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Microscopic biological systems operate far from equilibrium, are subject to strong fluctuations, and are composed of many coupled components with interactions varying in nature and strength. Researchers are actively investigating the…

Statistical Mechanics · Physics 2023-12-25 Emma Lathouwers , David A. Sivak

We propose a decomposition of information flow into housekeeping and excess components for autonomous bipartite systems described by Markov jump processes. We introduce this decomposition using the geometric structure of probability…

Statistical Mechanics · Physics 2026-05-08 Yoh Maekawa , Ryuna Nagayama , Kohei Yoshimura , Sosuke Ito

Molecular machines transduce free energy between different forms throughout all living organisms. While truly machines in their own right, unlike their macroscopic counterparts molecular machines are characterized by stochastic…

Statistical Mechanics · Physics 2025-06-13 Matthew P. Leighton , David A. Sivak

Molecular motors fulfill critical functions within all living beings. Understanding their underlying working principles is therefore of great interest. Here we develop a simple model inspired by the two-component biomolecular motor Fo-F1…

Statistical Mechanics · Physics 2024-12-30 Mathis Grelier , David A. Sivak , Jannik Ehrich

The framework of bipartite stochastic thermodynamics is a powerful tool to analyze a composite system's internal thermodynamics. It has been used to study the components of different molecular machines such as ATP synthase. However, this…

Statistical Mechanics · Physics 2026-04-15 Julian D. Jiménez-Paz , Matthew P. Leighton , David A. Sivak

We provide a unified thermodynamic formalism describing information transfers in autonomous as well as nonautonomous systems described by stochastic thermodynamics. We demonstrate how information is continuously generated in an auxiliary…

Statistical Mechanics · Physics 2014-08-06 Jordan M. Horowitz , Massimiliano Esposito

The second law of thermodynamics dictates the fundamental limits to the amount of energy and information that can be exchanged between physical systems. In this work, we extend a thermodynamic formalism describing this flow of energy and…

Statistical Mechanics · Physics 2015-03-24 Jordan M. Horowitz

Information thermodynamics relates the rate of change of mutual information between two interacting subsystems to their thermodynamics when the joined system is described by a bipartite stochastic dynamics satisfying local detailed balance.…

Statistical Mechanics · Physics 2022-08-05 Emanuele Penocchio , Francesco Avanzini , Massimiliano Esposito

Information dynamics is an emerging description of information processing in complex systems which describes systems in terms of intrinsic computation, identifying computational primitives of information storage and transfer. In this paper…

Statistical Mechanics · Physics 2018-10-03 Richard E. Spinney , Joseph T. Lizier , Mikhail Prokopenko

Using information theory we derive a thermodynamics for systems evolving under a collective motion, i.e. under a time-odd constraint. An illustration within the Lattice gas Model is given for two model cases: a collision between two complex…

Nuclear Theory · Physics 2015-06-26 F. Gulminelli , PH. Chomaz

Biological molecular machines are bifunctional enzymes that catalyze two processes: one donating free energy and the other accepting it. Recent studies show that most protein enzymes have rich stochastic dynamics of transitions between the…

Biological Physics · Physics 2023-02-02 Michal Kurzynski , Przemyslaw Chelminiak

We report two results complementing the second law of thermodynamics for Markovian open quantum systems coupled to multiple reservoirs with different temperatures and chemical potentials. First, we derive a nonequilibrium free energy…

Statistical Mechanics · Physics 2019-04-18 Krzysztof Ptaszynski , Massimiliano Esposito

Fluctuations in biochemical networks, e.g., in a living cell, have a complex origin that precludes a description of such systems in terms of bipartite or multipartite processes, as is usually done in the framework of stochastic and/or…

Statistical Mechanics · Physics 2020-01-29 R. Chétrite , M. L. Rosinberg , T. Sagawa , G. Tarjus

Molecular machines composed of coupled subsystems transduce free energy between different external reservoirs, in the process internally transducing energy and information. While subsystem efficiencies of these molecular machines have been…

Statistical Mechanics · Physics 2023-05-23 Matthew P. Leighton , David A. Sivak

Quantum information engines leverage information as a thermodynamic resource to facilitate energy conversion. In the operation of such engines, the information flow between the working substance and the controller is pivotal, however,…

Statistical Mechanics · Physics 2026-05-26 Hao Feng , Junjie Liu

We extend the principles of information thermodynamics to study energy and information exchanges between coupled systems composed of one part undergoing a Markov jump process and another underdamped diffusion. We derive integral fluctuation…

Statistical Mechanics · Physics 2024-12-05 Ashwin Gopal , Nahuel Freitas , Massimiliano Esposito

We explore the dynamics of information systems. We show that the driving force for information dynamics is determined by both the information landscape and information flux which determines the equilibrium time reversible and the…

Statistical Mechanics · Physics 2018-02-14 Qian Zeng , Jin Wang

Biological molecular machines are enzymes that simultaneously catalyze two processes, one donating free energy and second accepting it. Recent studies show that most native protein enzymes have a rich stochastic dynamics that often…

Biological Physics · Physics 2018-12-21 Michal Kurzynski , Przemyslaw Chelminiak

The thermodynamic uncertainty relation quantifies a trade-off between the relative fluctuations of trajectory currents and the thermodynamic cost, indicating that the current precision is fundamentally constrained by entropy production. In…

Quantum Physics · Physics 2026-03-16 Ryotaro Honma , Tan Van Vu

Quantifying the flow of energy within and through fluctuating nanoscale systems poses a significant challenge to understanding microscopic biological machines. A common approach involves coarse-graining, which allows a simplified…

Statistical Mechanics · Physics 2021-03-12 Steven J Large , David A Sivak
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