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Schemes for X-ray imaging single protein molecules using new x-ray sources, like x-ray free electron lasers (XFELs), require processing many frames of data that are obtained by taking temporally short snapshots of identical molecules, each…

Data Analysis, Statistics and Probability · Physics 2015-06-17 Kartik Ayyer , Hugh T. Philipp , Mark W. Tate , Veit Elser , Sol M. Gruner

The usually reported pixel resolution of single pixel imaging (SPI) varies between $32 \times 32$ and $256 \times 256$ pixels falling far below imaging standards with classical methods. Low resolution results from the trade-off between the…

Optics · Physics 2022-06-22 Rafał Stojek , Anna Pastuszczak , Piotr Wróbel , Rafał Kotyński

Single-shot X-ray imaging of short-lived nanostructures such as clusters and nanoparticles near a phase transition or non-crystalizing objects such as large proteins and viruses is currently the most elegant method for characterizing their…

Atomic and Molecular Clusters · Physics 2020-10-14 Thomas Stielow , Robin Schmidt , Christian Peltz , Thomas Fennel , Stefan Scheel

Single-pixel imaging (SPI) has offered an unprecedented technique for capturing a targeted scenes without requiring either raster-scanned systems or muti-pixel detectors. However, in the current research, there are rare study reports about…

The current state of the art in structural biology is led by NMR, X-ray crystallography and TEM investigations. These powerful tools however all rely on averaging over a large ensemble of molecules. Here, we present an alternative concept…

Atomic and Molecular Clusters · Physics 2015-12-15 Tatiana Latychevskaia , Jean-Nicolas Longchamp , Conrad Escher , Hans-Werner Fink

The mode of action of proteins is to a large extent given by their ability to adopt different conformations. This is why imaging single biomolecules at atomic resolution is one of the ultimate goals of biophysics and structural biology. The…

Biological Physics · Physics 2012-09-27 Jean-Nicolas Longchamp , Tatiana Latychevskaia , Conrad Escher , Hans-Werner Fink

Single-pixel imaging (SPI) exhibits cost-effectiveness, broad spectrum, and stable sub-Nyquist sampling reconstruction, enabling applications across diverse imaging fields.However, due to the inherent reconstruction mechanism, SPI is not…

Optics · Physics 2025-04-18 Shao Chongwu , Cao Yue , Zhao Qing , Yao Xuri

The routine atomic-resolution structure determination of single particles is expected to have profound implications for probing the structure-function relationship in systems ranging from energy materials to biological molecules.…

Single-pixel imaging, originally developed in light optics, facilitates fast three-dimensional sample reconstruction, as well as probing with light wavelengths undetectable by conventional multi-pixel detectors. However, the spatial…

HoloTile is a patented computer generated holography approach with the aim of reducing the speckle noise caused by the overlap of the non-trivial physical extent of the point spread function in Fourier holographic systems from adjacent…

Optics · Physics 2024-02-16 Jesper Glückstad , Andreas Erik Gejl Madsen

We develop a novel algorithm for large-scale holographic reconstruction of 3D particle fields. Our method is based on a multiple-scattering beam propagation method (BPM) combined with sparse regularization that enables recovering dense 3D…

Optics · Physics 2021-05-24 Hao Wang , Waleed Tahir , Jiabei Zhu , Lei Tian

The structure and dynamics of isolated nanosamples in free flight can be directly visualized via single-shot coherent diffractive imaging using the intense and short pulses of X-ray free-electron lasers. Wide-angle scattering images even…

Single-pixel imaging (SPI) offers a cost-effective route to hyperspectral acquisition but struggles to recover high-fidelity spatial and spectral details under extremely low sampling rates, a severely ill-posed inverse problem. While deep…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Hao Zhang , Bilige Xu , Lichen Wei , Xu Ma , Wenyi Ren

A new algorithmic framework is presented for holographic phase retrieval via maximum likelihood optimization, which allows for practical and robust image reconstruction. This framework is especially well-suited for holographic coherent…

Image and Video Processing · Electrical Eng. & Systems 2022-02-18 David A. Barmherzig , Ju Sun

Single particle cryo-electron microscopy has become a critical tool in structural biology over the last decade, able to achieve atomic scale resolution in three dimensional models from hundreds of thousands of (noisy) two-dimensional…

Numerical Analysis · Mathematics 2023-07-19 Aaditya V. Rangan , Leslie Greengard

Pattern recognition and image classification are essential tasks in machine vision. Autonomous vehicles, for example, require being able to collect the complex information contained in a changing environment and classify it in real time.…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Aisha Kanwal , Graeme E. Johnstone , Fahimeh Dehkhoda , Johannes H. Herrnsdorf , Robert K. Henderson , Martin D. Dawson , Xavier Porte , Michael J. Strain

Single-pixel imaging (SPI) is a novel technique capturing 2D images using a photodiode, instead of conventional 2D array sensors. SPI owns high signal-to-noise ratio, wide spectrum range, low cost, and robustness to light scattering.…

Computer Vision and Pattern Recognition · Computer Science 2017-12-12 Liheng Bian , Jinli Suo , Qionghai Dai , Feng Chen

X-ray Free Electron Lasers (XFEL) are revolutionary photons sources, whose ultrashort, brilliant pulses are expected to allow single molecule diffraction experiments providing structural information on the atomic length scale. This ultimate…

Optics · Physics 2015-05-20 Andrea Fratalocchi , Giancarlo Ruocco

The spatial structure of single photons is becoming an extensively explored resource used for facilitating the free-space quantum key distribution and quantum computation as well as for benchmarking the limits of quantum entanglement…

Quantum Physics · Physics 2016-11-08 Radosław Chrapkiewicz , Michał Jachura , Konrad Banaszek , Wojciech Wasilewski