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Clustering is commonly performed as an initial analysis step for uncovering structure in 'omics datasets, e.g. to discover molecular subtypes of disease. The high-throughput, high-dimensional nature of these datasets means that they provide…

Methodology · Statistics 2023-03-02 Paul D. W. Kirk , Filippo Pagani , Sylvia Richardson

One of the possible objectives when designing experiments is to build or formulate a model for predicting future observations. When the primary objective is prediction, some typical approaches in the planning phase are to use…

Methodology · Statistics 2021-10-04 Trent Lemkus , Philip Ramsey , Christopher Gotwalt , Maria Weese

Training deep neural networks usually requires a large amount of labeled data to obtain good performance. However, in medical image analysis, obtaining high-quality labels for the data is laborious and expensive, as accurately annotating…

Computer Vision and Pattern Recognition · Computer Science 2020-05-20 Quande Liu , Lequan Yu , Luyang Luo , Qi Dou , Pheng Ann Heng

Determining early-stage prognostic markers and stratifying patients for effective treatment are two key challenges for improving outcomes for melanoma patients. Previous studies have used tumour transcriptome data to stratify patients into…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Lucy Godson , Navid Alemi , Jeremie Nsengimana , Graham P. Cook , Emily L. Clarke , Darren Treanor , D. Timothy Bishop , Julia Newton-Bishop , Ali Gooya

The data bottleneck has emerged as a fundamental challenge in learning based image restoration methods. Researchers have attempted to generate synthesized training data using paired or unpaired samples to address this challenge. This study…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Dihan Zheng , Yihang Zou , Xiaowen Zhang , Chenglong Bao

This paper investigates the problem of image classification with limited or no annotations, but abundant unlabeled data. The setting exists in many tasks such as semi-supervised image classification, image clustering, and image retrieval.…

Computer Vision and Pattern Recognition · Computer Science 2016-02-05 Dengxin Dai , Luc Van Gool

Unsupervised image classification, or image clustering, aims to group unlabeled images into semantically meaningful categories. Early methods integrated representation learning and clustering within an iterative framework. However, the rise…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Melih Baydar , Emre Akbas

Expectation maximization (EM) algorithm is to find maximum likelihood solution for models having latent variables. A typical example is Gaussian Mixture Model (GMM) which requires Gaussian assumption, however, natural images are highly…

Machine Learning · Computer Science 2018-12-04 Wentian Zhao , Shaojie Wang , Zhihuai Xie , Jing Shi , Chenliang Xu

Traditional transformer-based semantic segmentation relies on quantized embeddings. However, our analysis reveals that autoencoder accuracy on segmentation mask using quantized embeddings (e.g. VQ-VAE) is 8% lower than continuous-valued…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Masud Ahmed , Zahid Hasan , Syed Arefinul Haque , Abu Zaher Md Faridee , Sanjay Purushotham , Suya You , Nirmalya Roy

In this tutorial, we explore Variational Autoencoders (VAEs), an essential framework for unsupervised learning, particularly suited for high-dimensional datasets such as neuroimaging. By integrating deep learning with Bayesian inference,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-15 C. Vázquez-García , F. J. Martínez-Murcia , F. Segovia Román , Juan M. Górriz Sáez

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the progressive accumulation of misfolded proteins, leading to cognitive decline. This study presents a novel stochastic modelling approach to simulate the…

Neurons and Cognition · Quantitative Biology 2024-11-06 Alec MacIver , Hina Shaheen

We present a new instance segmentation approach tailored to biological images, where instances may correspond to individual cells, organisms or plant parts. Unlike instance segmentation for user photographs or road scenes, in biological…

Computer Vision and Pattern Recognition · Computer Science 2020-04-24 Victor Kulikov , Victor Lempitsky

Unsupervised anomaly detection has gained significant attention in the field of medical imaging due to its capability of relieving the costly pixel-level annotation. To achieve this, modern approaches usually utilize generative models to…

Image and Video Processing · Electrical Eng. & Systems 2024-01-22 Rui Xu , Yunke Wang , Bo Du

High-dimensional time series are common in many domains. Since human cognition is not optimized to work well in high-dimensional spaces, these areas could benefit from interpretable low-dimensional representations. However, most…

Machine Learning · Computer Science 2019-01-07 Vincent Fortuin , Matthias Hüser , Francesco Locatello , Heiko Strathmann , Gunnar Rätsch

In machine learning, novelty detection is the task of identifying novel unseen data. During training, only samples from the normal class are available. Test samples are classified as normal or abnormal by assignment of a novelty score. Here…

Analysis of somatic mutation profiles from cancer patients is essential in the development of cancer research. However, the low frequency of most mutations and the varying rates of mutations across patients makes the data extremely…

Weakly supervised image segmentation with image-level labels has drawn attention due to the high cost of pixel-level annotations. Traditional methods using Class Activation Maps (CAMs) often highlight only the most discriminative regions,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Qingchen Tang , Lei Fan , Maurice Pagnucco , Yang Song

Sizing and fitting of Personal Protective Equipment (PPE) is a critical part of the product creation process; however, traditional methods to do this type of work can be labor intensive and based on limited or non-representative…

Machine Learning · Computer Science 2021-05-24 Jacob A. Searcy , Susan L. Sokolowski

The necessity of large amounts of labeled data to train deep models, especially in medical imaging creates an implementation bottleneck in resource-constrained settings. In Insite (labelINg medical imageS usIng submodular funcTions and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Akshat Gautam , Anurag Shandilya , Akshit Srivastava , Venkatapathy Subramanian , Ganesh Ramakrishnan , Kshitij Jadhav

Semi-supervised learning (SSL) for medical image segmentation is a challenging yet highly practical task, which reduces reliance on large-scale labeled dataset by leveraging unlabeled samples. Among SSL techniques, the weak-to-strong…

Computer Vision and Pattern Recognition · Computer Science 2024-10-18 Shiao Xie , Hongyi Wang , Ziwei Niu , Hao Sun , Shuyi Ouyang , Yen-Wei Chen , Lanfen Lin