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Interpreting time series models is uniquely challenging because it requires identifying both the location of time series signals that drive model predictions and their matching to an interpretable temporal pattern. While explainers from…

Machine Learning · Computer Science 2023-10-26 Owen Queen , Thomas Hartvigsen , Teddy Koker , Huan He , Theodoros Tsiligkaridis , Marinka Zitnik

The classification of time-series data is pivotal for streaming data and comes with many challenges. Although the amount of publicly available datasets increases rapidly, deep neural models are only exploited in a few areas. Traditional…

Machine Learning · Computer Science 2021-09-27 Dominique Mercier , Andreas Dengel , Sheraz Ahmed

Clinical data for ambulatory care, which accounts for 90% of the nations healthcare spending, is characterized by relatively small sample sizes of longitudinal data, unequal spacing between visits for each patient, with unequal numbers of…

Machine Learning · Computer Science 2018-12-03 Beau Norgeot , Dmytro Lituiev , Benjamin S. Glicksberg , Atul J. Butte

Hierarchical forecasting is a key problem in many practical multivariate forecasting applications - the goal is to simultaneously predict a large number of correlated time series that are arranged in a pre-specified aggregation hierarchy.…

Machine Learning · Computer Science 2021-10-13 Biswajit Paria , Rajat Sen , Amr Ahmed , Abhimanyu Das

While the volume of electronic health records (EHR) data continues to grow, it remains rare for hospital systems to capture dense physiological data streams, even in the data-rich intensive care unit setting. Instead, typical EHR records…

Machine Learning · Computer Science 2018-12-04 Satya Narayan Shukla , Benjamin M. Marlin

Accurate and interpretable mortality risk prediction in intensive care units (ICUs) remains a critical challenge due to the irregular temporal structure of electronic health records (EHRs), the complexity of longitudinal disease…

Machine Learning · Computer Science 2026-03-10 Zahra Jafari , Azadeh Zamanifar , Amirfarhad Farhadi

Clinical notes in electronic health records contain highly heterogeneous writing styles, including non-standard terminology or abbreviations. Using these notes in predictive modeling has traditionally required preprocessing (e.g. taking…

Machine Learning · Computer Science 2019-11-18 Jonas Kemp , Alvin Rajkomar , Andrew M. Dai

Modern applications have made ubiquitous high-dimensional data, especially time-dependent data, with more and more complicated structures, and it also has become more frequent to encounter the scenario of hierarchical relationships among…

Methodology · Statistics 2026-04-06 Lan Li , Shibo Yu , Yingzhou Wang , Guodong Li

Health conditions among patients in intensive care units (ICUs) are monitored via electronic health records (EHRs), composed of numerical time series and lengthy clinical note sequences, both taken at irregular time intervals. Dealing with…

Machine Learning · Computer Science 2023-06-07 Xinlu Zhang , Shiyang Li , Zhiyu Chen , Xifeng Yan , Linda Petzold

Machine learning has been widely used in healthcare applications to approximate complex models, for clinical diagnosis, prognosis, and treatment. As deep learning has the outstanding ability to extract information from time series, its true…

Machine Learning · Computer Science 2022-11-14 Ke Liao , Wei Wang , Armagan Elibol , Lingzhong Meng , Xu Zhao , Nak Young Chong

Effectively medication recommendation with complex multimorbidity conditions is a critical task in healthcare. Most existing works predicted medications based on longitudinal records, which assumed the information transmitted patterns of…

Machine Learning · Computer Science 2023-09-13 Sicen Liu , Xiaolong Wang , JIngcheng Du , Yongshuai Hou , Xianbing Zhao , Hui Xu , Hui Wang , Yang Xiang , Buzhou Tang

Explainability in time series models is crucial for fostering trust, facilitating debugging, and ensuring interpretability in real-world applications. In this work, we introduce Implet, a novel post-hoc explainer that generates accurate and…

Machine Learning · Computer Science 2025-05-14 Fanyu Meng , Ziwen Kan , Shahbaz Rezaei , Zhaodan Kong , Xin Chen , Xin Liu

This paper describes methods for comparative evaluation of the interpretability of models of high dimensional time series data inferred by unsupervised machine learning algorithms. The time series data used in this investigation were logs…

Artificial Intelligence · Computer Science 2020-05-05 Nicholas Hoernle , Kobi Gal , Barbara Grosz , Leilah Lyons , Ada Ren , Andee Rubin

Deep learning has made significant advances in creating efficient representations of time series data by automatically identifying complex patterns. However, these approaches lack interpretability, as the time series is transformed into a…

Machine Learning · Computer Science 2023-10-26 Etienne Le Naour , Ghislain Agoua , Nicolas Baskiotis , Vincent Guigue

Deep learning methods are powerful tools in classifying multivariate time series data. Despite their high performance, these methods are hard to interpret, which diminishes their applications in high-risk domains such as healthcare. In this…

Machine Learning · Computer Science 2026-05-11 Bhavesh Kalisetti , Vincent Wang , Gaurav R. Ghosal , Maryam Bijanzadeh , Reza Abbasi-Asl

We explore the hyperparameters and introduce a methodological framework to convert disease patterns from time series data of blood test results into correlation graphs for causal hypothesis exploration. The networks represent hypotheses…

Other Quantitative Biology · Quantitative Biology 2025-12-29 David Patrick Duys Montealegre , Alexander Fulton , Mahta Haghighat Ghahfarokhi , Abicumaran Uthamacumaran , Hector Zenil

Context: Utilization of operating theaters is a major cost driver in hospitals. Optimizing this variable through optimized surgery schedules may significantly lower cost and simultaneously improve medical outcomes. Previous studies proposed…

Applications · Statistics 2025-09-05 Harald Störrle , Anastasia Hort

Multivariate time series have many applications, from healthcare and meteorology to life science. Although deep learning models have shown excellent predictive performance for time series, they have been criticised for being "black-boxes"…

Machine Learning · Computer Science 2024-05-06 Qiqi Su , Christos Kloukinas , Artur d'Avila Garcez

Problem definition: Access to accurate predictions of patients' outcomes can enhance medical staff's decision-making, which ultimately benefits all stakeholders in the hospitals. A large hospital network in the US has been collaborating…

Postoperative stroke remains a critical complication in elderly surgical intensive care unit (SICU) patients, contributing to prolonged hospitalization, elevated healthcare costs, and increased mortality. Accurate early risk stratification…

Quantitative Methods · Quantitative Biology 2025-06-05 Tinghuan Li , Shuheng Chen , Junyi Fan , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar