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We study functional activity in the human brain using functional Magnetic Resonance Imaging and recently developed tools from network science. The data arise from the performance of a simple behavioural motor learning task. Unsupervised…

We introduce principal differences analysis (PDA) for analyzing differences between high-dimensional distributions. The method operates by finding the projection that maximizes the Wasserstein divergence between the resulting univariate…

Machine Learning · Statistics 2017-05-03 Jonas Mueller , Tommi Jaakkola

Continual learning in neural networks suffers from a phenomenon called catastrophic forgetting, in which a network quickly forgets what was learned in a previous task. The human brain, however, is able to continually learn new tasks and…

Machine Learning · Computer Science 2022-10-07 Tananun Songdechakraiwut , Xiaoshuang Yin , Barry D. Van Veen

Persistent homology is an area within topological data analysis (TDA) that can uncover different dimensional holes (connected components, loops, voids, etc.) in data. The holes are characterized, in part, by how long they persist across…

Methodology · Statistics 2025-04-08 Sixtus Dakurah , Jessi Cisewski-Kehe

The formation of transient networks in response to external stimuli or as a reflection of internal cognitive processes is a hallmark of human brain function. However, its identification in fMRI data of the human brain is notoriously…

Neurons and Cognition · Quantitative Biology 2016-12-05 Gabriele Lohmann , Johannes Stelzer , Verena Zuber , Tilo Buschmann , Daniel Margulies , Andreas Bartels , Klaus Scheffler

We use topological data analysis to study "functional networks" that we construct from time-series data from both experimental and synthetic sources. We use persistent homology with a weight rank clique filtration to gain insights into…

Quantitative Methods · Quantitative Biology 2017-05-24 Bernadette J. Stolz , Heather A. Harrington , Mason A. Porter

High-dimensional data often exhibit hierarchical structures in both modes: samples and features. Yet, most existing approaches for hierarchical representation learning consider only one mode at a time. In this work, we propose an…

Machine Learning · Computer Science 2025-10-23 Ya-Wei Eileen Lin , Ronald R. Coifman , Gal Mishne , Ronen Talmon

Network science has become an essential interdisciplinary tool for understanding complex biological systems. However, because these systems undergo continuous, often stimulus-driven changes in both structure and function, traditional static…

Molecular Networks · Quantitative Biology 2025-05-19 Abir Khazaal , Fatemeh Vafaee

Brain network provides important insights for the diagnosis of many brain disorders, and how to effectively model the brain structure has become one of the core issues in the domain of brain imaging analysis. Recently, various computational…

Neurons and Cognition · Quantitative Biology 2022-12-02 Zhengwang Xia , Tao Zhou , Saqib Mamoon , Amani Alfakih , Jianfeng Lu

Persistent homology (PH) is a method used in topological data analysis (TDA) to study qualitative features of data that persist across multiple scales. It is robust to perturbations of input data, independent of dimensions and coordinates,…

Algebraic Topology · Mathematics 2017-09-13 Nina Otter , Mason A. Porter , Ulrike Tillmann , Peter Grindrod , Heather A. Harrington

In this paper, we develop topological data analysis methods for classification tasks on univariate time series. As an application, we perform binary and ternary classification tasks on two public datasets that consist of physiological…

Machine Learning · Statistics 2021-06-15 Alperen Karan , Atabey Kaygun

Spatial relationships in multi-species data can indicate and affect system outcomes and behaviors, ranging from disease progression in cancer to coral reef resilience in ecology; therefore, quantifying these relationships is an important…

Graph Neural Networks (GNNs) are widely used for node classification tasks but often fail to generalize when training and test nodes come from different distributions, limiting their practicality. To overcome this, recent approaches adopt…

Machine Learning · Computer Science 2024-06-04 Weihuang Zheng , Jiashuo Liu , Jiaxing Li , Jiayun Wu , Peng Cui , Youyong Kong

Understanding the structure of the brain, and how it changes with time and disease, is a core goal of structural neuroimaging. Contemporary approaches to structural brain analysis are dominated by voxel-wise, mass-univariate methods such as…

Algebraic Topology · Mathematics 2026-04-28 Donato Quiccione , Mariam Pirashvili , Nathan Broomhead , Sean J. Fallon

Topological data analysis has recently been applied to the study of dynamic networks. In this context, an algorithm was introduced and helps, among other things, to detect early warning signals of abnormal changes in the dynamic network…

Algebraic Topology · Mathematics 2022-10-18 Bouchaib Azamir , Driss Bennis , Bertrand Michel

In this paper, we introduce the persistence transformation, a novel methodology in Topological Data Analysis (TDA) for applications in time series data which can be obtained in various areas such as science, politics, economy, healthcare,…

Algebraic Topology · Mathematics 2024-01-31 Gideon Klaila , Anastasios Stefanou , Lena Ranke

Understanding brain dynamics through functional Magnetic Resonance Imaging (fMRI) remains a fundamental challenge in neuroscience, particularly in capturing how the brain transitions between various functional states. Recently,…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Yanwu Yang , Thomas Wolfers

Now that disease-modifying therapies for Alzheimer disease have been approved by regulatory agencies, the early, objective, and accurate clinical diagnosis of AD based on the lowest-cost measurement modalities possible has become an…

Image and Video Processing · Electrical Eng. & Systems 2025-11-13 Faisal Ahmed , Taymaz Akan , Fatih Gelir , Owen T. Carmichael , Elizabeth A. Disbrow , Steven A. Conrad , Mohammad A. N. Bhuiyan

Topological data analysis (TDA) is a rising field in the intersection of mathematics, statistics, and computer science/data science. The cornerstone of TDA is persistent homology, which produces a summary of topological information called a…

Computational Geometry · Computer Science 2022-05-24 Yu-Min Chung , Michael Hull , Austin Lawson , Neil Pritchard

Time-delay embedding is a fundamental technique in Topological Data Analysis (TDA) for reconstructing the phase space dynamics of time-series data. Persistent homology effectively identifies global topological features, such as loops…

Statistics Theory · Mathematics 2026-04-21 Donghyun Park , Junhyun An , Taehyoung Kim , Jisu Kim
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