solvers…

Machine Learning · Computer Science 2025-01-03 Yixuan Li , Can Chen , Jiajun Li , Jiahui Duan , Xiongwei Han , Tao Zhong , Vincent Chau , Weiwei Wu , Wanyuan Wang

Uncertainty in surgery durations continues to be difficult to account for in operating room scheduling. In particular, it remains complex to accurately incorporate uncertainty in surgical overtime constraints within mixed-integer linear…

Optimization and Control · Mathematics 2026-04-29 Cindy Pistorius , J. Theresia van Essen

We transform join ordering into a mixed integer linear program (MILP). This allows to address query optimization by mature MILP solver implementations that have evolved over decades and steadily improved their performance. They offer…

Databases · Computer Science 2015-11-09 Immanuel Trummer , Christoph Koch

Over the past few decades, neuroscience experiments have become increasingly complex and naturalistic. Experimental design has in turn become more challenging, as experiments must conform to an ever-increasing diversity of design…

Neurons and Cognition · Quantitative Biology 2020-12-07 Storm Slivkoff , Jack L. Gallant

Mixed Integer Linear Programming (MILP) is a fundamental class of NP-hard problems that has garnered significant attention from both academia and industry. The Branch-and-Bound (B\&B) method is the dominant approach for solving MILPs and…

Machine Learning · Computer Science 2025-11-27 Tongkai Lu , Shuai Ma , Chongyang Tao

This paper deals with a distributed Mixed-Integer Linear Programming (MILP) set-up arising in several control applications. Agents of a network aim to minimize the sum of local linear cost functions subject to both individual constraints…

Optimization and Control · Mathematics 2021-02-12 Andrea Camisa , Ivano Notarnicola , Giuseppe Notarstefano

Binarized Neural Networks (BNNs) have recently attracted significant interest due to their computational efficiency. Concurrently, it has been shown that neural networks may be overly sensitive to "attacks" - tiny adversarial changes in the…

Machine Learning · Computer Science 2018-10-09 Elias B. Khalil , Amrita Gupta , Bistra Dilkina

In the past few years, there has been an explosive surge in the use of machine learning (ML) techniques to address combinatorial optimization (CO) problems, especially mixed-integer linear programs (MILPs). Despite the achievements, the…

Machine Learning · Computer Science 2024-03-12 Zijie Geng , Xijun Li , Jie Wang , Xiao Li , Yongdong Zhang , Feng Wu

We consider the problem of minimizing the makespan on batch processing identical machines, subject to compatibility constraints, where two jobs are compatible if they can be processed simultaneously in a same batch. These constraints are…

Discrete Mathematics · Computer Science 2023-09-07 Khaoula Bouakaz , Mourad Boudhar

Graph neural networks (GNNs), as the de-facto model class for representation learning on graphs, are built upon the multi-layer perceptrons (MLP) architecture with additional message passing layers to allow features to flow across nodes.…

Machine Learning · Computer Science 2023-08-07 Chenxiao Yang , Qitian Wu , Jiahua Wang , Junchi Yan

Recently, a novel two-phase framework named mol-infer for inference of chemical compounds with prescribed abstract structures and desired property values has been proposed. The framework mol-infer is primarily based on using mixed integer…

Machine Learning · Computer Science 2025-07-08 Jianshen Zhu , Naveed Ahmed Azam , Kazuya Haraguchi , Liang Zhao , Tatsuya Akutsu

Graph Neural Networks (GNNs) are popular for graph machine learning and have shown great results on wide node classification tasks. Yet, they are less popular for practical deployments in the industry owing to their scalability challenges…

Machine Learning · Computer Science 2022-03-24 Shichang Zhang , Yozen Liu , Yizhou Sun , Neil Shah

In this paper we deal with a network of agents seeking to solve in a distributed way Mixed-Integer Linear Programs (MILPs) with a coupling constraint (modeling a limited shared resource) and local constraints. MILPs are NP-hard problems and…

Systems and Control · Computer Science 2020-10-28 Andrea Camisa , Ivano Notarnicola , Giuseppe Notarstefano

In this paper, we investigate the constraint typology of mixed-integer linear programming MILP formulations. MILP is a commonly used mathematical programming technique for modelling and solving real-life scheduling, routing, planning,…

Artificial Intelligence · Computer Science 2021-03-02 Vicky Mak-Hau , John Yearwood , William Moran

Influence diagrams represent decision-making problems with interdependencies between random events, decisions, and consequences. Traditionally, they have been solved using algorithms that determine the expected utility-maximizing decision…

Optimization and Control · Mathematics 2026-01-14 Topias Terho , Fabricio Oliveira , Ahti Salo , Pedro Munari

This paper analyzes the integration of artificial intelligence (AI) with mixed integer linear programming (MILP) to address complex optimization challenges in air transportation with explainability. The study aims to validate the use of…

Mixed Integer Linear Programming (MILP) is a fundamental tool for modeling combinatorial optimization problems. Recently, a growing body of research has used machine learning to accelerate MILP solving. Despite the increasing popularity of…

Machine Learning · Computer Science 2024-10-29 Weimin Huang , Taoan Huang , Aaron M Ferber , Bistra Dilkina