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Randomized experiments ensure robust causal inference that are critical to effective learning analytics research and practice. However, traditional randomized experiments, like A/B tests, are limiting in large scale digital learning…

Applications · Statistics 2019-02-04 Timothy NeCamp , Josh Gardner , Christopher Brooks

Single-cell RNA-sequencing (scRNA-seq) has become a routinely used technique to quantify the gene expression profile of thousands of single cells simultaneously. Analysis of scRNA-seq data plays an important role in the study of cell states…

Genomics · Quantitative Biology 2022-10-13 Matthew Brendel , Chang Su , Zilong Bai , Hao Zhang , Olivier Elemento , Fei Wang

Spatial variable genes (SVGs) reveal critical information about tissue architecture, cellular interactions, and disease microenvironments. As spatial transcriptomics (ST) technologies proliferate, accurately identifying SVGs across diverse…

Applications · Statistics 2025-10-21 Jiawen Chen , Jinwei Zhang , Dongshen Peng , Yutong Song , Aitong Ruan , Yun Li , Didong Li

Spatial transcriptomics enables gene expression profiling with spatial context, offering unprecedented insights into the tissue microenvironment. However, most computational models treat genes as isolated numerical features, ignoring the…

Machine Learning · Computer Science 2025-11-17 Jiangkai Long , Yanran Zhu , Chang Tang , Kun Sun , Yuanyuan Liu , Xuesong Yan

Subsampled Randomized Hadamard Transform (SRHT), a popular random projection method that can efficiently project a $d$-dimensional data into $r$-dimensional space ($r \ll d$) in $O(dlog(d))$ time, has been widely used to address the…

Machine Learning · Computer Science 2020-10-07 Zijian Lei , Liang Lan

Remote sensing spatiotemporal fusion (STF) addresses the fundamental trade-off between temporal and spatial resolution by combining high temporal-low spatial and high spatial-low temporal imagery. This paper presents the first comprehensive…

Computer Vision and Pattern Recognition · Computer Science 2025-07-14 Enzhe Sun , Yongchuan Cui , Peng Liu , Jining Yan

With the advent of Deep Learning (DL), Super-Resolution (SR) has also become a thriving research area. However, despite promising results, the field still faces challenges that require further research e.g., allowing flexible upsampling,…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Brian Moser , Federico Raue , Stanislav Frolov , Jörn Hees , Sebastian Palacio , Andreas Dengel

Spatial Transcriptomics (ST) provides spatially resolved gene expression profiles within intact tissue architecture, enabling molecular analysis in histological context. However, the high cost, limited throughput, and restricted data…

Machine Learning · Computer Science 2026-03-31 Yaoyu Fang , Jiahe Qian , Xinkun Wang , Lee A. Cooper , Bo Zhou

Spatial transcriptomics (ST) provides high-resolution pathological images and whole-transcriptomic expression profiles at individual spots across whole-slide scales. This setting makes it an ideal data source to develop multimodal…

Computer Vision and Pattern Recognition · Computer Science 2024-11-27 Yuxiang Lin , Ling Luo , Ying Chen , Xushi Zhang , Zihui Wang , Wenxian Yang , Mengsha Tong , Rongshan Yu

The rapid development of spatial transcriptomics (ST) technologies is revolutionizing our understanding of the spatial organization of biological tissues. Current ST methods, categorized into next-generation sequencing-based (seq-based) and…

Machine Learning · Computer Science 2024-07-19 Xiaoyu Li , Fangfang Zhu , Wenwen Min

Deep unfolding networks have recently gained popularity in the context of solving imaging inverse problems. However, the computational and memory complexity of data-consistency layers within traditional deep unfolding networks scales with…

Image and Video Processing · Electrical Eng. & Systems 2021-06-04 Jiaming Liu , Yu Sun , Weijie Gan , Xiaojian Xu , Brendt Wohlberg , Ulugbek S. Kamilov

Medical data often exhibits distribution shifts, which cause test-time performance degradation for deep learning models trained using standard supervised learning pipelines. This challenge is addressed in the field of Domain Generalization…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Aleksandr Matsun , Numan Saeed , Fadillah Adamsyah Maani , Mohammad Yaqub

In order to understand the complexities of cellular biology, researchers are interested in two important metrics: the genetic expression information of cells and their spatial coordinates within a tissue sample. However, state-of-the art…

Machine Learning · Computer Science 2023-11-02 J. Ding , S. N. Zaman , P. Y. Chen , D. Wang

Hyperspectral image (HSI) classification has become a hot topic in the field of remote sensing. In general, the complex characteristics of hyperspectral data make the accurate classification of such data challenging for traditional machine…

Image and Video Processing · Electrical Eng. & Systems 2019-10-30 Shutao Li , Weiwei Song , Leyuan Fang , Yushi Chen , Pedram Ghamisi , Jón Atli Benediktsson

Relative Geologic Time (RGT) estimation from seismic data is a cornerstone of subsurface structural modeling, depositional evolution analysis, and reservoir characterization, supporting horizon correlation and depositional system…

Geophysics · Physics 2026-05-21 Yimin Dou , Xinming Wu , Hui Gao , Zhengfa Bi

Deep learning has shown great promise for CT image reconstruction, in particular to enable low dose imaging and integrated diagnostics. These merits, however, stand at great odds with the low availability of diverse image data which are…

Computer Vision and Pattern Recognition · Computer Science 2021-03-23 Arjun Krishna , Kedar Bartake , Chuang Niu , Ge Wang , Youfang Lai , Xun Jia , Klaus Mueller

Single-image super-resolution (SISR) is an important task in image processing, which aims to enhance the resolution of imaging systems. Recently, SISR has made a huge leap and has achieved promising results with the help of deep learning…

Image and Video Processing · Electrical Eng. & Systems 2024-04-15 Juncheng Li , Zehua Pei , Wenjie Li , Guangwei Gao , Longguang Wang , Yingqian Wang , Tieyong Zeng

Single-cell RNA-sequencing technologies may provide valuable insights to the understanding of the composition of different cell types and their functions within a tissue. Recent technologies such as spatial transcriptomics, enable the…

Applications · Statistics 2023-05-16 Arhit Chakrabarti , Yang Ni , Bani K. Mallick

MRI-guided radiation therapy (MRgRT) offers a precise and adaptive approach to treatment planning. Deep learning applications which augment the capabilities of MRgRT are systematically reviewed. MRI-guided radiation therapy offers a…

Medical Physics · Physics 2023-03-31 Zach Eidex , Yifu Ding , Jing Wang , Elham Abouei , Richard L. J. Qiu , Tian Liu , Tonghe Wang , Xiaofeng Yang

Image Super-Resolution (SR) is an important class of image processing techniques to enhance the resolution of images and videos in computer vision. Recent years have witnessed remarkable progress of image super-resolution using deep…

Computer Vision and Pattern Recognition · Computer Science 2020-02-11 Zhihao Wang , Jian Chen , Steven C. H. Hoi