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Retrosynthesis, which aims to identify viable synthetic pathways for target molecules by decomposing them into simpler precursors, is often treated as a search problem. However, its complexity arises from multi-branched tree-structured…

Artificial Intelligence · Computer Science 2025-11-25 Chengyang Tian , Yuhang Chang , Yangpeng Zhang , Yang Liu

In genome-scale constraint-based metabolic models, gene deletion strategies are essential for achieving growth-coupled production, where cell growth and target metabolite synthesis occur simultaneously. Despite the inherently networked…

Quantitative Methods · Quantitative Biology 2026-04-10 Ziwei Yang , Takeyuki Tamura

In deep neural networks, better results can often be obtained by increasing the complexity of previously developed basic models. However, it is unclear whether there is a way to boost performance by decreasing the complexity of such models.…

Machine Learning · Computer Science 2022-06-07 Junran Wu , Shangzhe Li , Jianhao Li , Yicheng Pan , Ke Xu

Random forests are an ensemble method relevant for many problems, such as regression or classification. They are popular due to their good predictive performance (compared to, e.g., decision trees) requiring only minimal tuning of…

Methodology · Statistics 2022-10-20 Nikolaus Umlauf , Nadja Klein

We introduce a data-driven framework to automatically identify interpretable and physically meaningful hyperelastic constitutive models from sparse data. Leveraging symbolic regression, an algorithm based on genetic programming, our…

Symbolic Computation · Computer Science 2025-01-14 Jixin Hou , Xianyan Chen , Taotao Wu , Ellen Kuhl , Xianqiao Wang

Deep learning in computational biochemistry has traditionally focused on molecular graphs neural representations; however, recent advances in language models highlight how much scientific knowledge is encoded in text. To bridge these two…

Machine Learning · Computer Science 2023-07-26 Romain Lacombe , Andrew Gaut , Jeff He , David Lüdeke , Kateryna Pistunova

Machine Learning (ML) has the potential to accelerate discovery of new materials and shed light on useful properties of existing materials. A key difficulty when applying ML in Materials Science is that experimental datasets of material…

Recursive neural networks (RvNN) have been shown useful for learning sentence representations and helped achieve competitive performance on several natural language inference tasks. However, recent RvNN-based models fail to learn simple…

Computation and Language · Computer Science 2021-04-13 Atul Sahay , Ayush Maheshwari , Ritesh Kumar , Ganesh Ramakrishnan , Manjesh Kumar Hanawal , Kavi Arya

Neural Networks and Decision Trees: two popular techniques for supervised learning that are seemingly disconnected in their formulation and optimization method, have recently been combined in a single construct. The connection pivots on…

Machine Learning · Statistics 2020-02-27 Giuseppe Nuti , Lluís Antoni Jiménez Rugama , Kaspar Thommen

Based on decision trees, many fields have arguably made tremendous progress in recent years. In simple words, decision trees use the strategy of "divide-and-conquer" to divide the complex problem on the dependency between input features and…

Machine Learning · Computer Science 2021-01-22 Jinxiong Zhang

While speculative decoding has recently appeared as a promising direction for accelerating the inference of large language models (LLMs), the speedup and scalability are strongly bounded by the token acceptance rate. Prevalent methods…

Machine Learning · Computer Science 2024-10-16 Yunfan Xiong , Ruoyu Zhang , Yanzeng Li , Tianhao Wu , Lei Zou

Constructing appropriate representations of molecules lies at the core of numerous tasks such as material science, chemistry and drug designs. Recent researches abstract molecules as attributed graphs and employ graph neural networks (GNN)…

Machine Learning · Computer Science 2021-07-29 Jianwen Chen , Shuangjia Zheng , Ying Song , Jiahua Rao , Yuedong Yang

In recent years, work has gone into developing deep interpretable methods for image classification that clearly attributes a model's output to specific features of the data. One such of these methods is the Prototypical Part Network…

Machine Learning · Computer Science 2024-06-05 Aaron J. Li , Robin Netzorg , Zhihan Cheng , Zhuoqin Zhang , Bin Yu

Dependency trees help relation extraction models capture long-range relations between words. However, existing dependency-based models either neglect crucial information (e.g., negation) by pruning the dependency trees too aggressively, or…

Computation and Language · Computer Science 2018-09-28 Yuhao Zhang , Peng Qi , Christopher D. Manning

In this paper, we investigate the problem of reasoning over natural language statements. Prior neural based approaches do not explicitly consider the inter-dependency among answers and their proofs. In this paper, we propose PRobr, a novel…

Computation and Language · Computer Science 2021-07-07 Changzhi Sun , Xinbo Zhang , Jiangjie Chen , Chun Gan , Yuanbin Wu , Jiaze Chen , Hao Zhou , Lei Li

The field of machine learning is subject to an increasing interest in models that are not only accurate but also interpretable and robust, thus allowing their end users to understand and trust AI systems. This paper presents a novel method…

Machine Learning · Computer Science 2026-04-24 Valentin Lemaire , Gaël Aglin , Siegfried Nijssen

Representing a graph as a vector is a challenging task; ideally, the representation should be easily computable and conducive to efficient comparisons among graphs, tailored to the particular data and analytical task at hand. Unfortunately,…

Social and Information Networks · Computer Science 2018-11-16 Anton Tsitsulin , Davide Mottin , Panagiotis Karras , Alex Bronstein , Emmanuel Müller

Retrosynthetic planning, which aims to find a reaction pathway to synthesize a target molecule, plays an important role in chemistry and drug discovery. This task is usually modeled as a search problem. Recently, data-driven methods have…

Artificial Intelligence · Computer Science 2022-06-24 Shufang Xie , Rui Yan , Peng Han , Yingce Xia , Lijun Wu , Chenjuan Guo , Bin Yang , Tao Qin

The prediction of physicochemical properties from molecular structures is a crucial task for artificial intelligence aided molecular design. A growing number of Graph Neural Networks (GNNs) have been proposed to address this challenge.…

Machine Learning · Computer Science 2020-11-17 Shuo Zhang , Yang Liu , Lei Xie

This paper describes techniques for growing classification and regression trees designed to induce visually interpretable trees. This is achieved by penalizing splits that extend the subset of features used in a particular branch of the…

Methodology · Statistics 2013-10-22 Alex Goldstein , Andreas Buja