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Chemical reaction mechanisms are the foundation of how chemists evaluate reactivity and feasibility, yet current Computer-Assisted Synthesis Planning (CASP) systems operate without this mechanistic reasoning. We introduce a computational…

Machine Learning · Computer Science 2026-04-20 Théo A. Neukomm , Zlatko Jončev , Philippe Schwaller

Scientific texts often convey authority due to their technical language and complex data. However, this complexity can sometimes lead to the spread of misinformation. Non-experts are particularly susceptible to misleading claims based on…

Computation and Language · Computer Science 2025-06-10 Yuji Zhang , Qingyun Wang , Cheng Qian , Jiateng Liu , Chenkai Sun , Denghui Zhang , Tarek Abdelzaher , Chengxiang Zhai , Preslav Nakov , Heng Ji

With the emergence of advanced reasoning models like OpenAI o3 and DeepSeek-R1, large language models (LLMs) have demonstrated remarkable reasoning capabilities. However, their ability to perform rigorous logical reasoning remains an open…

Artificial Intelligence · Computer Science 2025-02-14 Hanmeng Liu , Zhizhang Fu , Mengru Ding , Ruoxi Ning , Chaoli Zhang , Xiaozhang Liu , Yue Zhang

The discovery of new catalysts is essential for the design of new and more efficient chemical processes in order to transition to a sustainable future. We introduce an AI-guided computational screening framework unifying linguistic…

Computational techniques are required for narrowing down the vast space of possibilities to plausible prebiotic scenarios, since precise information on the molecular composition, the dominant reaction chemistry, and the conditions for that…

Molecular Networks · Quantitative Biology 2018-02-07 Jakob L. Andersen , Christoph Flamm , Daniel Merkle , Peter F. Stadler

Large Language Models (LLMs) have achieved remarkable success and have been applied across various scientific fields, including chemistry. However, many chemical tasks require the processing of visual information, which cannot be…

Recently, there has been a surge of interest in combining deep learning models with reasoning in order to handle more sophisticated learning tasks. In many cases, a reasoning task can be solved by an iterative algorithm. This algorithm is…

Machine Learning · Computer Science 2020-11-02 Xinshi Chen , Yufei Zhang , Christoph Reisinger , Le Song

Machine Learning Interatomic Potentials play a fundamental role in computational chemistry and materials science, enabling applications from molecular dynamics simulations to drug design and materials discovery. While recent approaches can…

Machine Learning · Computer Science 2026-05-12 Amir Masoud Nourollah , Irtaza Khalid , Stefano Leoni , Steven Schockaert

Large reasoning models (LRMs) have recently demonstrated impressive capabilities in complex reasoning tasks by leveraging increased test-time computation and exhibiting behaviors reminiscent of human-like self-reflection. While LRMs show a…

Computation and Language · Computer Science 2025-10-21 Qingcheng Zeng , Weihao Xuan , Leyang Cui , Rob Voigt

Large language models (LLMs), a recent advance in deep learning and machine intelligence, have manifested astonishing capacities, now considered among the most promising for artificial general intelligence. With human-like capabilities,…

Artificial Intelligence · Computer Science 2025-09-19 Zhilun Zhou , Jing Yi Wang , Nicholas Sukiennik , Chen Gao , Fengli Xu , Yong Li , James Evans

Modern computational chemistry has reached a stage at which massive exploration into chemical reaction space with unprecedented resolution with respect to the number of potentially relevant molecular structures has become possible. Various…

Chemical Physics · Physics 2020-04-27 Jan P. Unsleber , Markus Reiher

Logic reasoning in natural language has been recognized as an important measure of human intelligence for Large Language Models (LLMs). Popular benchmarks may entangle multiple reasoning skills and thus provide unfaithful evaluations on the…

Computation and Language · Computer Science 2025-09-29 Tsz Ting Chung , Lemao Liu , Mo Yu , Dit-Yan Yeung

Deep learning has become the dominant approach for creating high capacity, scalable models across diverse data modalities. However, because these models rely on a large number of learned parameters, tightly couple feature extraction with…

Artificial Intelligence · Computer Science 2026-05-12 Adam Gould , Francesca Toni

Reasoning is a fundamental capability of large language models (LLMs), enabling them to comprehend, analyze, and solve complex problems. In this paper, we introduce TextGames, an innovative benchmark specifically crafted to assess LLMs…

Computation and Language · Computer Science 2025-02-26 Frederikus Hudi , Genta Indra Winata , Ruochen Zhang , Alham Fikri Aji

Molecular property prediction is a crucial task that guides the design of new compounds, including drugs and materials. While explainable artificial intelligence methods aim to scrutinize model predictions by identifying influential…

Machine Learning · Computer Science 2025-08-27 Łukasz Janisiów , Marek Kochańczyk , Bartosz Zieliński , Tomasz Danel

Recent advances in large language models (LLMs) have shown remarkable progress, yet their capacity for logical ``slow-thinking'' reasoning persists as a critical research frontier. Current inference scaling paradigms suffer from two…

Computation and Language · Computer Science 2025-03-21 Jinyi Liu , Yan Zheng , Rong Cheng , Qiyu Wu , Wei Guo , Fei Ni , Hebin Liang , Yifu Yuan , Hangyu Mao , Fuzheng Zhang , Jianye Hao

Machine learning (ML) has emerged into formidable force for identifying hidden but pertinent patterns within a given data set with the objective of subsequent generation of automated predictive behavior. In the recent years, it is safe to…

We mathematically prove that chemical reaction networks without hidden layers can solve tasks for which spiking neural networks require hidden layers. Our proof uses the deterministic mass-action kinetics formulation of chemical reaction…

Machine Learning · Computer Science 2026-03-13 Sophie Jaffard , Ivo F. Sbalzarini

Large language models (LLMs) have shown significant progress in reasoning tasks. However, recent studies show that transformers and LLMs fail catastrophically once reasoning problems exceed modest complexity. We revisit these findings…

Artificial Intelligence · Computer Science 2025-10-28 Revanth Rameshkumar , Jimson Huang , Yunxin Sun , Fei Xia , Abulhair Saparov

Most of the existing Large Language Model (LLM) benchmarks on scientific problem reasoning focus on problems grounded in high-school subjects and are confined to elementary algebraic operations. To systematically examine the reasoning…

Computation and Language · Computer Science 2024-07-01 Xiaoxuan Wang , Ziniu Hu , Pan Lu , Yanqiao Zhu , Jieyu Zhang , Satyen Subramaniam , Arjun R. Loomba , Shichang Zhang , Yizhou Sun , Wei Wang
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