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A theoretical framework describing the set of interactions between neurons in the brain, or functional connectivity, should include dynamical functions representing the propagation of signal from one neuron to another. Green's functions and…

Neurons and Cognition · Quantitative Biology 2021-03-24 Francesco Randi , Andrew M. Leifer

Current functional Magnetic Resonance Imaging technology is able to resolve billions of individual functional connections characterizing the human connectome. Classical statistical inferential procedures attempting to make valid inferences…

Quantitative Methods · Quantitative Biology 2023-01-11 Alfonso Nieto-Castanon

Graphical models have been used extensively for modeling brain connectivity networks. However, unmeasured confounders and correlations among measurements are often overlooked during model fitting, which may lead to spurious scientific…

Methodology · Statistics 2020-12-10 Yanxin Jin , Yang Ning , Kean Ming Tan

Imaging neuroscience links brain activation maps to behavior and cognition via correlational studies. Due to the nature of the individual experiments, based on eliciting neural response from a small number of stimuli, this link is…

Machine Learning · Statistics 2013-11-21 Yannick Schwartz , Bertrand Thirion , Gaël Varoquaux

Deep graph-theoretic ideas in the context with the graph of the World Wide Web led to the definition of Google's PageRank and the subsequent rise of the most-popular search engine to date. Brain graphs, or connectomes, are being widely…

Neurons and Cognition · Quantitative Biology 2016-02-17 Balazs Szalkai , Balint Varga , Vince Grolmusz

How an individual's unique brain connectivity determines that individual's cognition, behavior, and risk for pathology is a fundamental question in basic and clinical neuroscience. In seeking answers, many have turned to machine learning,…

Neurons and Cognition · Quantitative Biology 2023-12-08 Maxwell A. Bertolero , Dustin Moraczewski , Adam Thomas , Danielle S. Bassett

Functional brain imaging allows measuring dynamic functionality in all brain regions. It is broadly used in clinical cognitive neuroscience as, well as in research. It will allow the observation of neural activities in the brain…

Medical Physics · Physics 2016-04-01 Saman Sarraf , Jian Sun

Functional connectivity is a fundamental property of neural networks that quantifies the segregation and integration of information between cortical areas. Due to mathematical complexity, a theory that could explain how the parameters of…

Neurons and Cognition · Quantitative Biology 2016-05-27 Diego Fasoli , Anna Cattani , Stefano Panzeri

Studies in recent years have demonstrated that neural organization and structure impact an individual's ability to perform a given task. Specifically, individuals with greater neural efficiency have been shown to outperform those with less…

The human connectome has been widely studied over the past decade. A principal finding is that it can be decomposed into communities of densely interconnected brain regions. This result, however, may be limited methodologically. Past…

Large bundles of myelinated axons, called white matter, anatomically connect disparate brain regions together and compose the structural core of the human connectome. We recently proposed a method of measuring the local integrity along the…

Applications · Statistics 2018-09-18 Yo Joong Choe , Sivaraman Balakrishnan , Aarti Singh , Jean M. Vettel , Timothy Verstynen

A novel non-parametric estimator of the correlation between grouped measurements of a quantity is proposed in the presence of noise. This work is primarily motivated by functional brain network construction from fMRI data, where brain…

Methodology · Statistics 2023-02-16 Hanâ Lbath , Alexander Petersen , Wendy Meiring , Sophie Achard

The human connectome at the level of fiber tracts between brain regions has been shown to differ in patients with brain disorders compared to healthy control groups. Nonetheless, there is a potentially large number of different network…

Neurons and Cognition · Quantitative Biology 2013-10-16 Marcus Kaiser

Structural covariance analysis is a widely used structural MRI analysis method which characterises the co-relations of morphology between brain regions over a group of subjects. To our knowledge, little has been investigated in terms of the…

Neurons and Cognition · Quantitative Biology 2020-06-01 Jona Carmon , Jil Heege , Joe H Necus , Thomas W Owen , Gordon Pipa , Marcus Kaiser , Peter N Taylor , Yujiang Wang

Dynamic functional connectivity is an effective measure for the brain's responses to continuous stimuli. We propose an inferential method to detect the dynamic changes of brain networks based on time-varying graphical models. Whereas most…

Applications · Statistics 2020-06-23 Dingjue Ji , Junwei Lu , Yiliang Zhang , Hongyu Zhao , Siyuan Gao

Estimating the covariance structure of multivariate time series is a fundamental problem with a wide-range of real-world applications -- from financial modeling to fMRI analysis. Despite significant recent advances, current state-of-the-art…

Machine Learning · Computer Science 2021-02-12 Hrayr Harutyunyan , Daniel Moyer , Hrant Khachatrian , Greg Ver Steeg , Aram Galstyan

What is the relationship between brain and behavior? The answer to this question necessitates characterizing the mapping between structure and function. The aim of this paper is to discuss broad issues surrounding the link between structure…

Neurons and Cognition · Quantitative Biology 2015-06-19 Luiz Pessoa

Whole-brain neural connectivity data are now available from viral tracing experiments, which reveal the connections between a source injection site and elsewhere in the brain. These hold the promise of revealing spatial patterns of…

Neurons and Cognition · Quantitative Biology 2016-10-27 Kameron Decker Harris , Stefan Mihalas , Eric Shea-Brown

We analyze the complex networks associated with brain electrical activity. Multichannel EEG measurements are first processed to obtain 3D voxel activations using the tomographic algorithm LORETA. Then, the correlation of the current…

Biological Physics · Physics 2007-05-23 G. Ruffini , C. Ray , J. Marco , L. Fuentemilla , C. Grau

The human brain is ultimately responsible for all thoughts and movements that the body produces. This allows humans to successfully interact with their environment. If the brain is not functioning properly many abilities of human can be…

Neurons and Cognition · Quantitative Biology 2018-07-09 Esmaeil Seraj