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Decision support systems based on clinical notes have the potential to improve patient care by pointing doctors towards overseen risks. Predicting a patient's outcome is an essential part of such systems, for which the use of deep neural…

Computation and Language · Computer Science 2021-12-01 Betty van Aken , Sebastian Herrmann , Alexander Löser

Doctors often rely on their past experience in order to diagnose patients. For a doctor with enough experience, almost every patient would have similarities to key cases seen in the past, and each new patient could be viewed as a mixture of…

Artificial Intelligence · Computer Science 2018-09-12 Ramin Moghaddass , Cynthia Rudin

Prototypical-part models are a popular interpretable alternative to black-box deep learning models for computer vision. However, they are difficult to train, with high sensitivity to hyperparameter tuning, inhibiting their application to…

Computer Vision and Pattern Recognition · Computer Science 2024-06-24 Frank Willard , Luke Moffett , Emmanuel Mokel , Jon Donnelly , Stark Guo , Julia Yang , Giyoung Kim , Alina Jade Barnett , Cynthia Rudin

Despite recent advances in machine learning and explainable AI, a gap remains in personalized preventive healthcare: predictions, interventions, and recommendations should be both understandable and verifiable for all stakeholders in the…

Clinical trials are a systematic endeavor to assess the safety and efficacy of new drugs or treatments. Conducting such trials typically demands significant financial investment and meticulous planning, highlighting the need for accurate…

Machine Learning · Computer Science 2025-11-03 Tien Huu Do , Antoine Masquelier , Nae Eoun Lee , Jonathan Crowther

We propose a novel inherently interpretable machine learning method that bases decisions on few relevant examples that we call prototypes. Our method, ProtoAttend, can be integrated into a wide range of neural network architectures…

Machine Learning · Computer Science 2019-09-27 Sercan O. Arik , Tomas Pfister

Recent applications of deep convolutional neural networks in medical imaging raise concerns about their interpretability. While most explainable deep learning applications use post hoc methods (such as GradCAM) to generate feature…

Computer Vision and Pattern Recognition · Computer Science 2023-04-17 Yuanyuan Wei , Roger Tam , Xiaoying Tang

Prototypical networks aim to build intrinsically explainable models based on the linear summation of concepts. Concepts are coherent entities that we, as humans, can recognize and associate with a certain object or entity. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Hugues Turbé , Mina Bjelogrlic , Gianmarco Mengaldo , Christian Lovis

Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently for patient phenotyping. Patient phenotyping is a classification task for determining whether a patient has a medical…

We combine concept-based neural networks with generative, flow-based classifiers into a novel, intrinsically explainable, exactly invertible approach to supervised learning. Prototypical neural networks, a type of concept-based neural…

Machine Learning · Computer Science 2024-07-18 Zachariah Carmichael , Timothy Redgrave , Daniel Gonzalez Cedre , Walter J. Scheirer

While interpretable prototype networks offer compelling case-based reasoning for clinical diagnostics, their raw continuous outputs lack the semantic structure required for medical documentation. Bridging this gap via standard…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Alvaro Lopez Pellicer , Plamen Angelov , Marwan Bukhari , Yi Li , Eduardo Soares , Jemma Kerns

Interpretability is a key requirement for the use of machine learning models in high-stakes applications, including medical diagnosis. Explaining black-box models mostly relies on post-hoc methods that do not faithfully reflect the model's…

Artificial Intelligence · Computer Science 2024-06-25 Kerol Djoumessi , Bubacarr Bah , Laura Kühlewein , Philipp Berens , Lisa Koch

In meta-learning approaches, it is difficult for a practitioner to make sense of what kind of representations the model employs. Without this ability, it can be difficult to both understand what the model knows as well as to make meaningful…

Machine Learning · Computer Science 2022-04-05 Pedro Sandoval-Segura , Wallace Lawson

An integrated approach is proposed across visual and textual data to both determine and justify a medical diagnosis by a neural network. As deep learning techniques improve, interest grows to apply them in medical applications. To enable a…

Machine Learning · Computer Science 2019-07-15 Graham Spinks , Marie-Francine Moens

Intensive Care Unit (ICU) mortality prediction, which estimates a patient's mortality status at discharge using EHRs collected early in an ICU admission, is vital in critical care. For this task, predictive accuracy alone is insufficient;…

Machine Learning · Computer Science 2025-10-15 Qingwen Li , Xiaohang Zhao , Xiao Han , Hailiang Huang , Lanjuan Liu

Deep learning has made significant progress in the past decade, and demonstrates potential to solve problems with extensive social impact. In high-stakes decision making areas such as law, experts often require interpretability for…

Computation and Language · Computer Science 2023-05-29 Chu Fei Luo , Rohan Bhambhoria , Samuel Dahan , Xiaodan Zhu

We present ProtoViT, a method for interpretable image classification combining deep learning and case-based reasoning. This method classifies an image by comparing it to a set of learned prototypes, providing explanations of the form ``this…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Chiyu Ma , Jon Donnelly , Wenjun Liu , Soroush Vosoughi , Cynthia Rudin , Chaofan Chen

The rapid growth of user-generated text across digital platforms has intensified the need for interpretable models capable of fine-grained text classification and explanation. Existing prototype-based models offer intuitive explanations but…

Artificial Intelligence · Computer Science 2026-05-19 Utsav Kumar Nareti , Suraj Kumar , Soumya Pandey , Soumi Chattopadhyay , Chandranath Adak , Sankha Subhra Mullick

Despite the success of deep learning in dermoscopy image analysis, its inherent black-box nature hinders clinical trust, motivating the use of prototypical networks for case-based visual transparency. However, inevitable selection bias in…

Image and Video Processing · Electrical Eng. & Systems 2026-03-02 Junhao Jia , Yueyi Wu , Huangwei Chen , Haodong Jing , Haishuai Wang , Jiajun Bu , Lei Wu

Deep neural network models have been proven to be very successful in image classification tasks, also for medical diagnosis, but their main concern is its lack of interpretability. They use to work as intuition machines with high…

Machine Learning · Computer Science 2019-04-26 Jordi de la Torre , Aida Valls , Domenec Puig