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This paper considers neural representation through the lens of active inference, a normative framework for understanding brain function. It delves into how living organisms employ generative models to minimize the discrepancy between…

Neurons and Cognition · Quantitative Biology 2023-10-24 Giovanni Pezzulo , Leo D'Amato , Francesco Mannella , Matteo Priorelli , Toon Van de Maele , Ivilin Peev Stoianov , Karl Friston

Mounting evidence in neuroscience suggests the possibility of neuronal representations that individual neurons serve as the substrates of different mental representations in a point-to-point way. Combined with associationism, it can…

Neurons and Cognition · Quantitative Biology 2021-09-06 Chiyin Zheng

Grid cells in the entorhinal cortex fire when animals that are exploring a certain region of space occupy the vertices of a triangular grid that spans the environment. Different neurons feature triangular grids that differ in their…

Neurons and Cognition · Quantitative Biology 2017-01-04 Alessandro Sanzeni , Vijay Balasubramanian , Guido Tiana , Massimo Vergassola

Neurons in the brain are often finely tuned for specific task variables. Moreover, such disentangled representations are highly sought after in machine learning. Here we mathematically prove that simple biological constraints on neurons,…

Neurons and Cognition · Quantitative Biology 2023-04-04 James C. R. Whittington , Will Dorrell , Surya Ganguli , Timothy E. J. Behrens

This paper proposes a representational model for grid cells. In this model, the 2D self-position of the agent is represented by a high-dimensional vector, and the 2D self-motion or displacement of the agent is represented by a matrix that…

Machine Learning · Statistics 2019-05-28 Ruiqi Gao , Jianwen Xie , Song-Chun Zhu , Ying Nian Wu

Behavioral flexibility is learning from previous experiences and planning appropriate actions in a changing or novel environment. Successful behavioral adaptation depends on internal models the brain builds to represent the relational…

Neurons and Cognition · Quantitative Biology 2021-07-01 Linda Q. Yu , Seongmin A. Park , Sarah C. Sweigart , Erie D. Boorman , Matthew R. Nassar

For 20 years the beautiful structure in the grid cell code has presented an attractive puzzle: what computation do these representations subserve, and why does it manifest so curiously in neurons. The first question quickly attracted an…

Neurons and Cognition · Quantitative Biology 2026-03-06 William Dorrell , James C. R. Whittington

Grid cells are believed to play an important role in both spatial and non-spatial cognition tasks. A recent study observed the emergence of grid cells in an LSTM for path integration. The connection between biological and artificial neural…

Neurons and Cognition · Quantitative Biology 2020-09-10 Li Songlin , Deng Yangdong , Wang Zhihua

Grid cells in the brain respond when an animal occupies a periodic lattice of "grid fields" during spatial navigation. The grid scale varies along the dorso-ventral axis of the entorhinal cortex. We propose that the grid system minimizes…

Neurons and Cognition · Quantitative Biology 2018-05-14 Xue-Xin Wei , Jason Prentice , Vijay Balasubramanian

This paper investigates the conformal isometry hypothesis as a potential explanation for the hexagonal periodic patterns in grid cell response maps. We posit that grid cell activities form a high-dimensional vector in neural space, encoding…

Neurons and Cognition · Quantitative Biology 2025-02-28 Dehong Xu , Ruiqi Gao , Wen-Hao Zhang , Xue-Xin Wei , Ying Nian Wu

Grid cells in the entorhinal cortex of mammalian brains exhibit striking hexagon grid firing patterns in their response maps as the animal (e.g., a rat) navigates in a 2D open environment. In this paper, we study the emergence of the…

Neurons and Cognition · Quantitative Biology 2024-02-21 Dehong Xu , Ruiqi Gao , Wen-Hao Zhang , Xue-Xin Wei , Ying Nian Wu

Representation learning is a central challenge across a range of machine learning areas. In reinforcement learning, effective and functional representations have the potential to tremendously accelerate learning progress and solve more…

Machine Learning · Computer Science 2019-01-30 Dibya Ghosh , Abhishek Gupta , Sergey Levine

Grid cells in the medial entorhinal cortex (MEC) of the mammalian brain exhibit a strikingly regular hexagonal firing field over space. These cells are learned after birth and are thought to support spatial navigation but also more abstract…

Neurons and Cognition · Quantitative Biology 2024-10-07 Mufeng Tang , Helen Barron , Rafal Bogacz

Grid cells enable the brain to model the physical space of the world and navigate effectively via path integration, updating self-position using information from self-movement. Recent proposals suggest that the brain might use similar…

Artificial Intelligence · Computer Science 2021-02-19 Niels Leadholm , Marcus Lewis , Subutai Ahmad

Understanding how grid cells perform path integration calculations remains a fundamental problem. In this paper, we conduct theoretical analysis of a general representation model of path integration by grid cells, where the 2D self-position…

Neurons and Cognition · Quantitative Biology 2021-11-04 Ruiqi Gao , Jianwen Xie , Xue-Xin Wei , Song-Chun Zhu , Ying Nian Wu

Decades of research on the neural code underlying spatial navigation have revealed a diverse set of neural response properties. The Entorhinal Cortex (EC) of the mammalian brain contains a rich set of spatial correlates, including grid…

Neurons and Cognition · Quantitative Biology 2018-05-11 Christopher J. Cueva , Xue-Xin Wei

Grid cells, discovered more than a decade ago [5], are neurons in the brain of mammals that fire when the animal is located near certain specific points in its familiar terrain. Intriguingly, these points form, for a single cell, a…

Neurons and Cognition · Quantitative Biology 2016-06-16 Christos H. Papadimitriou

Does the brain construct an efficient representation of the sensory world? We review progress on this question, focusing on a series of experiments in the last decade which use fly vision as a model system in which theory and experiment can…

Neurons and Cognition · Quantitative Biology 2007-12-31 William Bialek , Rob R. de Ruyter van Steveninck , Naftali Tishby

Grid cells in the entorhinal cortex, together with head direction, place, speed and border cells, are major contributors to the organization of spatial representations in the brain. In this work we introduce a novel theoretical and…

Neurons and Cognition · Quantitative Biology 2019-07-25 Fabio Anselmi , Micah M. Murray , Benedetta Franceschiello

Flexible, goal-directed behavior is a fundamental aspect of human life. Based on the free energy minimization principle, the theory of active inference formalizes the generation of such behavior from a computational neuroscience…

Artificial Intelligence · Computer Science 2022-08-03 Fedor Scholz , Christian Gumbsch , Sebastian Otte , Martin V. Butz
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