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Cancers follow a clonal Darwinian evolution, with fitter subclones replacing more quiescent cells, ultimately giving rise to macroscopic disease. High-throughput genomics provides the opportunity to investigate these processes and determine…

Quantitative Methods · Quantitative Biology 2014-10-07 Sakellarios Zairis , Hossein Khiabanian , Andrew J. Blumberg , Raul Rabadan

Despite the popularity of explainable AI, there is limited work on effective methods for unsupervised learning. We study algorithms for $k$-means clustering, focusing on a trade-off between explainability and accuracy. Following prior work,…

Machine Learning · Computer Science 2020-07-03 Nave Frost , Michal Moshkovitz , Cyrus Rashtchian

The amount of completely sequenced chloroplast genomes increases rapidly every day, leading to the possibility to build large-scale phylogenetic trees of plant species. Considering a subset of close plant species defined according to their…

Artificial Intelligence · Computer Science 2016-09-01 Bassam AlKindy , Bashar Al-Nuaimi , Christophe Guyeux , Jean-François Couchot , Michel Salomon , Reem Alsrraj , Laurent Philippe

Phylogenetic inference is an intractable statistical problem on a complex space. Markov chain Monte Carlo methods are the primary tool for Bayesian phylogenetic inference but it is challenging to construct efficient schemes to explore the…

Methodology · Statistics 2022-10-11 Luke J. Kelly , Robin J. Ryder , Grégoire Clarté

Many discrete mathematics problems in phylogenetics are defined in terms of the relative labeling of pairs of leaf-labeled trees. These relative labelings are naturally formalized as tanglegrams, which have previously been an object of…

Populations and Evolution · Quantitative Biology 2015-07-20 Frederick A Matsen , Sara Billey , Arnold Kas , Matjaž Konvalinka

Phylogenetic tree inference using deep DNA sequencing is reshaping our understanding of rapidly evolving systems, such as the within-host battle between viruses and the immune system. Densely sampled phylogenetic trees can contain special…

Populations and Evolution · Quantitative Biology 2020-06-03 Cheng Zhang , Vu Dinh , Frederick A. Matsen

Segmentation of a colour image composed of different kinds of texture regions can be a hard problem, namely to compute for an exact texture fields and a decision of the optimum number of segmentation areas in an image when it contains…

Artificial Intelligence · Computer Science 2007-05-23 Vitorino Ramos , Fernando Muge

Classification of gene trees is an important task both in the analysis of multi-locus phylogenetic data, and assessment of the convergence of Markov Chain Monte Carlo (MCMC) analyses used in Bayesian phylogenetic tree reconstruction. The…

Combinatorics · Mathematics 2024-06-10 Georgios Aliatimis , Ruriko Yoshida , Burak Boyaci , James A. Grant

Rooted phylogenetic networks are often used to represent conflicting phylogenetic signals. Given a set of clusters, a network is said to represent these clusters in the "softwired" sense if, for each cluster in the input set, at least one…

Populations and Evolution · Quantitative Biology 2011-03-10 Steven Kelk , Celine Scornavacca , Leo van Iersel

Phylogenetic networks are used to represent the evolutionary history of species. They are versatile when compared to traditional phylogenetic trees, as they capture more complex evolutionary events such as hybridization and horizontal gene…

Combinatorics · Mathematics 2023-05-18 Shunsuke Maeda , Yusuke Kaneko , Hideaki Muramatsu , Yukihiro Murakami , Momoko Hayamizu

We compare the phylogenetic tensors for various trees and networks for two, three and four taxa. If the probability spaces between one tree or network and another are not identical then there will be phylogenetic tensors that could have…

Populations and Evolution · Quantitative Biology 2016-06-24 Jonathan Mitchell

In social network analysis, the size of the k-core, i.e., the maximal induced subgraph of the network with minimum degree at least k, is frequently adopted as a typical metric to evaluate the cohesiveness of a community. We address the…

Optimization and Control · Mathematics 2023-05-03 Martina Cerulli , Domenico Serra , Carmine Sorgente , Claudia Archetti , Ivana Ljubic

Most of major algorithms for phylogenetic tree reconstruction assume that sequences in the analyzed set either do not have any offspring, or that parent sequences can maximally mutate into just two descendants. The graph resulting from such…

Populations and Evolution · Quantitative Biology 2013-10-09 Piotr Plonski , Jan P. Radomski

It is generally accepted that "diversity" is associated with success in evolutionary algorithms. However, diversity is a broad concept that can be measured and defined in a multitude of ways. To date, most evolutionary computation research…

Neural and Evolutionary Computing · Computer Science 2023-01-18 Jose Guadalupe Hernandez , Alexander Lalejini , Emily Dolson

In an era where artificial intelligence and machine learning algorithms increasingly impact human life, it is crucial to develop models that account for potential discrimination in their predictions. This paper tackles this problem by…

Machine Learning · Statistics 2024-10-10 Anna Gottard , Vanessa Verrina , Sabrina Giordano

K-means is one of the most widely used clustering algorithms in various disciplines, especially for large datasets. However the method is known to be highly sensitive to initial seed selection of cluster centers. K-means++ has been proposed…

Machine Learning · Computer Science 2016-04-19 Fouad Khan

We consider the probability that a spanning tree chosen uniformly at random from a graph can be partitioned into a fixed number $k$ of trees of equal size by removing $k-1$ edges. In that case, the spanning tree is called {\em splittable}.…

Data Structures and Algorithms · Computer Science 2026-02-25 David Gillman , Jacob Platnick , Dana Randall

The adoption of the distributed paradigm has allowed applications to increase their scalability, robustness and fault tolerance, but it has also complicated their structure, leading to an exponential growth of the applications'…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-05-23 Ioannis Giannakopoulos , Dimitrios Tsoumakos , Nectarios Koziris

The marginal likelihood of a model is a key quantity for assessing the evidence provided by the data in support of a model. The marginal likelihood is the normalizing constant for the posterior density, obtained by integrating the product…

Populations and Evolution · Quantitative Biology 2018-11-30 Mathieu Fourment , Andrew F. Magee , Chris Whidden , Arman Bilge , Frederick A. Matsen , Vladimir N. Minin

The study of Markov processes and broadcasting on trees has deep connections to a variety of areas including statistical physics, graphical models, phylogenetic reconstruction, Markov Chain Monte Carlo, and community detection in random…

Probability · Mathematics 2022-10-26 Frederic Koehler , Elchanan Mossel
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