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Quantum annealing algorithms belong to the class of metaheuristic tools, applicable for solving binary optimization problems. Hardware implementations of quantum annealing, such as the quantum annealing machines produced by D-Wave Systems,…

Quantum Physics · Physics 2017-09-18 Florian Neukart , David Von Dollen , Christian Seidel , Gabriele Compostella

Feature selection is a machine learning technique for identifying relevant variables in classification and regression models. In single-cell RNA sequencing (scRNA-seq) data analysis, feature selection is used to identify relevant genes that…

Genomics · Quantitative Biology 2025-12-02 Selim Romero , Shreyan Gupta , Victoria Gatlin , Robert S. Chapkin , James J. Cai

Quantum computing offers significant potential for solving NP-hard combinatorial (optimization) problems that are beyond the reach of classical computers. One way to tap into this potential is by reformulating combinatorial problems as a…

Anomaly detection is a crucial task in machine learning that involves identifying unusual patterns or events in data. It has numerous applications in various domains such as finance, healthcare, and cybersecurity. With the advent of quantum…

Quantum Physics · Physics 2023-11-07 Julien Mellaerts

Satellite image acquisition scheduling is a problem that is omnipresent in the earth observation field; its goal is to find the optimal subset of images to be taken during a given orbit pass under a set of constraints. This problem, which…

Quantum annealers are suited to solve several logistic optimization problems expressed in the QUBO formulation. However, the solutions proposed by the quantum annealers are generally not optimal, as thermal noise and other disturbing…

Quantum Physics · Physics 2024-05-21 Claudio Sanavio , Edoardo Tignone , Elisa Ercolessi

A range of quantum algorithms, especially those leveraging variational parameterization and circuit-based optimization, are being studied as alternatives for solving classically intractable combinatorial optimization problems (COPs).…

Quantum Physics · Physics 2025-06-18 Monit Sharma , Hoong Chuin Lau

Quantum annealers, such as the device built by D-Wave Systems, Inc., offer a way to compute solutions of NP-hard problems that can be expressed in Ising or QUBO (quadratic unconstrained binary optimization) form. Although such solutions are…

Quantum Physics · Physics 2022-10-27 Aaron Barbosa , Elijah Pelofske , Georg Hahn , Hristo N. Djidjev

Recent advances in the development of commercial quantum annealers such as the D-Wave 2X allow solving NP-hard optimization problems that can be expressed as quadratic unconstrained binary programs. However, the relatively small number of…

Quantum Physics · Physics 2018-02-01 Georg Hahn , Hristo N. Djidjev

We present a quantum annealing-based solution method for topology optimization (TO). In particular, we consider TO in a more general setting, i.e., applied to structures of continuum domains where designs are represented as distributed…

Numerical Analysis · Mathematics 2023-01-30 Zisheng Ye , Xiaoping Qian , Wenxiao Pan

Recent developments in quantum annealing techniques have been indicating potential advantage of quantum annealing for solving NP-hard optimization problems. In this article we briefly indicate and discuss the beneficial features of quantum…

Statistical Mechanics · Physics 2015-06-22 Sudip Mukherjee , Bikas K. Chakrabarti

The recent availability of the first commercial quantum computers has provided a promising tool to tackle NP hard problems which can only be solved heuristically with present techniques. However, it is unclear if the current state of…

Quantum Physics · Physics 2018-02-01 Hristo N. Djidjev , Guillaume Chapuis , Georg Hahn , Guillaume Rizk

Molecular docking is a crucial phase in drug discovery, involving the precise determination of the optimal spatial arrangement between two molecules when they bind. The such analysis, the 3D structure of molecules is a fundamental…

Quantum Physics · Physics 2024-03-04 Arit Kumar Bishwas , Arish Pitchai , Anuraj Som

Quantum annealing has emerged as a powerful tool for solving combinatorial optimization problems efficiently, making use of the principles of quantum mechanics. Companies are increasingly investing in the market of quantum computers,…

Quantum Physics · Physics 2025-09-29 Lorenzo Mazzei , Giada Beccari , Mirko Laruina , Marco Cococcioni

We are interested in benchmarking both quantum annealing and classical algorithms for minimizing Quadratic Unconstrained Binary Optimization (QUBO) problems. Such problems are NP-hard in general, implying that the exact minima of randomly…

Quantum Physics · Physics 2023-11-28 Georg Hahn , Elijah Pelofske , Hristo N. Djidjev

We propose a novel method for reducing the number of variables in quadratic unconstrained binary optimization problems, using a quantum annealer (or any sampler) to fix the value of a large portion of the variables to values that have a…

Quantum Physics · Physics 2017-09-26 Hamed Karimi , Gili Rosenberg

In this work we investigate the capabilities of a hybrid quantum-classical procedure to explore the solution space using the D-Wave $2000Q^{TM}$ Quantum Annealer device. Here we study the ability of the Quantum hardware to solve the Number…

Quantum Physics · Physics 2020-03-10 Luca Asproni , Davide Caputo , Blanca Silva , Giovanni Fazzi , Marco Magagnini

Annealing machines specialized for combinatorial optimization problems have been developed, and some companies offer services to use those machines. Such specialized machines can only handle binary variables, and their input format is the…

Quantum Physics · Physics 2023-03-24 Yuki Furue , Makiko Konoshima , Hirotaka Tamura , Jun Ohkubo

Quantum annealing leverages the properties of interacting quantum spin systems to solve computational problems, typically optimisation problems. Current hardware now has capabilities that can be used to solve condensed matter physics…

Quantum Physics · Physics 2026-04-09 Viv Kendon , Nicholas Chancellor

Current quantum computing devices have different strengths and weaknesses depending on their architectures. This means that flexible approaches to circuit design are necessary. We address this task by introducing a novel space-efficient…