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Federated Learning has been recently proposed for distributed model training at the edge. The principle of this approach is to aggregate models learned on distributed clients to obtain a new more general "average" model (FedAvg). The…

Machine Learning · Statistics 2022-07-20 Adnan Ben Mansour , Gaia Carenini , Alexandre Duplessis , David Naccache

Federated Learning (FL) allows collaborative training while ensuring data privacy across distributed edge devices, making it a popular solution for privacy-sensitive applications. However, FL faces significant challenges due to statistical…

Machine Learning · Computer Science 2025-05-16 Huy Q. Le , Latif U. Khan , Choong Seon Hong

Federated recommendation (FR) facilitates collaborative training by aggregating local models from massive devices, enabling client-specific personalization while ensuring privacy. However, we empirically and theoretically demonstrate that…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-08-19 Jundong Chen , Honglei Zhang , Chunxu Zhang , Fangyuan Luo , Yidong Li

Deep learning models can enable accurate and efficient disease diagnosis, but have thus far been hampered by the data scarcity present in the medical world. Automated diagnosis studies have been constrained by underpowered single-center…

Image and Video Processing · Electrical Eng. & Systems 2022-03-04 Akis Linardos , Kaisar Kushibar , Sean Walsh , Polyxeni Gkontra , Karim Lekadir

We are interested in estimating the effect of a treatment applied to individuals at multiple sites, where data is stored locally for each site. Due to privacy constraints, individual-level data cannot be shared across sites; the sites may…

Machine Learning · Computer Science 2023-04-04 Ruoxuan Xiong , Allison Koenecke , Michael Powell , Zhu Shen , Joshua T. Vogelstein , Susan Athey

The standard methods for detecting differential gene expression are mostly designed for analyzing a single gene expression experiment. When data from multiple related gene expression studies are available, separately analyzing each study is…

Methodology · Statistics 2013-11-07 Yingying Wei , Hongkai Ji

In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent…

Methodology · Statistics 2019-03-27 Naim U. Rashid , Quefeng Li , Jen Jen Yeh , Joseph G. Ibrahim

Sequencing-based studies are emerging as a major tool for genetic association studies of complex diseases. These studies pose great challenges to the traditional statistical methods (e.g., single-locus analyses based on regression methods)…

Methodology · Statistics 2025-08-18 Changshuai Wei , Qing Lu

In the medical field, federated learning commonly deals with highly imbalanced datasets, including skin lesions and gastrointestinal images. Existing federated methods under highly imbalanced datasets primarily focus on optimizing a global…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Marawan Elbatel , Hualiang Wang , Robert Martí , Huazhu Fu , Xiaomeng Li

The age of big data has fueled expectations for accelerating learning. The availability of large data sets enables researchers to achieve more powerful statistical analyses and enhances the reliability of conclusions, which can be based on…

Methodology · Statistics 2023-08-22 Ori Becher , Mira Marcus-Kalish , David M. Steinberg

Federated learning enables multiple institutions to collaboratively train machine learning models on their local data in a privacy-preserving way. However, its distributed nature often leads to significant heterogeneity in data…

Machine Learning · Computer Science 2021-07-20 Liangqiong Qu , Niranjan Balachandar , Daniel L Rubin

Exploiting deep learning in medical imaging faces critical challenges, including strict privacy constraints, heterogeneous imaging devices with varying acquisition properties, and class imbalance due to the uneven prevalence of pathologies.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Martina Pavan , Matteo Caligiuri , Francesco Barbato , Pietro Zanuttigh

The recent trend towards Personalized Federated Learning (PFL) has garnered significant attention as it allows for the training of models that are tailored to each client while maintaining data privacy. However, current PFL techniques…

Machine Learning · Computer Science 2023-05-03 Yue Wu , Shuaicheng Zhang , Wenchao Yu , Yanchi Liu , Quanquan Gu , Dawei Zhou , Haifeng Chen , Wei Cheng

The rapid growth of Internet of Things (IoT) devices has generated vast amounts of data, leading to the emergence of federated learning as a novel distributed machine learning paradigm. Federated learning enables model training at the edge,…

Signal Processing · Electrical Eng. & Systems 2023-11-03 Abdelaziz Salama , Achilleas Stergioulis , Syed Ali Zaidi , Des McLernon

Federated Learning (FL) is an emerging framework for distributed processing of large data volumes by edge devices subject to limited communication bandwidths, heterogeneity in data distributions and computational resources, as well as…

Machine Learning · Computer Science 2022-04-11 Yonghai Gong , Yichuan Li , Nikolaos M. Freris

In medical research, individual-level patient data provide invaluable information, but the patients' right to confidentiality remains of utmost priority. This poses a huge challenge when estimating statistical models such as linear mixed…

Methodology · Statistics 2025-01-24 Marie Analiz April Limpoco , Christel Faes , Niel Hens

Federated learning is a collaborative model training method that iterates model updates by multiple clients and aggregation of the updates by a central server. Device and statistical heterogeneity of participating clients cause significant…

Machine Learning · Computer Science 2023-08-29 Ayano Nakai-Kasai , Tadashi Wadayama

This study analyzes the performance of domain-specific Large Language Models (LLMs) for the medical field by integrating Retrieval-Augmented Generation (RAG) systems within a federated learning framework. Leveraging the inherent advantages…

Computation and Language · Computer Science 2025-01-09 Jincheol Jung , Hongju Jeong , Eui-Nam Huh

As Large Language Models (LLMs) push the boundaries of AI capabilities, their demand for data is growing. Much of this data is private and distributed across edge devices, making Federated Learning (FL) a de-facto alternative for…

Machine Learning · Computer Science 2024-08-22 Hanzi Mei , Dongqi Cai , Ao Zhou , Shangguang Wang , Mengwei Xu

To improve business efficiency and minimize costs, Artificial Intelligence (AI) practitioners have adopted a shift from formulating models from scratch towards sharing pretrained models. The pretrained models are then aggregated into a…

Neural and Evolutionary Computing · Computer Science 2025-05-12 Anthony Kiggundu , Dennis Krummacker , Hans D. Schotten