Related papers: Tumor boundary instability induced by nutrient con…
Mechanical models of tumor growth based on a porous medium approach have been attracting a lot of interest both analytically and numerically. In this paper, we study the stability properties of a finite difference scheme for a model where…
In this paper, we study a phase-space analysis of a mathematical model of tumor growth with an immune response. Mathematical analysis of the model equations with multipoint initial condition, regarding to dissipativity, boundedness of…
In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…
Primary tumors infrequently lead to demise of cancer patients; instead, mortality and a significant degree of morbidity result from the growth of secondary tumors in distant organs (metastasis). It is well-known that malignant tumors induce…
An outstanding issue in braneworld theory concerns the setting up of proper boundary conditions for the brane-bulk system. Boundary conditions (BC's) employing regulatory branes or demanding that the bulk metric be nonsingular have yet to…
A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level. In this paper we describe a…
Microbial communities routinely have several alternative stable states observed for the same environmental parameters. Sudden and irreversible transitions between these states make external manipulation of these systems more complicated. To…
Metastatic tumors often invade healthy neighboring tissues by forming multicellular finger-like protrusions emerging from the cancer mass. To understand the mechanical context behind this phenomenon, we here develop a minimalist fluid model…
Development of resistance limits efficiency of present anticancer therapies and preventing it remains big challenge in cancer research. It is accepted, at intuitive level, that the resistance emerges as a consequence of cancer cells…
A considerable number of research works has been devoted to the study of tumor models. Several biophysical factors, such as cell proliferation, apoptosis, chemotaxis, angiogenesis and necrosis, have been discovered to have an impact on the…
We analyze a system of cross-diffusion equations that models the growth of an avascular-tumor spheroid. The model incorporates two nonlinear diffusion effects, degeneracy type and super diffusion. We prove the global existence of weak…
In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…
In this paper we study the "stiff pressure limit" of the porous medium equation, where the initial density is a bounded, integrable function with a sufficient decay at infinity. Our particular model, introduced by Perthame-Quiros-Vazquez,…
Background and Objective: In an in-vivo situation, the tissue near the blood vessels is rich in oxygen supply compared to the one far from blood vessels. Hence, non-uniform oxygen distribution is observed in biological tissues. Our…
Cancer is a heterogeneous disease and tumours of the same type can differ greatly at the genetic and phenotypic levels. Understanding how these differences impact sensitivity to treatment is an essential step towards patient-specific…
Strong experimental evidence has indicated that tumor growth belongs to the molecular beam epitaxy universality class. This type of growth is characterized by the constraint of cell proliferation to the tumor border, and surface diffusion…
Induced by proteins within the cell membrane or by differential growth, heating, or swelling, spontaneous curvatures can drastically affect the morphology of thin bodies and induce mechanical instabilities. Yet, the interaction of…
We develop a computational method for simulating the nonlinear dynamics of an elastic tumor-host interface. This work is motivated by the recent linear stability analysis of a two-phase tumor model with an elastic membrane interface in 2D.…
The proliferation and migration dichotomy of the tumor cell invasion is examined within a two-component continuous time random walk (CTRW) model. The balance equations for the cancer cells of two phenotypes with random switching between…
A systematic understanding of the evolution and growth dynamics of invasive solid tumors in response to different chemotherapy strategies is crucial for the development of individually optimized oncotherapy. Here, we develop a hybrid…