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Tracking single molecules is instrumental for quantifying the transport of molecules and nanoparticles in biological samples, e.g., in brain drug delivery studies. Existing intensity-based localisation methods are not developed for imaging…

Recent developments have created differentiable physics simulators designed for machine learning pipelines that can be accelerated on a GPU. While these can simulate biomechanical models, these opportunities have not been exploited for…

Computer Vision and Pattern Recognition · Computer Science 2024-02-28 R. James Cotton

As deep neural networks require tremendous amount of computation and memory, analog computing with emerging memory devices is a promising alternative to digital computing for edge devices. However, because of the increasing simulation time…

Machine Learning · Computer Science 2021-01-21 Chaeun Lee , Seyoung Kim

The dynamics of physical systems is often constrained to lower dimensional sub-spaces due to the presence of conserved quantities. Here we propose a method to learn and exploit such symmetry constraints building upon Hamiltonian Neural…

Machine Learning · Computer Science 2021-04-30 Marc Syvaeri , Sven Krippendorf

Computer simulations are invaluable tools for scientific discovery. However, accurate simulations are often slow to execute, which limits their applicability to extensive parameter exploration, large-scale data analysis, and uncertainty…

Unraveling the dynamical motions of biomolecules is essential for bridging their structure and function, yet it remains a major computational challenge. Molecular dynamics (MD) simulation provides a detailed depiction of biomolecular…

Biomolecules · Quantitative Biology 2025-09-17 Allan dos Santos Costa , Manvitha Ponnapati , Dana Rubin , Tess Smidt , Joseph Jacobson

Machine learning has become increasingly popular for efficiently modelling the dynamics of complex physical systems, demonstrating a capability to learn effective models for dynamics which ignore redundant degrees of freedom. Learned…

Machine Learning · Computer Science 2022-11-29 Ameya Daigavane , Arthur Kosmala , Miles Cranmer , Tess Smidt , Shirley Ho

Efficient radio packet scheduling remains one of the most challenging tasks in cellular networks, and while heuristic methods exist, practical deep learning-based schedulers that are 3GPP-compliant and capable of real-time operation in 5G…

Signal Processing · Electrical Eng. & Systems 2025-10-10 Petteri Kela , Bryan Liu , Alvaro Valcarce

Simulation is a useful tool in situations where training data for machine learning models is costly to annotate or even hard to acquire. In this work, we propose a reinforcement learning-based method for automatically adjusting the…

Machine Learning · Computer Science 2019-05-15 Nataniel Ruiz , Samuel Schulter , Manmohan Chandraker

Molecular dynamics simulations have been extensively used to predict thermal properties, but simulating different phases with similar precision using a unified force field is often difficult, due to the lack of accurate and transferrable…

Materials Science · Physics 2019-12-12 Ruiyang Li , Eungkyu Lee , Tengfei Luo

Computing properties of molecular systems rely on estimating expectations of the (unnormalized) Boltzmann distribution. Molecular dynamics (MD) is a broadly adopted technique to approximate such quantities. However, stable simulations rely…

Chemical Physics · Physics 2023-10-31 Mathias Schreiner , Ole Winther , Simon Olsson

Simulators based on neural networks offer a path to orders-of-magnitude faster electromagnetic wave simulations. Existing models, however, only address narrowly tailored classes of problems and only scale to systems of a few dozen degrees…

Optics · Physics 2024-04-02 Charles Dove , Jatearoon Boondicharern , Laura Waller

The proposed stochastic model for pedestrian dynamics is based on existing approaches using cellular automata, combined with substantial extensions, to compensate the deficiencies resulting of the discrete grid structure. This agent motion…

Physics and Society · Physics 2021-04-01 Michael Schultz

Simulating the long-timescale dynamics of biomolecules is a central challenge in computational science. While enhanced sampling methods can accelerate these simulations, they rely on pre-defined collective variables that are often difficult…

Biomolecules · Quantitative Biology 2025-12-01 Aditya Sengar , Jiying Zhang , Pierre Vandergheynst , Patrick Barth

Multiscale is a hallmark feature of complex nonlinear systems. While the simulation using the classical numerical methods is restricted by the local \textit{Taylor} series constraints, the multiscale techniques are often limited by finding…

Dynamical Systems · Mathematics 2024-05-07 Asif Hamid , Danish Rafiq , Shahkar Ahmad Nahvi , Mohammad Abid Bazaz

When modeling such phenomena as population dynamics, controllable ows, etc., a problem arises of adapting the existing models to a phenomenon under study. For this purpose, we propose to derive new models from the rst principles by…

Symbolic Computation · Computer Science 2018-05-09 D. S. Kulyabov , M. N. Gevorkyan , A. V. Demidova , T. R. Velieva , A. V. Korolkova , L. A. Sevastianov

Determining the different conformational states of a protein and the transition paths between them is key to fully understanding the relationship between biomolecular structure and function. This can be accomplished by sampling protein…

Biological Physics · Physics 2021-03-24 Venkata K. Ramaswamy , Chris G. Willcocks , Matteo T. Degiacomi

The next generation of force fields for molecular dynamics will be developed using a wealth of data. Training systematically with experimental data remains a challenge, however, especially for machine learning potentials. Differentiable…

Biomolecules · Quantitative Biology 2025-04-16 Joe G Greener

Autonomous navigation in complex and partially observable environments remains a central challenge in robotics. Several bio-inspired models of mapping and navigation based on place cells in the mammalian hippocampus have been proposed. This…

Neural and Evolutionary Computing · Computer Science 2026-01-08 Bekarys Dukenbaev , Andrew Gerstenslager , Alexander Johnson , Ali A. Minai

The dynamic behaviour of a power system can be described by a system of differential-algebraic equations. Time-domain simulations are used to simulate the evolution of these dynamics. They often require the use of small time step sizes and…

Systems and Control · Electrical Eng. & Systems 2024-07-08 Jochen Stiasny , Baosen Zhang , Spyros Chatzivasileiadis