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Biomedical research has revealed the crucial role of miRNAs in the progression of many diseases, and computational prediction methods are increasingly proposed for assisting biological experiments to verify miRNA-disease associations…

Computational Engineering, Finance, and Science · Computer Science 2023-08-29 Yi Zhou , Meixuan Wu , Chengzhou Ouyang , Min Zhu

Federated learning (FL) has emerged as a key technique for distributed machine learning (ML). Most literature on FL has focused on ML model training for (i) a single task/model, with (ii) a synchronous scheme for updating model parameters,…

Machine Learning · Computer Science 2024-02-19 Zhan-Lun Chang , Seyyedali Hosseinalipour , Mung Chiang , Christopher G. Brinton

Federated learning has emerged as a paradigm to train models collaboratively on inherently distributed client data while safeguarding privacy. In this context, personalized federated learning tackles the challenge of data heterogeneity by…

Machine Learning · Computer Science 2026-03-13 Peng Hu , Jianwei Ma

Motivated by distributed machine learning settings such as Federated Learning, we consider the problem of fitting a statistical model across a distributed collection of heterogeneous data sets whose similarity structure is encoded by a…

Statistics Theory · Mathematics 2021-11-30 Dominic Richards , Sahand N. Negahban , Patrick Rebeschini

Federated learning allows us to run machine learning algorithms on decentralized data when data sharing is not permitted due to privacy concerns. Ensemble-based learning works by training multiple (weak) classifiers whose output is…

Machine Learning · Computer Science 2024-02-20 Florian van Daalen , Lianne Ippel , Andre Dekker , Inigo Bermejo

Federated learning (FL) is an approach to training machine learning models that takes advantage of multiple distributed datasets while maintaining data privacy and reducing communication costs associated with sharing local datasets.…

Machine Learning · Computer Science 2024-12-06 John Fischer , Marko Orescanin , Justin Loomis , Patrick McClure

Federated graph learning (FGL) enables multiple clients to collaboratively train powerful graph neural networks without sharing their private, decentralized graph data. Inherited from generic federated learning, FGL is critically challenged…

Machine Learning · Computer Science 2025-08-15 Xinrui Li , Qilin Fan , Tianfu Wang , Kaiwen Wei , Ke Yu , Xu Zhang

In genome wide association studies (GWAS), researchers are often dealing with non-normally distributed traits or a mixture of discrete-continuous traits. However, most of the current region-based methods rely on multivariate linear mixed…

Methodology · Statistics 2021-09-30 Julien St-Pierre , Karim Oualkacha

Federated learning achieves joint training of deep models by connecting decentralized data sources, which can significantly mitigate the risk of privacy leakage. However, in a more general case, the distributions of labels among clients are…

Machine Learning · Computer Science 2022-12-20 Tao Sheng , Chengchao Shen , Yuan Liu , Yeyu Ou , Zhe Qu , Jianxin Wang

In this paper, we explore a new knowledge-amalgamation problem, termed Federated Selective Aggregation (FedSA). The goal of FedSA is to train a student model for a new task with the help of several decentralized teachers, whose pre-training…

Computer Vision and Pattern Recognition · Computer Science 2022-07-28 Donglin Xie , Ruonan Yu , Gongfan Fang , Jie Song , Zunlei Feng , Xinchao Wang , Li Sun , Mingli Song

Multivariate linear mixed models (mvLMMs) have been widely used in many areas of genetics, and have attracted considerable recent interest in genome-wide association studies (GWASs). However, fitting mvLMMs is computationally non-trivial,…

Quantitative Methods · Quantitative Biology 2013-09-13 Xiang Zhou , Matthew Stephens

Major advances have been made regarding the utilization of artificial intelligence in health care. In particular, deep learning approaches have been successfully applied for automated and assisted disease diagnosis and prognosis based on…

Methodology · Statistics 2020-03-24 Max Westphal , Antonia Zapf , Werner Brannath

Federated learning (FL) allows for collaborative model training across decentralized clients while preserving privacy by avoiding data sharing. However, current FL methods assume conditional independence between client models, limiting the…

Machine Learning · Statistics 2024-05-28 Conor Hassan , Joshua J Bon , Elizaveta Semenova , Antonietta Mira , Kerrie Mengersen

We propose an asymptotic framework to analyze the performance of (personalized) federated learning algorithms. In this new framework, we formulate federated learning as a multi-criterion objective, where the goal is to minimize each…

Machine Learning · Computer Science 2022-02-21 Gary Cheng , Karan Chadha , John Duchi

Federated Learning enables collaborative model training without centralising data, but its effectiveness varies with the selection of the aggregation strategy. This choice is non-trivial, as performance varies widely across datasets,…

Machine Learning · Computer Science 2026-04-10 Dian S. Y. Pang , Endrias Y. Ergetu , Eric Topham , Ahmed E. Fetit

Deep learning-based methods have achieved encouraging performances in the field of magnetic resonance (MR) image reconstruction. Nevertheless, to properly learn a powerful and robust model, these methods generally require large quantities…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Ruoyou Wu , Cheng Li , Juan Zou , Qiegen Liu , Hairong Zheng , Shanshan Wang

In genetic association studies, detecting phenotype-genotype association is a primary goal. We assume that the relationship between the data -phenotype, genetic markers and environmental covariates - can be modelled by a generalized linear…

Methodology · Statistics 2020-04-13 K. K. Halle , Ø. Bakke , S. Djurovic , A. Bye , E. Ryeng , U. Wisløff , O. A. Andreassen , M. Langaas

Statistical ensembles of networks, i.e., probability spaces of all networks that are consistent with given aggregate statistics, have become instrumental in the analysis of complex networks. Their numerical and analytical study provides the…

Physics and Society · Physics 2016-08-09 Giona Casiraghi , Vahan Nanumyan , Ingo Scholtes , Frank Schweitzer

Computer-aided diagnosis (CAD) systems play a crucial role in analyzing neuroimaging data for neurological and psychiatric disorders. However, small-sample studies suffer from low reproducibility, while large-scale datasets introduce…

Machine Learning · Computer Science 2025-08-12 Xinglin Zhao , Yanwen Wang , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Selecting the best data mixture is critical for successful Supervised Fine-Tuning (SFT) of Multimodal Large Language Models. However, determining the optimal mixture weights across multiple domain-specific datasets remains a significant…

Machine Learning · Computer Science 2026-02-06 Davide Berasi , Matteo Farina , Massimiliano Mancini , Elisa Ricci