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Causal mediation analysis seeks to investigate how the treatment effect of an exposure on outcomes is mediated through intermediate variables. Although many applications involve longitudinal data, the existing methods are not directly…

Applications · Statistics 2021-02-24 Shuxi Zeng , Stacy Rosenbaum , Elizabeth Archie , Susan Alberts , Fan Li

Methods for automated discovery of causal relationships from non-interventional data have received much attention recently. A widely used and well understood model family is given by linear acyclic causal models (recursive structural…

Machine Learning · Statistics 2012-05-14 Patrik O. Hoyer , Antti Hyttinen

Analyzing multivariate count data generated by high-throughput sequencing technology in microbiome research studies is challenging due to the high-dimensional and compositional structure of the data and overdispersion. In practice,…

Applications · Statistics 2023-11-03 Jingyan Fu , Matthew D. Koslovsky , Andreas M. Neophytou , Marina Vannucci

This paper introduces the \proglang{R} package \pkg{meta4diag} for implementing Bayesian bivariate meta-analyses of diagnostic test studies. Our package \pkg{meta4diag} is a purpose-built front end of the \proglang{R} package \pkg{INLA}.…

Applications · Statistics 2016-07-08 Jingyi Guo , Andrea Riebler

During the past few years, mediation analysis has gained increasing popularity across various research fields. The primary objective of mediation analysis is to examine the direct impact of exposure on outcome, as well as the indirect…

Computation · Statistics 2023-05-18 Haixiang Zhang , Xin Li

Mendelian randomization (MR) is a pivotal tool in genetics, genomics, and epidemiology, leveraging genetic variants as instrumental variables to infer causal relationships between exposures and outcomes. Traditional MR methods, while…

Methodology · Statistics 2026-01-15 Bitan Sarkar , Yuchao Jiang , Tian Ge , Yang Ni

We consider mediated effects of an exposure, X on an outcome, Y, via a mediator, M, under no unmeasured confounding assumptions in the setting where models for the conditional expectation of the mediator and outcome are partially linear. We…

Methodology · Statistics 2025-01-08 Oliver Hines , Stijn Vansteelandt , Karla Diaz-Ordaz

Mixed-effects models are fundamental tools for analyzing clustered and repeated-measures data, but existing high-dimensional methods largely focus on penalized estimation with vector-valued covariates. Bayesian alternatives in this regime…

Methodology · Statistics 2026-02-24 Sreya Sarkar , Kshitij Khare , Sanvesh Srivastava

Bayesian causal inference offers a principled approach to policy evaluation of proposed interventions on mediators or time-varying exposures. We outline a general approach to the estimation of causal quantities for settings with…

Methodology · Statistics 2019-02-28 Leah Comment , Brent A. Coull , Corwin Zigler , Linda Valeri

Multimodal learning integrates diverse modalities but suffers from modality imbalance, where dominant modalities suppress weaker ones due to inconsistent convergence rates. Existing methods predominantly rely on static modulation or…

Machine Learning · Computer Science 2026-02-11 Zhaocheng Liu , Zhiwen Yu , Xiaoqing Liu

We introduce causal inference reasoning to cross-over trials, with a focus on Thorough QT (TQT) studies. For such trials, we propose different sets of assumptions and consider their impact on the modelling strategy and estimation procedure.…

Methodology · Statistics 2022-05-31 Jeppe Ekstrand Halkjær Madsen , Thomas Scheike , Christian Pipper

In spite of the diverse literature on nonstationary spatial modeling and approximate Gaussian process (GP) methods, there are no general approaches for conducting fully Bayesian inference for moderately sized nonstationary spatial data sets…

Computation · Statistics 2020-07-01 Mark D. Risser , Daniel Turek

Graphical models provide powerful tools to uncover complicated patterns in multivariate data and are commonly used in Bayesian statistics and machine learning. In this paper, we introduce the R package BDgraph which performs Bayesian…

Machine Learning · Statistics 2019-05-14 Reza Mohammadi , Ernst C. Wit

This paper asks whether integrating multimodal EEG and fMRI data offers a better characterisation of functional brain architectures than either modality alone. This evaluation rests upon a dynamic causal model that generates both EEG and…

Quantitative Methods · Quantitative Biology 2019-06-19 Huilin Wei , Amirhossein Jafarian , Peter Zeidman , Vladimir Litvak , Adeel Razi , Dewen Hu , Karl J. Friston

Long-sequence causal reasoning seeks to uncover causal relationships within extended time series data but is hindered by complex dependencies and the challenges of validating causal links. To address the limitations of large-scale language…

Computation and Language · Computer Science 2025-01-03 Yuxuan Zhang , Yulong Li , Zichen Yu , Feilong Tang , Zhixiang Lu , Chong Li , Kang Dang , Jionglong Su

We present GO-CBED, a goal-oriented Bayesian framework for sequential causal experimental design. Unlike conventional approaches that select interventions aimed at inferring the full causal model, GO-CBED directly maximizes the expected…

Machine Learning · Computer Science 2025-07-11 Zheyu Zhang , Jiayuan Dong , Jie Liu , Xun Huan

Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways…

Methodology · Statistics 2025-06-26 Tianchen Qian

In this dissertation the practical speech emotion recognition technology is studied, including several cognitive related emotion types, namely fidgetiness, confidence and tiredness. The high quality of naturalistic emotional speech data is…

Sound · Computer Science 2017-09-28 Chengwei Huang

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

Methodology · Statistics 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

Repetitive Transcranial Magnetic Stimulation (rTMS) is a well-supported, evidence-based treatment for depression. However, patterns of response to this treatment are inconsistent. Emerging evidence suggests that artificial intelligence can…

Machine Learning · Computer Science 2024-04-29 Matthew Squires , Xiaohui Tao , Soman Elangovan , Raj Gururajan , Haoran Xie , Xujuan Zhou , Yuefeng Li , U Rajendra Acharya