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Constraints make hard optimization problems even harder to solve on quantum devices because they are implemented with large energy penalties and additional qubit overhead. The parity mapping, which has been introduced as an alternative to…

Quantum Physics · Physics 2023-03-20 Maike Drieb-Schön , Kilian Ender , Younes Javanmard , Wolfgang Lechner

We introduce a manifold-based framework for addressing optimization problems with equality and inequality constraints found in robotics. Our approach transforms the original problem into an unconstrained optimization problem directly on the…

Robotics · Computer Science 2026-05-21 Yetong Zhang , Frank Dellaert

The Quadratic Unconstrained Binary Optimization problem (QUBO) has become a unifying model for representing a wide range of combinatorial optimization problems, and for linking a variety of disciplines that face these problems. A new class…

Artificial Intelligence · Computer Science 2017-05-30 Mark Lewis , Fred Glover

The quantum approximate optimization algorithm (QAOA) is a hybrid variational quantum-classical algorithm that solves combinatorial optimization problems. While there is evidence suggesting that the fixed form of the standard QAOA ansatz is…

One of the major application areas of interest for both near-term and fault-tolerant quantum computers is the optimization of classical objective functions. In this work, we develop intuitive constructions for a large class of these…

Many combinatorial optimization problems admit a maximin fairness variant, where the aim is to find a distribution over possible solutions which maximizes an expected worst-case outcome. However, the support for an optimal distribution may…

Quantum Physics · Physics 2026-04-17 Bao Bach , Cameron Ibrahim , Reuben Tate , Jad Salem , Stephan Eidenbenz , Ilya Safro

Combinatorial optimization problems on graphs have broad applications in science and engineering. The Quantum Approximate Optimization Algorithm (QAOA) is a method to solve these problems on a quantum computer by applying multiple rounds of…

Quantum computers are expected to offer significant advantages in solving complex optimization problems that are challenging for classical computers. Quadratic Unconstrained Binary Optimization (QUBO) problems represent an important class…

Quantum Physics · Physics 2025-10-15 Teemu Pihkakoski , Aravind Plathanam Babu , Pauli Taipale , Petri Liimatta , Matti Silveri

Quantum computing offers significant potential for solving NP-hard combinatorial (optimization) problems that are beyond the reach of classical computers. One way to tap into this potential is by reformulating combinatorial problems as a…

We study fundamental limitations of the generic Quantum Approximate Optimization Algorithm (QAOA) on constrained problems where valid solutions form a low dimensional manifold inside the Boolean hypercube, and we present a provable route to…

Quantum Physics · Physics 2026-04-30 Chinonso Onah , Kristel Michielsen

Quantum computing promises significant speed-ups for certain algorithms but the practical use of current noisy intermediate-scale quantum (NISQ) era computers remains limited by resources constraints (e.g., noise, qubits, gates, and circuit…

Quantum Physics · Physics 2026-03-31 Tobias Fischbach , Pierre Talbot , Pascal Bouvry

This paper introduces two techniques that make the standard Quantum Approximate Optimization Algorithm (QAOA) more suitable for constrained optimization problems. The first technique describes how to use the outcome of a prior greedy…

Quantum Physics · Physics 2022-02-07 Wim van Dam , Karim Eldefrawy , Nicholas Genise , Natalie Parham

Recent technological developments have focused the interest of the quantum computing community on investigating how near-term devices could outperform classical computers for practical applications. A central question that remains open is…

Quantum Physics · Physics 2021-11-24 Daniel Stilck Franca , Raul Garcia-Patron

Optimizing the mRNA codon has an essential impact on gene expression for a specific target protein. It is an NP-hard problem; thus, exact solutions to such optimization problems become computationally intractable for realistic problem sizes…

Quantum Physics · Physics 2024-05-13 Hongfeng Zhang , Aritra Sarkar , Koen Bertels

The LogQ algorithm encodes Quadratic Unconstrained Binary Optimization (QUBO) problems with exponentially fewer qubits than the Quantum Approximate Optimization Algorithm (QAOA). The advantages of conventional LogQ are accompanied by a…

Quantum Physics · Physics 2025-07-14 Yagnik Chatterjee , Jérémie Messud

Computational methods are the most effective tools we have besides scientific experiments to explore the properties of complex biological systems. Progress is slowing because digital silicon computers have reached their limits in terms of…

Quantum Physics · Physics 2020-04-03 Viv Kendon

Quantum optimization has emerged as a promising frontier of quantum computing, providing novel numerical approaches to mathematical optimization problems. The main goal of this paper is to facilitate interdisciplinary research between the…

Optimization and Control · Mathematics 2025-09-05 Alexey Bochkarev , Raoul Heese , Sven Jäger , Philine Schiewe , Anita Schöbel

The broad applicability of Quadratic Unconstrained Binary Optimization (QUBO) constitutes a general-purpose modeling framework for combinatorial optimization problems and are a required format for gate array and quantum annealing computers.…

Artificial Intelligence · Computer Science 2021-04-06 Amit Verma , Mark Lewis

Quadratic unconstrained binary optimization (QUBO) has become the standard format for optimization using quantum computers, i.e., for both the quantum approximate optimization algorithm (QAOA) and quantum annealing (QA). We present a…

Quantum Physics · Physics 2022-04-26 Thomas Gabor , Marian Lingsch Rosenfeld , Sebastian Feld , Claudia Linnhoff-Popien

Recent advances in quantum computing and the increasing availability of quantum hardware have substantially enhanced the practical relevance of quantum approaches to discrete optimization. Among these, the Quadratic Unconstrained Binary…

Quantum Physics · Physics 2026-02-12 Felix P. Broesamle , Stefan Nickel
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