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Large language models have achieved strong performance on medical reasoning benchmarks, yet their deployment in clinical settings demands rigorous verification to ensure factual accuracy. While reward models offer a scalable approach for…

Artificial Intelligence · Computer Science 2026-01-29 Hang Zhang , Ruheng Wang , Yuelyu Ji , Mingu Kwak , Xizhi Wu , Chenyu Li , Li Zhang , Wenqi Shi , Yifan Peng , Yanshan Wang

In medical imaging, particularly in early disease detection and prognosis tasks, discerning the rationale behind an AI model's predictions is crucial for evaluating the reliability of its decisions. Conventional explanation methods face…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Yingying Fang , Zihao Jin , Xiaodan Xing , Simon Walsh , Guang Yang

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

While large language models hold promise for complex medical applications, their development is hindered by the scarcity of high-quality reasoning data. To address this issue, existing approaches typically distill chain-of-thought reasoning…

Machine Learning · Computer Science 2026-04-14 Haolin Li , Shuyang Jiang , Ruipeng Zhang , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Interpretable deep learning is a fundamental building block towards safer AI, especially when the deployment possibilities of deep learning-based computer-aided medical diagnostic systems are so eminent. However, without a computational…

Machine Learning · Computer Science 2018-06-27 Anirban Mukhopadhyay

Medical diagnosis is the process of making a prediction of the disease a patient is likely to have, given a set of symptoms and observations. This requires extensive expert knowledge, in particular when covering a large variety of diseases.…

Artificial Intelligence · Computer Science 2022-04-29 Niclas Heilig , Jan Kirchhoff , Florian Stumpe , Joan Plepi , Lucie Flek , Heiko Paulheim

Despite the growing use of Electronic Health Records (EHR) for AI-assisted diagnosis prediction, most data-driven models struggle to incorporate clinically meaningful medical knowledge. They often rely on limited ontologies, lacking…

Machine Learning · Computer Science 2025-04-17 Pengfei Hu , Chang Lu , Fei Wang , Yue Ning

The adoption of machine learning in high-stakes applications such as healthcare and law has lagged in part because predictions are not accompanied by explanations comprehensible to the domain user, who often holds the ultimate…

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

Diagnosis-oriented dialogue system queries the patient's health condition and makes predictions about possible diseases through continuous interaction with the patient. A few studies use reinforcement learning (RL) to learn the optimal…

Computation and Language · Computer Science 2022-12-27 Wei Chen , Cheng Zhong , Jiajie Peng , Zhongyu Wei

Though deep learning has shown successful performance in classifying the label and severity stage of certain diseases, most of them give few explanations on how to make predictions. Inspired by Koch's Postulates, the foundation in…

Image and Video Processing · Electrical Eng. & Systems 2022-05-02 Yuhao Niu , Lin Gu , Yitian Zhao , Feng Lu

The integration of Large Language Models (LLMs) into healthcare is constrained by knowledge limitations, hallucinations, and a disconnect from Evidence-Based Medicine (EBM). While Retrieval-Augmented Generation (RAG) offers a solution,…

Computation and Language · Computer Science 2026-02-03 Qiaoyu Zheng , Yuze Sun , Chaoyi Wu , Weike Zhao , Pengcheng Qiu , Yongguo Yu , Kun Sun , Jian Zhang , Yanfeng Wang , Ya Zhang , Weidi Xie

As the field of healthcare increasingly adopts artificial intelligence, it becomes important to understand which types of explanations increase transparency and empower users to develop confidence and trust in the predictions made by…

Artificial Intelligence · Computer Science 2025-05-16 Felix Liedeker , Olivia Sanchez-Graillet , Moana Seidler , Christian Brandt , Jörg Wellmer , Philipp Cimiano

Effectively representing medical concepts and patients is important for healthcare analytical applications. Representing medical concepts for healthcare analytical tasks requires incorporating medical domain knowledge and prior information…

Machine Learning · Computer Science 2023-05-02 Shaodong Wang , Qing Li , Wenli Zhang

Chronic diseases are long-term, manageable, yet typically incurable conditions, highlighting the need for effective preventive strategies. Machine learning has been widely used to assess individual risk for chronic diseases. However, many…

Machine Learning · Computer Science 2025-06-24 Minh Le , Khoi Ton

Artificial intelligence (AI) continues to transform data analysis in many domains. Progress in each domain is driven by a growing body of annotated data, increased computational resources, and technological innovations. In medicine, the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Ahmad Chaddad , Qizong lu , Jiali Li , Yousef Katib , Reem Kateb , Camel Tanougast , Ahmed Bouridane , Ahmed Abdulkadir

An integrated approach is proposed across visual and textual data to both determine and justify a medical diagnosis by a neural network. As deep learning techniques improve, interest grows to apply them in medical applications. To enable a…

Machine Learning · Computer Science 2019-07-15 Graham Spinks , Marie-Francine Moens

With the advancement of internet communication and telemedicine, people are increasingly turning to the web for various healthcare activities. With an ever-increasing number of diseases and symptoms, diagnosing patients becomes challenging.…

Artificial Intelligence · Computer Science 2024-05-21 Mohit Tomar , Abhisek Tiwari , Sriparna Saha

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman