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Biological soft tissues exhibit substantial inter-subject variability, making the automation of constitutive material modeling essential for patient-specific analysis and design. Such materials are not only highly nonlinear but also display…

Computational Physics · Physics 2026-04-16 Bahador Bahmani

We review nine invariant and dispersion-type anisotropic hyperelastic constitutive models for soft biological tissues based on their fitting performance to experimental data from three different human tissues. For this, we used a hybrid…

Numerical Analysis · Mathematics 2022-07-29 Hüsnü Dal , Alp Kağan Açan , Ciara Durcan , Mokarram Hossain

This work presents a novel approach for characterizing the mechanical behavior of atrial tissue using constitutive neural networks. Based on experimental biaxial tensile test data of healthy human atria, we automatically discover the most…

Computational Engineering, Finance, and Science · Computer Science 2025-04-04 Mathias Peirlinck , Kevin Linka , Ellen Kuhl

The high-fidelity characterization of soft, tissue-like materials under ultra-high-strain-rate conditions is critical in engineering and medicine. Still, it remains challenging due to limited optical access, sensitivity to initial…

When characterizing materials, it can be important to not only predict their mechanical properties, but also to estimate the probability distribution of these properties across a set of samples. Constitutive neural networks allow for the…

Computational Engineering, Finance, and Science · Computer Science 2025-03-18 Jeremy A. McCulloch , Ellen Kuhl

Cardiac muscle tissue exhibits highly non-linear hyperelastic and orthotropic material behavior during passive deformation. Traditional constitutive identification protocols therefore combine multiple loading modes and typically require…

Tissues and Organs · Quantitative Biology 2026-05-05 Rogier P. Krijnen , Akshay Joshi , Siddhant Kumar , Mathias Peirlinck

In this study, a stochastic constitutive modeling approach for elastomeric materials is developed to consider uncertainty in material behavior and its prediction. This effort leads to a demonstration of the deterministic approaches error…

Soft Condensed Matter · Physics 2020-10-27 Aref Ghaderi , Vahid Morovati , Roozbeh Dargazany

The paper provides a macro-microscopic coupled constitutive model for fluid-saturated porous media with respect to the compressibility of the solid skeleton, the real solid material and the fluid phase. The derivation of the model is…

Geophysics · Physics 2022-04-27 Jia-Yu Liang , Yue-Ming Li , Erich Bauer

This paper develops new insights into quantitative methods for the validation of computational model prediction. Four types of methods are investigated, namely classical and Bayesian hypothesis testing, a reliability-based method, and an…

Data Analysis, Statistics and Probability · Physics 2012-06-25 You Ling , Sankaran Mahadevan

Data-based approaches are promising alternatives to the traditional analytical constitutive models for solid mechanics. Herein, we propose a Gaussian process (GP) based constitutive modeling framework, specifically focusing on planar,…

Computational Engineering, Finance, and Science · Computer Science 2022-12-13 Ankush Aggarwal , Bjørn Sand Jensen , Sanjay Pant , Chung-Hao Lee

Constitutive models that describe the mechanical behavior of soft tissues have advanced greatly over the past few decades. These expert models are generalizable and require the calibration of a number of parameters to fit experimental data.…

Quantitative Methods · Quantitative Biology 2021-07-13 Vahidullah Tac , Vivek D. Sree , Manuel K. Rausch , Adrian B. Tepole

Combining microstructural mechanical models with experimental data enhances our understanding of the mechanics of soft tissue, such as tendons. In previous work, a Bayesian framework was used to infer constitutive parameters from uniaxial…

Applications · Statistics 2025-08-25 James Casey , Jessica Forsyth , Timothy Waite , Simon Cotter , Tom Shearer

We propose a Bayesian variable selection method in the framework of modal regression for heavy-tailed responses. An efficient expectation-maximization algorithm is employed to expedite parameter estimation. A test statistic is constructed…

Methodology · Statistics 2025-10-29 Jiasong Duan , Hongmei Zhang , Xianzheng Huang

The viscoelastic properties of arterial tissue dictate vessel behavior in certain disease states, injury modalities, and during some endovascular procedures. In this study, we characterized the viscoelastic mechanical response of porcine…

In this paper, we present an approach for modeling bio-tissues that incorporates the variability in properties as part of their characteristics. This is achieved by considering the parameters of the model of a biomaterial to themselves be…

Tissues and Organs · Quantitative Biology 2013-12-11 Srikrishna Doraiswamy , Arun R. Srinivasa

The goal of this paper is to compare several widely used Bayesian model selection methods in practical model selection problems, highlight their differences and give recommendations about the preferred approaches. We focus on the variable…

Methodology · Statistics 2017-12-18 Juho Piironen , Aki Vehtari

In this work, we characterized the material properties of an animal model of the rotator cuff tendon using full volume datasets of both its intact and injured states by capturing internal strain behavior throughout the tendon. Our…

Microstructural models of soft tissue deformation are important in applications including artificial tissue design and surgical planning. The basis of these models, and their advantage over their phenomenological counterparts, is that they…

Biological Physics · Physics 2022-05-06 James Haughton , Simon L. Cotter , William J. Parnell , Tom Shearer

We have developed a frequentist approach for model selection which determines the consistency between any cosmological model and the data using the distribution of likelihoods from the iterative smoothing method. Using this approach, we…

Cosmology and Nongalactic Astrophysics · Physics 2022-03-30 Hanwool Koo , Ryan E. Keeley , Arman Shafieloo , Benjamin L'Huillier

An optimal sequential experimental design approach is developed to computationally characterize soft material properties at the high strain rates associated with bubble cavitation. The approach involves optimal design and model inference.…

Soft Condensed Matter · Physics 2025-11-19 Tianyi Chu , Jonathan B. Estrada , Spencer H. Bryngelson
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