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We propose a new abstraction set (SynopSet) that has a continuum of visual representations for the explanatory analysis of molecular dynamics simulations (MDS) in the DNA nanotechnology domain. By re-purposing the commonly used progress bar…

Quantitative Methods · Quantitative Biology 2022-05-04 Deng Luo , Alexandre Kouyoumdjian , Ondřej Strnad , Haichao Miao , Ivan Barišić , Ivan Viola

Since its foundations, more than one hundred years ago, the field of structural biology has strived to understand and analyze the properties of molecules and their interactions by studying the structure that they take in 3D space. However,…

Biomolecules · Quantitative Biology 2023-02-27 Gabriele Corso

Visual Molecular Dynamics (VMD) is one of the most widely used molecular graphics software in the community of theoretical simulations. So far, however, it still lacks a graphical user interface (GUI) for molecular manipulations when doing…

Biomolecules · Quantitative Biology 2020-07-03 ChenChen Wu , Shengtang Liu , Shitong Zhang , Zaixing Yang

Machine learning force fields (MLFFs) are gradually evolving towards enabling molecular dynamics simulations of molecules and materials with ab initio accuracy but at a small fraction of the computational cost. However, several challenges…

Morphogenesis is a developmental process in which cells organize into shapes and patterns. Complex, multi-factorial models are commonly used to study morphogenesis. It is difficult to understand the relation between the uncertainty in the…

Cell Behavior · Quantitative Biology 2015-11-25 Sonja E. M. Boas , Maria I. Navarro Jimenez , Roeland M. H. Merks , Joke G. Blom

Creating realistic droplet simulations and animations has long been a formidable challenge for researchers and developers due to the inherent complexity of fluid dynamics. Achieving lifelike droplet splash simulations while managing…

Fluid Dynamics · Physics 2024-11-26 Hossein Keshtkar , Nadine Aburumman

The increasing number of protein-based metamaterials demands reliable and efficient theoretical and computational methods to study the physicochemical properties they may display. In this regard, we develop a simulation strategy based on…

Soft Condensed Matter · Physics 2020-06-23 J. A. Campos Gonzalez Angulo , G. Wiesehan , R. F. Ribeiro , J. Yuen-Zhou

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for a machine learning revolution and have already been profoundly impacted by the…

Chemical Physics · Physics 2019-11-11 Frank Noé , Alexandre Tkatchenko , Klaus-Robert Müller , Cecilia Clementi

In the recent years, scientific workflows gained more and more popularity. In scientific workflows, tasks are typically treated as black boxes. Dealing with their complex interrelations to identify optimization potentials and bottlenecks is…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-13 Ansgar Lößer , Joel Witzke , Florian Schintke , Björn Scheuermann

The Minkowski operators (addition and substraction of sets in vectorial spaces) has been extensively used for Computer Graphics and Image Processing to represent complex shapes. Here we propose to apply those mathematical concepts to extend…

Materials Science · Physics 2013-05-29 Sergio-Andres Galindo-Torres , Fernando Alonso-Marroquin

Numerical simulation of fluids plays an essential role in modeling many physical phenomena, such as weather, climate, aerodynamics and plasma physics. Fluids are well described by the Navier-Stokes equations, but solving these equations at…

Fluid Dynamics · Physics 2022-04-27 Dmitrii Kochkov , Jamie A. Smith , Ayya Alieva , Qing Wang , Michael P. Brenner , Stephan Hoyer

Molecular dynamics (MD) simulations have become popular in materials science, biochemistry, biophysics and several other fields. Improvements in computational resources, in quality of force field parameters and algorithms have yielded…

Soft Condensed Matter · Physics 2016-11-28 Jirasak Wong-ekkabut , Mikko Karttunen

There is more and more evidence that machine learning can be successfully applied in materials science and related fields. However, datasets in these fields are often quite small ($\ll1000$ samples). It makes the most advanced machine…

Computational Physics · Physics 2022-02-25 Guillaume Lambard , Ekaterina Gracheva

Understanding the dynamic behavior of biomolecules is fundamental to elucidating biological function and facilitating drug discovery. While Molecular Dynamics (MD) simulations provide a rigorous physical basis for studying these dynamics,…

Biomolecules · Quantitative Biology 2026-03-19 Liang Shi , Jiarui Lu , Junqi Liu , Chence Shi , Zhi Yang , Jian Tang

The field of structural bioinformatics has seen significant advances with the use of Molecular Dynamics (MD) simulations of biological systems. The MD methodology has allowed to explain and discover molecular mechanisms in a wide range of…

Foundation Models (FM) have increasingly drawn the attention of researchers due to their scalability and generalization across diverse tasks. Inspired by the success of FMs and the principles that have driven advancements in Large Language…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Mohammadreza Baharani , Ghazal Alinezhad Noghre , Armin Danesh Pazho , Gabriel Maldonado , Hamed Tabkhi

Conformations of a single-component bottle-brush polymer with a fully flexible backbone under poor solvent conditions are studied by molecular-dynamics simulations, using a coarse-grained bead-spring model with side chains of up to N=40…

Soft Condensed Matter · Physics 2013-06-25 Nikolaos G. Fytas , Panagiotis E. Theodorakis

Computational Fluid Dynamics (CFD) simulations are a very important tool for many industrial applications, such as aerodynamic optimization of engineering designs like cars shapes, airplanes parts etc. The output of such simulations, in…

Computer Vision and Pattern Recognition · Computer Science 2021-03-12 Theodoros Georgiou , Sebastian Schmitt , Thomas Bäck , Nan Pu , Wei Chen , Michael Lew

Molecular crystal structure prediction represents a grand challenge in computational chemistry due to large sizes of constituent molecules and complex intra- and intermolecular interactions. While generative modeling has revolutionized…

Molecular dynamics (MD) is a powerful technique for studying microscopic phenomena, but its computational cost has driven significant interest in the development of deep learning-based surrogate models. We introduce generative modeling of…

Biomolecules · Quantitative Biology 2024-09-27 Bowen Jing , Hannes Stärk , Tommi Jaakkola , Bonnie Berger