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A new pairwise hybrid machine-learning/molecular mechanics (ML/MM) potential is introduced that is conceived for application to large, heterogeneous condensed-phase systems. The PhysNet ML method describes monomers and short-range dimer…

Chemical Physics · Physics 2026-03-17 Kham Lek Chaton , Eric D. Boittier , Mike Devereux , Markus Meuwly

Computer simulation is an important tool for scientific progress, especially when lab experiments are either extremely costly and difficult or lack the required resolution. However, all of the simulation methods come with limitations. In…

Fluid Dynamics · Physics 2023-08-04 Edward R. Smith , Panagiotis E. Theodorakis

The force field describing the calculated interaction between atoms or molecules is the key to the accuracy of many molecular dynamics (MD) simulation results. Compared with traditional or semi-empirical force fields, machine learning force…

Computational Physics · Physics 2023-06-28 Yongle Li , Feng Xu , Long Hou , Luchao Sun , Haijun Su , Xi Li , Wei Ren

Machine learning force fields enable high-accuracy modeling of solid-state electrolytes (SSEs). This perspective evaluates dataset size, reference quality, and model architectures. We show that rigid SSE frameworks favor efficient learning,…

Materials Science · Physics 2026-03-10 Zihan Yan , Shengjie Tang , Yizhou Zhu

Recent years have seen a rise in interest in terms of using machine learning, particularly reinforcement learning (RL), for production scheduling problems of varying degrees of complexity. The general approach is to break down the…

Machine Learning · Computer Science 2023-02-16 Alexandru Rinciog , Anne Meyer

Machine-learning interatomic potentials (MLPs) are fast, data-driven surrogate models of atomistic systems' potential energy surfaces that can accelerate ab-initio molecular dynamics (MD) simulations by several orders of magnitude. The…

Materials Science · Physics 2024-09-23 Thomas Bischoff , Bastian Jäckl , Matthias Rupp

Classical molecular dynamics (MD) simulations are important tools in life and material sciences since they allow studying chemical and biological processes in detail. However, the inherent scalability problem of particle-particle…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-08-14 Michael Schaffner , Luca Benini

The rapid advancement of software development practices has introduced challenges in ensuring quality and efficiency across the software engineering (SE) lifecycle. As SE systems grow in complexity, traditional approaches often fail to…

Software Engineering · Computer Science 2025-08-04 Samah Kansab

Quantum mechanics based ab-initio molecular dynamics (MD) simulation schemes offer an accurate and direct means to monitor the time-evolution of materials. Nevertheless, the expensive and repetitive energy and force computations required in…

Materials Science · Physics 2014-10-14 Venkatesh Botu , Rampi Ramprasad

The demand for clean energy is ever increasing, with new nuclear technologies presenting a complementary solution to renewable energies. However, designing and operating these systems is exceptionally difficult, given the complexity of the…

Recent advances in probabilistic modelling have led to a large number of simulation-based inference algorithms which do not require numerical evaluation of likelihoods. However, a public benchmark with appropriate performance metrics for…

Machine Learning · Statistics 2021-04-12 Jan-Matthis Lueckmann , Jan Boelts , David S. Greenberg , Pedro J. Gonçalves , Jakob H. Macke

Machine learning force fields (MLFFs) have emerged as a sophisticated tool for cost-efficient atomistic simulations approaching DFT accuracy, with recent message passing MLFFs able to cover the entire periodic table. We present an invariant…

Machine Learning Force Fields (MLFFs) are a promising alternative to expensive ab initio quantum mechanical molecular simulations. Given the diversity of chemical spaces that are of interest and the cost of generating new data, it is…

Machine Learning · Computer Science 2025-05-30 Tobias Kreiman , Aditi S. Krishnapriyan

In the context of aircraft system performance assessment, deep learning technologies allow to quickly infer models from experimental measurements, with less detailed system knowledge than usually required by physics-based modeling. However,…

Machine Learning · Computer Science 2022-09-09 Houssem Ben Braiek , Thomas Reid , Foutse Khomh

The development of machine learning (ML) methods has made quantum chemistry (QC) calculations more accessible by reducing the compute cost incurred in conventional QC methods. This has since been translated into the overhead cost of…

Chemical Physics · Physics 2025-03-26 Vivin Vinod , Peter Zaspel

The promise of AI-driven scientific discovery hinges on whether AI agents can autonomously design and execute the computational workflows that underpin modern science. Molecular dynamics (MD) simulation presents a natural test bed to…

Artificial Intelligence · Computer Science 2026-05-12 Vinay Kumar , Satyendra Rajput , Mausam , N. M. Anoop Krishnan

The implementation of Molecular Dynamics (MD) on FPGAs has received substantial attention. Previous work, however, has consisted of either proof-of-concept implementations of components, usually the range-limited force; full systems, but…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-15 Chen Yang , Tong Geng , Tianqi Wang , Rushi Patel , Qingqing Xiong , Ahmed Sanaullah , Jiayi Sheng , Charles Lin , Vipin Sachdeva , Woody Sherman , Martin C. Herbordt

Neutronic calculations for reactors are a daunting task when using Monte Carlo (MC) methods. As high-performance computing has advanced, the simulation of a reactor is nowadays more readily done, but design and optimization with multiple…

Neural and Evolutionary Computing · Computer Science 2024-03-22 Deborah Schwarcz , Nadav Schneider , Gal Oren , Uri Steinitz

Machine-learned interatomic potentials (MLIPs) and force fields (i.e. interaction laws for atoms and molecules) are typically trained on limited data-sets that cover only a very small section of the full space of possible input structures.…

Numerical Analysis · Mathematics 2022-09-13 Christoph Ortner , Yangshuai Wang

The recent development of machine learning (ML) and Deep Learning (DL) increases the opportunities in all the sectors. ML is a significant tool that can be applied across many disciplines, but its direct application to civil engineering…

Machine Learning · Computer Science 2024-09-04 Shashank Reddy Vadyala , Sai Nethra Betgeri1 , John C. Matthews , Elizabeth Matthews