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Objective: Multi-modal functional magnetic resonance imaging (fMRI) can be used to make predictions about individual behavioral and cognitive traits based on brain connectivity networks. Methods: To take advantage of complementary…

Machine Learning · Computer Science 2024-08-27 Gang Qu , Li Xiao , Wenxing Hu , Kun Zhang , Vince D. Calhoun , Yu-Ping Wang

Graph neural network (GNN) models are increasingly being used for the classification of electroencephalography (EEG) data. However, GNN-based diagnosis of neurological disorders, such as Alzheimer's disease (AD), remains a relatively…

Neurons and Cognition · Quantitative Biology 2023-12-21 Dominik Klepl , Fei He , Min Wu , Daniel J. Blackburn , Ptolemaios G. Sarrigiannis

With the arrival of the big data era, more and more data are becoming readily available in various real-world applications and those data are usually highly heterogeneous. Taking computational medicine as an example, we have both Electronic…

Machine Learning · Computer Science 2019-05-08 Xi Sheryl Zhang , Jingyuan Chou , Fei Wang

In this study, we proposed and validated a multi-atlas guided 3D fully convolutional network (FCN) ensemble model (M-FCN) for segmenting brain regions of interest (ROIs) from structural magnetic resonance images (MRIs). One major limitation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-11 Jiong Wu , Xiaoying Tang

Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Yechong Huang , Jiahang Xu , Yuncheng Zhou , Tong Tong , Xiahai Zhuang , the Alzheimer's Disease Neuroimaging Initiative

These days, computational diagnosis strategies of neuropsychiatric disorders are gaining attention day by day. It's critical to determine the brain's functional connectivity based on Functional-Magnetic-Resonance-Imaging(fMRI) to diagnose…

Computer Vision and Pattern Recognition · Computer Science 2022-05-05 Sartaj Ahmed Salman , Zhichao Lian , Marva Saleem , Yuduo Zhang

Functional MRI is a neuroimaging technique that analyzes the functional activity of the brain by measuring blood-oxygen-level-dependent signals throughout the brain. The derived functional features can be used for investigating brain…

Neurons and Cognition · Quantitative Biology 2026-02-16 Giorgio Dolci , Silvia Saglia , Lorenza Brusini , Vince D. Calhoun , Ilaria Boscolo Galazzo , Gloria Menegaz

We propose a mesh-based technique to aid in the classification of Alzheimer's disease dementia (ADD) using mesh representations of the cortex and subcortical structures. Deep learning methods for classification tasks that utilize structural…

Image and Video Processing · Electrical Eng. & Systems 2022-03-14 Emanuel A. Azcona , Pierre Besson , Yunan Wu , Arjun Punjabi , Adam Martersteck , Amil Dravid , Todd B. Parrish , S. Kathleen Bandt , Aggelos K. Katsaggelos

Predicting disease states from functional brain connectivity is critical for the early diagnosis of severe neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease. Existing studies commonly employ Graph Neural…

Machine Learning · Computer Science 2025-04-22 David Yang , Mostafa Abdelmegeed , John Modl , Minjeong Kim

Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing…

Tissues and Organs · Quantitative Biology 2026-04-17 Qianyu Chen , Shujian Yu

Brain networks from functional MRI have advanced our understanding of cortical activity and its disruption in neurodegenerative disorders. Recent work has increasingly focused on dynamic (time-varying) brain networks that capture both…

Neurons and Cognition · Quantitative Biology 2026-04-14 Nicolas Rubido , Venia Batziou , Marwan Fuad , Vesna Vuksanovic

Histopathologic diagnosis relies on simultaneous integration of information from a broad range of scales, ranging from nuclear aberrations ($\approx \mathcal{O}(0.1{\mu m})$) through cellular structures ($\approx \mathcal{O}(10{\mu m})$) to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Rüdiger Schmitz , Frederic Madesta , Maximilian Nielsen , Jenny Krause , René Werner , Thomas Rösch

Alzheimer's disease (AD) is the most prevalent form of dementia. Traditional methods cannot achieve efficient and accurate diagnosis of AD. In this paper, we introduce a novel method based on dynamic functional connectivity (dFC) that can…

Computer Vision and Pattern Recognition · Computer Science 2020-06-25 Xingwei An , Yutao Zhou , Yang Di , Dong Ming

To explain individual differences in development, behavior, and cognition, most previous studies focused on projecting resting-state functional MRI (fMRI) based functional connectivity (FC) data into a low-dimensional space via linear…

Neurons and Cognition · Quantitative Biology 2018-11-01 Li Xiao , Julia M. Stephen , Tony W. Wilson , Vince D. Calhoun , Yu-Ping Wang

We propose a model for diagnosing Autism spectrum disorder (ASD) using multimodal magnetic resonance imaging (MRI) data. Our approach integrates brain connectivity data from diffusion tensor imaging (DTI) and functional MRI (fMRI),…

Neurons and Cognition · Quantitative Biology 2024-10-10 Lu Wei , Yi Huang , Guosheng Yin , Fode Zhang , Manxue Zhang , Bin Liu

Resting-state functional MRI (rs-fMRI) scans hold the potential to serve as a diagnostic or prognostic tool for a wide variety of conditions, such as autism, Alzheimer's disease, and stroke. While a growing number of studies have…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert Sabuncu

This paper presents a comprehensive and quality collection of functional human brain network data for potential research in the intersection of neuroscience, machine learning, and graph analytics. Anatomical and functional MRI images have…

Clinical studies reveal disruptions in brain structural connectivity (SC) and functional connectivity (FC) in neuropsychiatric disorders such as schizophrenia (SZ). Traditional approaches might rely solely on SC due to limited functional…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Badhan Mazumder , Ayush Kanyal , Lei Wu , Vince D. Calhoun , Dong Hye Ye

Brain networks has attracted the interests of many neuroscientists. From functional MRI (fMRI) data, statistical tools have been developed to recover brain networks. However, the dimensionality of whole-brain fMRI, usually in hundreds of…

Methodology · Statistics 2014-04-08 Xi Luo

The accurate diagnosis of Alzheimer's disease (AD) and prognosis of mild cognitive impairment (MCI) conversion are crucial for early intervention. However, existing multimodal methods face several challenges, from the heterogeneity of input…

Machine Learning · Computer Science 2025-03-20 Chenyu Liu , Luca Rossi