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Measuring the amplitude and the absolute phase of a monochromatic microwave field at a specific point of space and time has many potential applications, including precise qubit rotations and wavelength quantum teleportation. Here we show…

Quantum Physics · Physics 2007-05-23 George C. Cardoso , Prabhakar Pradhan , Jacob Morzinski , M. S. Shahriar

Self-assembled monolayers (SAMs) of organic molecules are widely employed in surface chemistry and biology, and serve as ultra-fine lithographic resists. Due to their small thickness of only a few nanometers, the analysis of patterned…

Materials Science · Physics 2014-10-28 Hadas Alon , Idan Bakish , Josh Nehrer , Assaf Y. Anderson , Chaim N. Sukenik , Avi Zadok , Doron Naveh

In this work we present a refractive index sensor based on the leaky radiation of a microfiber. The 5.3um diameter microfiber is fabricated by drawing a commercial optical fiber. When the microfiber is immersed into a liquid with larger…

Optics · Physics 2014-05-20 F. Gao , H. Liu , C. Sheng , C. Zhu , S. N. Zhu

In the paper, we explain an automated LabVIEW controlled setup that enables interferometric measurements of refractive indices in crystalline materials using a laser light source. The setup combines a mechanical system, a…

Instrumentation and Detectors · Physics 2020-04-06 Nazariy Andrushchak , Ivan Karbovnyk

Microcavity and whispering gallery mode (WGM) biosensors derive their sensitivity from monitoring frequency shifts induced by protein binding at sites of highly confined field intensities, where field strengths can be further amplified by…

Super-resolution localization microscopy is based on determining the positions of individual fluorescent markers in a sample. The major challenge in reaching an ever higher localization precision lies in the limited number of collected…

Optics · Physics 2020-08-05 Daniel Böning , Franz-Ferdinand Wieser , Vahid Sandoghdar

Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal…

Optics · Physics 2021-08-11 Celalettin Yurdakul , Haonan Zong , Yeran Bai , Ji-Xin Cheng , M. Selim Unlu

IR absorption spectroscopy of hemoglobin was performed using an IR optical parametric oscillator laser and a commercial atomic force microscope in a novel experimental arrangement based on the use of a bottom-up excitation alignment. This…

Biological Physics · Physics 2010-10-29 Fiona Yarrow , James H. Rice

We demonstrate a smart laser-diffraction analysis technique for particle mixture identification. We retrieve information about the size, geometry, and ratio concentration of two-component heterogeneous particle mixtures with an efficiency…

Image and Video Processing · Electrical Eng. & Systems 2022-02-03 Arturo Villegas , Mario A. Quiroz-Juarez , Alfred U'Ren , Juan P. Torres , Roberto de J. Leon-Montiel

We propose the use of an optically trapped, dye doped polystyrene microsphere for spatial probing of the refractive index at any position in a fluid. We demonstrate the use of the dye embedded in the microsphere as an internal broadband…

Optics · Physics 2015-06-26 P. Zijlstra , K. L. van der Molen , A. P. Mosk

Reliably distinguishing between cells based on minute differences in receptor density is crucial for cell-cell or virus-cell recognition, the initiation of signal transduction and selective targeting in directed drug delivery. Such sharp…

Soft Condensed Matter · Physics 2021-10-04 Christine Linne , Daniele Visco , Stefano Angioletti-Uberti , Liedewij Laan , Daniela J. Kraft

Digital holographic microscopy is a thriving imaging modality that attracted considerable research interest in quantitative biological cell imaging due to its ability to not only create excellent label-free contrast, but also supply…

Optics · Physics 2019-04-03 Gili Dardikman , Natan T. Shaked

We demonstrate single-pixel imaging in the spectral domain by encoding Fourier probe patterns onto the spectrum of a superluminescent laser diode using a programmable optical filter. As a proof-of-concept, we measure the…

Optics · Physics 2020-02-26 Piotr Ryczkowski , Caroline Amiot , John M. Dudley , Goery Genty

In the realm of healthcare, label-free sensing is a vital component for various applications. Micro-photonic technology presents a promising avenue to pursue pivotal goals. With the use of this technology, healthcare professionals and…

Optics · Physics 2024-04-24 Giuseppina Simone

Coating thickness measurement and inspection of defects beneath optically opaque surfaces are among the most promising commercial applications of the terahertz (THz) imaging technology. However, there are two main sources of complexity in…

Applied Physics · Physics 2025-05-14 Arash Karimi , Zachery B. Harris , Erica Heller , Paul Vahey , M. Hassan Arbab

We developed a novel method based on the Fourier analysis of protein molecular surfaces to speed up the analysis of the vast structural data generated in the post-genomic era. This method computes the power spectrum of surfaces of the…

Quantitative Methods · Quantitative Biology 2015-09-18 C. Sofia Carvalho , Dimitrios Vlachakis , Georgia Tsiliki , Vasileios Megalooikonomou , Sophia Kossida

The detachment of a semi-ordered monolayer of polystyrene microspheres adhered to an aluminum-coated glass substrate is studied using a laser-induced spallation technique. The microsphere-substrate adhesion force is estimated from substrate…

Mesoscale and Nanoscale Physics · Physics 2016-03-22 Morgan Hiraiwa , Melicent Stossel , Amey Khanolkar , Junlan Wang , Nicholas Boechler

We describe here how to apply the three dimensional imaging technique of refrecative index matched scanning to hydrogel spheres. Hydrogels are water based materials with a low refractive index, which allows for index matching with…

Soft Condensed Matter · Physics 2018-10-22 Joshua A. Dijksman , Nicolas Brodu , R. P. Behringer

Optical microcavity enhanced light-matter interaction offers a powerful tool to develop fast and precise sensing techniques, spurring applications in the detection of biochemical targets ranging from cells, nanoparticles, and large…

Hyperspectroscopy is a new method of surface image taking, providing simultaneously high position and spectral resolutions which allow one to make some conclusions about chemical compositions of the surfaces. We are now studying…

Instrumentation and Detectors · Physics 2016-11-18 I. Rodionov , J-M. Bidault , I. Crotty , P. Fonte , F. Galy , V. Peskov , O. Zanette