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Latent confounding has been a long-standing obstacle for causal reasoning from observational data. One popular approach is to model the data using acyclic directed mixed graphs (ADMGs), which describe ancestral relations between variables…

Machine Learning · Computer Science 2023-03-23 Matthew Ashman , Chao Ma , Agrin Hilmkil , Joel Jennings , Cheng Zhang

In causal discovery, non-Gaussianity has been used to characterize the complete configuration of a Linear Non-Gaussian Acyclic Model (LiNGAM), encompassing both the causal ordering of variables and their respective connection strengths.…

Machine Learning · Computer Science 2025-08-08 Tian-Le Yang , Kuang-Yao Lee , Kun Zhang , Joe Suzuki

We consider the problem of learning causal models from observational data generated by linear non-Gaussian acyclic causal models with latent variables. Without considering the effect of latent variables, one usually infers wrong causal…

Machine Learning · Computer Science 2019-08-13 Saber Salehkaleybar , AmirEmad Ghassami , Negar Kiyavash , Kun Zhang

Learning Granger causality for general point processes is a very challenging task. In this paper, we propose an effective method, learning Granger causality, for a special but significant type of point processes --- Hawkes process. We…

Machine Learning · Computer Science 2016-06-14 Hongteng Xu , Mehrdad Farajtabar , Hongyuan Zha

Commonly used methods to analyze incomplete longitudinal clinical trial data include complete case analysis (CC) and last observation carried forward (LOCF). However, such methods rest on strong assumptions, including missing completely at…

Statistics Theory · Mathematics 2007-06-13 Ivy Jansen , Caroline Beunckens , Geert Molenberghs , Geert Verbeke , Craig Mallinckrodt

We discuss the use of multivariate Granger causality in presence of redundant variables: the application of the standard analysis, in this case, leads to under-estimation of causalities. Using the un-normalized version of the causality…

Quantitative Methods · Quantitative Biology 2015-05-14 L. Angelini , M. de Tommaso , D. Marinazzo , L. Nitti , M. Pellicoro , S. Stramaglia

This paper addresses the problem of estimating causal directed acyclic graphs in linear non-Gaussian acyclic models with latent confounders (LvLiNGAM). Existing methods assume mutually independent latent confounders or cannot properly…

Machine Learning · Computer Science 2025-10-17 Ming Cai , Penggang Gao , Hisayuki Hara

Generative models using neural network have opened a door to large-scale studies for various application domains, especially for studies that suffer from lack of real samples to obtain statistically robust inference. Typically, these…

Computer Vision and Pattern Recognition · Computer Science 2018-12-12 Seong Jae Hwang , Zirui Tao , Won Hwa Kim , Vikas Singh

In many clinical trials treatments need to be repeatedly applied as diseases relapse frequently after remission over a long period of time (e.g., 35 weeks). Most research in statistics focuses on the overall trial design, such as sample…

Methodology · Statistics 2014-04-01 Yanxun Xu , Yuan Ji

Learning a causal directed acyclic graph from data is a challenging task that involves solving a combinatorial problem for which the solution is not always identifiable. A new line of work reformulates this problem as a continuous…

Machine Learning · Computer Science 2020-11-05 Philippe Brouillard , Sébastien Lachapelle , Alexandre Lacoste , Simon Lacoste-Julien , Alexandre Drouin

Longitudinal data is commonly utilised across various domains, such as health, biomedical, education and survey studies. This ubiquity has led to a rise in statistical, machine and deep learning-based methods for Longitudinal Data…

Machine Learning · Computer Science 2025-06-24 Sharon Torao Pingi , Md Abul Bashar , Richi Nayak

Temporal point process as the stochastic process on continuous domain of time is commonly used to model the asynchronous event sequence featuring with occurrence timestamps. Thanks to the strong expressivity of deep neural networks, they…

Machine Learning · Computer Science 2024-12-25 Haitao Lin , Cheng Tan , Lirong Wu , Zhangyang Gao , Zicheng Liu , Stan. Z. Li

Healthcare artificial intelligence systems often degrade in performance when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in data. This brittleness comes, in part, from…

Machine Learning · Computer Science 2026-03-30 Munib Mesinovic , Max Buhlan , Tingting Zhu

We introduce a novel framework for temporal causal discovery and inference that addresses two key challenges: complex nonlinear dependencies and spurious correlations. Our approach employs a multi-layer Transformer-based time-series…

Machine Learning · Computer Science 2025-08-25 Jihua Huang , Yi Yao , Ajay Divakaran

Concepts of Granger causality (GC) and Granger autonomy (GA) are central to assess the dynamics of coupled physiologic processes. While causality measures have been already proposed and applied in time and frequency domains, measures…

Signal Processing · Electrical Eng. & Systems 2023-07-20 Laura Sparacino , Yuri Antonacci , Chiara Barà , Angela Valenti , Alberto Porta , Luca Faes

Biomarker discovery from high-throughput transcriptomic data is crucial for advancing precision medicine. However, existing methods often neglect gene-gene regulatory relationships and lack stability across datasets, leading to conflation…

Quantitative Methods · Quantitative Biology 2025-11-18 Chaowang Lan , Jingxin Wu , Yulong Yuan , Chuxun Liu , Huangyi Kang , Caihua Liu

Graph topology inference of network processes with co-evolving and interacting time-series is crucial for network studies. Vector autoregressive models (VAR) are popular approaches for topology inference of directed graphs; however, in…

Machine Learning · Computer Science 2020-11-18 M. Ali Vosoughi , Axel Wismuller

Causal learning has long concerned itself with the accurate recovery of underlying causal mechanisms. Such causal modelling enables better explanations of out-of-distribution data. Prior works on causal learning assume that the high-level…

Causal discovery from time-series data has been a central task in machine learning. Recently, Granger causality inference is gaining momentum due to its good explainability and high compatibility with emerging deep neural networks. However,…

Machine Learning · Computer Science 2023-02-16 Yuxiao Cheng , Runzhao Yang , Tingxiong Xiao , Zongren Li , Jinli Suo , Kunlun He , Qionghai Dai

We analyze by means of Granger causality the effect of synergy and redundancy in the inference (from time series data) of the information flow between subsystems of a complex network. Whilst we show that fully conditioned Granger causality…

Quantitative Methods · Quantitative Biology 2015-06-19 Sebastiano Stramaglia , Jesus M. Cortes , Daniele Marinazzo
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