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Extraction of latent sources of complex stimuli is critical for making sense of the world. While the brain solves this blind source separation (BSS) problem continuously, its algorithms remain unknown. Previous work on…

Signal Processing · Electrical Eng. & Systems 2022-11-28 Bariscan Bozkurt , Cengiz Pehlevan , Alper T. Erdogan

An important problem in neuroscience is to understand how brains extract relevant signals from mixtures of unknown sources, i.e., perform blind source separation. To model how the brain performs this task, we seek a biologically plausible…

Signal Processing · Electrical Eng. & Systems 2022-03-08 David Lipshutz , Cengiz Pehlevan , Dmitri B. Chklovskii

The backpropagation algorithm has experienced remarkable success in training large-scale artificial neural networks; however, its biological plausibility has been strongly criticized, and it remains an open question whether the brain…

Neural and Evolutionary Computing · Computer Science 2026-03-27 Bariscan Bozkurt , Cengiz Pehlevan , Alper T Erdogan

Blind source separation, i.e. extraction of independent sources from a mixture, is an important problem for both artificial and natural signal processing. Here, we address a special case of this problem when sources (but not the mixing…

Neurons and Cognition · Quantitative Biology 2017-10-20 Cengiz Pehlevan , Sreyas Mohan , Dmitri B. Chklovskii

Humans excel at continually acquiring, consolidating, and retaining information from an ever-changing environment, whereas artificial neural networks (ANNs) exhibit catastrophic forgetting. There are considerable differences in the…

Neural and Evolutionary Computing · Computer Science 2023-04-17 Fahad Sarfraz , Elahe Arani , Bahram Zonooz

An important problem encountered by both natural and engineered signal processing systems is blind source separation. In many instances of the problem, the sources are bounded by their nature and known to be so, even though the particular…

Signal Processing · Electrical Eng. & Systems 2020-04-14 Alper T. Erdogan , Cengiz Pehlevan

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

Why do biological and artificial neurons sometimes modularise, each encoding a single meaningful variable, and sometimes entangle their representation of many variables? In this work, we develop a theory of when biologically inspired…

Neurons and Cognition · Quantitative Biology 2025-08-05 Will Dorrell , Kyle Hsu , Luke Hollingsworth , Jin Hwa Lee , Jiajun Wu , Chelsea Finn , Peter E Latham , Tim EJ Behrens , James CR Whittington

Characterizing the capacity region for a network can be extremely difficult. Even with independent sources, determining the capacity region can be as hard as the open problem of characterizing all information inequalities. The majority of…

Information Theory · Computer Science 2013-09-09 Satyajit Thakor , Terence Chan , Alex Grant

Explicit characterization of the capacity region of communication networks is a long standing problem. While it is known that network coding can outperform routing and replication, the set of feasible rates is not known in general.…

Information Theory · Computer Science 2016-04-13 Satyajit Thakor , Alex Grant , Terence Chan

Biological and artificial learning agents face numerous choices about how to learn, ranging from hyperparameter selection to aspects of task distributions like curricula. Understanding how to make these meta-learning choices could offer…

Neural and Evolutionary Computing · Computer Science 2024-07-16 Rodrigo Carrasco-Davis , Javier Masís , Andrew M. Saxe

Neural-network models of high-level brain functions such as memory recall and reasoning often rely on the presence of stochasticity. The majority of these models assumes that each neuron in the functional network is equipped with its own…

Neurons and Cognition · Quantitative Biology 2022-05-17 Jakob Jordan , Mihai A. Petrovici , Oliver Breitwieser , Johannes Schemmel , Karlheinz Meier , Markus Diesmann , Tom Tetzlaff

In recent years many methods have been developed to understand the internal workings of neural networks, often by describing the function of individual neurons in the model. However, these methods typically only focus on explaining the very…

Machine Learning · Computer Science 2024-05-14 Tuomas Oikarinen , Tsui-Wei Weng

Artificial and natural neural network models are a new toolkit which could be potentially have been used for clarifying of complex brain functions. To attend this goal, such models need to be neurobiologically realistic. However, although…

Neurons and Cognition · Quantitative Biology 2022-07-08 Arsenii Onuchin

The independent evolution of intelligence in biological and artificial systems offers a unique opportunity to identify its fundamental computational principles. Here we show that large language models spontaneously develop synergistic cores…

Computational modeling plays an increasingly important role in neuroscience, highlighting the philosophical question of how computational models explain. In the context of neural network models for neuroscience, concerns have been raised…

Neurons and Cognition · Quantitative Biology 2021-04-15 Rosa Cao , Daniel Yamins

Information flow provides a natural measure for the causal interaction between dynamical events. This study extends our previous rigorous formalism of componentwise information flow to the bulk information flow between two complex…

Neurons and Cognition · Quantitative Biology 2021-12-30 X. San Liang

Characterising the capacity region for a network can be extremely difficult. Even with independent sources, determining the capacity region can be as hard as the open problem of characterising all information inequalities. The majority of…

Information Theory · Computer Science 2016-07-12 Satyajit Thakor , Terence Chan , Alex Grant

The response time of physical computational elements is finite, and neurons are no exception. In hierarchical models of cortical networks each layer thus introduces a response lag. This inherent property of physical dynamical systems…

Neurons and Cognition · Quantitative Biology 2021-10-28 Paul Haider , Benjamin Ellenberger , Laura Kriener , Jakob Jordan , Walter Senn , Mihai A. Petrovici

Biological information processing manifests a huge variety in its complexity and capability among different organisms, which presumably stems from the evolutionary optimization under limited computational resources. Starting from the…

Biological Physics · Physics 2025-10-21 Takehiro Tottori , Tetsuya J. Kobayashi
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