Related papers: Predicting cell stress and strain during extrusion…
The balance between stretching and bending deformations characterizes shape transitions of thin elastic sheets. While stretching dominates the mechanical response in tension, bending dominates in compression after an abrupt buckling…
The folding of cellular monolayers pervades embryonic development and disease. It results from stresses out of the plane of the tissue, often caused by cell shape changes including cell wedging via apical constriction. These local cellular…
In cell extrusion, a cell embedded in an epithelial monolayer loses its apical or basal surface and is subsequently squeezed out of the monolayer by neighboring cells. Cell extrusions occur during apoptosis, epithelial-mesenchymal…
We use a custom shear cell coupled to an optical microscope to investigate at the particle level the yielding transition in concentrated emulsions subjected to an oscillatory shear deformation. By performing experiments lasting thousands of…
Active nematic models explain the topological defects and flow patterns observed in epithelial tissues, but the nature of active stress-whether it is extensile or contractile, a key parameter of the theory-is not well established…
In this paper, we seek to model the deformation of nucleated cells by single diode-laser bar optical stretchers. We employ a recently developed computational model, the Dynamic Ray-Tracing method, to determine the stress distribution…
Stress transmission in realistic granular media often occurs under external load and in the presence of boundary slip. We investigate shear localization in a split-bottom Couette cell with smooth walls subject to a confining pressure…
We analyze fluctuations of particle displacements and stresses in a sheared athermal suspension of elastic capsules (red blood cells). Upon variation of the volume fraction from the dilute up to the highly concentrated regime, our numerical…
Extrusion-based 3D printing is a widely utilized tool in tissue engineering, offering precise 3D control of bioinks to construct organ-sized biomaterial objects with hierarchically organized cellularized scaffolds. The internal organization…
This study presents the spreading of a single filament of a yield stress (viscoplastic) fluid extruded onto a pre-wetted solid surface. The filaments spread laterally under surface tension forces until they reach a final equilibrium shape…
In this paper, we obtain analytical results for shear stress distributions inside an elastic body placed in a low Reynolds number transport. The problem definition is inspired by a recent experimental study (Valiei et al., Lab Chip, 2012,…
In a pouch cell battery, the intercalation of lithium ions into the active particles means the electrodes want to expand. However, since the electrodes are attached to stiff current collectors, this expansion is constrained, leading to a…
We experimentally and numerically investigate the flow of a Newtonian fluid through a constricted geometry for Reynolds numbers in the range $0.1 - 100$. The major aim is to study non-linear inertia effects at larger Reynolds numbers (>10)…
Soft particles suspended in fluids flowing through microchannels are often encountered in biological flows such as cells in vessels. They can deform under flow or when subject to mechanical stresses as they interact with themselves.…
We develop and thoroughly test a stress-controlled, parallel plates shear cell that can be coupled to an optical microscope or a small angle light scattering setup, for simultaneous investigation of the rheological properties and the…
Initial residual stress is omnipresent in biological tissues and soft matter, and can affect growth-induced pattern selection significantly. Here we demonstrate this effect experimentally by letting soft tubes grow in the presence or…
3D printing methods which enable control over the position and orientation of embedded particles have promising applications in cell patterning and composite scaffolds. Extrusion-based additive manufacturing techniques such as fused…
Angular channel extrusion has evolved as processes that can induce significant strengthening of the formed product through grain refinement. However, significant residual stresses are developed in the extruded product whose quantification…
Extrusion is a widely used process for forming pastes into designed shapes, and is central to the manufacture of many industrial products. The extrusion through a square-entry die of a model paste of non-Brownian spheres suspended in a…
Living active collectives have evolved with remarkable self-patterning ability to meet the physical and biological constraints for growth and survival. However, how complex multicellular patterns emerge from a single founder cell remains…