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Design-based inference, also known as randomization-based or finite-population inference, provides a principled framework for trustworthy statistical inference by attributing randomness solely to the design mechanism (e.g., treatment…

Methodology · Statistics 2026-04-17 Siyu Heng , Yanxin Shen , Zijian Guo

Diagnostic accuracy studies assess sensitivity and specificity of a new index test in relation to an established comparator or the reference standard. The development and selection of the index test is usually assumed to be conducted prior…

Methodology · Statistics 2022-08-30 Max Westphal , Antonia Zapf

In some multivariate problems with missing data, pairs of variables exist that are never observed together. For example, some modern biological tools can produce data of this form. As a result of this structure, the covariance matrix is…

Methodology · Statistics 2013-08-13 Max Grazier G'Sell , Shai S. Shen-Orr , Robert Tibshirani

Neuroimaging meta-analysis is an important tool for finding consistent effects over studies that each usually have 20 or fewer subjects. Interest in meta-analysis in brain mapping is also driven by a recent focus on so-called "reverse…

Applications · Statistics 2014-12-05 Jian Kang , Thomas E. Nichols , Tor D. Wager , Timothy D. Johnson

Prediction-powered inference (PPI) is a recent framework for valid statistical inference with partially labeled data, combining model-based predictions on a large unlabeled set with bias correction from a smaller labeled subset. Building on…

Machine Learning · Statistics 2026-03-25 Jyotishka Datta , Nicholas G. Polson

A common approach for handling missing values in data analysis pipelines is multiple imputation via software packages such as MICE (Van Buuren and Groothuis-Oudshoorn, 2011) and Amelia (Honaker et al., 2011). These packages typically assume…

Methodology · Statistics 2025-07-23 Trung Phung , Kyle Reese , Ilya Shpitser , Rohit Bhattacharya

We develop a general approach to valid inference after model selection. At the core of our framework is a result that characterizes the distribution of a post-selection estimator conditioned on the selection event. We specialize the…

Statistics Theory · Mathematics 2016-05-04 Jason D. Lee , Dennis L. Sun , Yuekai Sun , Jonathan E. Taylor

While Conformal Prediction (CP) has proven to be a powerful framework for uncertainty quantification, guaranteeing conditional coverage remains a central challenge. Although finite-sample, distribution-free conditional validity is known to…

Methodology · Statistics 2026-05-27 Félix Laplante

Decision trees are widely used for non-linear modeling, as they capture interactions between predictors while producing inherently interpretable models. Despite their popularity, performing inference on the non-linear fit remains largely…

Methodology · Statistics 2026-04-14 Soham Bakshi , Snigdha Panigrahi

In estimating the average treatment effect in observational studies, the influence of confounders should be appropriately addressed. To this end, the propensity score is widely used. If the propensity scores are known for all the subjects,…

Methodology · Statistics 2023-12-08 Chengyao Tang , Yi Zhou , Ao Huang , Satoshi Hattori

Background: Existing guidelines for handling missing data are generally not consistent with the goals of prediction modelling, where missing data can occur at any stage of the model pipeline. Multiple imputation (MI), often heralded as the…

Methodology · Statistics 2022-06-27 Rose Sisk , Matthew Sperrin , Niels Peek , Maarten van Smeden , Glen P. Martin

The expense of acquiring labels in large-scale statistical machine learning makes partially and weakly-labeled data attractive, though it is not always apparent how to leverage such data for model fitting or validation. We present a…

Machine Learning · Statistics 2022-02-10 Maxime Cauchois , Suyash Gupta , Alnur Ali , John Duchi

Standard multiple testing procedures are designed to report a list of discoveries, or suspected false null hypotheses, given the hypotheses' p-values or test scores. Recently there has been a growing interest in enhancing such procedures by…

Methodology · Statistics 2025-10-29 Jack Freestone , William Stafford Noble , Uri Keich

Users increasingly expect modern search systems to offer a unified interface that seamlessly retrieves information from diverse data sources and formats. However, current information retrieval (IR) evaluation benchmarks have not kept pace…

Information Retrieval · Computer Science 2026-05-13 Mehmet Deniz Türkmen , Suchana Datta , Dwaipayan Roy , Daniel Hienert , Philipp Mayr , Derek Greene

Inference over tails is performed by applying only the results of extreme value theory. Whilst such theory is well defined and flexible enough in the univariate case, multivariate inferential methods often require the imposition of…

Methodology · Statistics 2017-08-11 Manuele Leonelli , Dani Gamerman

The availability of machine learning systems that can effectively perform arbitrary tasks has led to synthetic labels from these systems being used in applications of statistical inference, such as data analysis or model evaluation. The…

Machine Learning · Computer Science 2025-07-09 Benjamin Eyre , David Madras

Propensity score matching (PSM) has been widely used to mitigate confounding in observational studies, although complications arise when the covariates used to estimate the PS are only partially observed. Multiple imputation (MI) is a…

Applications · Statistics 2021-07-22 Albee Y. Ling , Maria E. Montez-Rath , Maya B. Mathur , Kris Kapphahn , Manisha Desai

The practice of pooling several individual test statistics to form aggregate tests is common in many statistical application where individual tests may be underpowered. While selection by aggregate tests can serve to increase power, the…

Methodology · Statistics 2020-12-08 Ruth Heller , Amit Meir , Nilanjan Chatterjee

Selective classification is a powerful tool for automated decision-making in high-risk scenarios, allowing classifiers to act only when confident and abstain when uncertainty is high. Given a target accuracy, our goal is to minimize…

Statistics Theory · Mathematics 2025-10-28 Mohamed Ndaoud , Peter Radchenko , Bradley Rava

In the partially-observed outcome setting, a recent set of proposals known as "prediction-powered inference" (PPI) involve (i) applying a pre-trained machine learning model to predict the response, and then (ii) using these predictions to…

Methodology · Statistics 2026-02-12 Runjia Zou , Daniela Witten , Brian Williamson