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Clinical notes contain an extensive record of a patient's health status, such as smoking status or the presence of heart conditions. However, this detail is not replicated within the structured data of electronic health systems.…

Computation and Language · Computer Science 2020-09-18 Andriy Mulyar , Elliot Schumacher , Masoud Rouhizadeh , Mark Dredze

Identifying patient cohorts from clinical notes in secondary electronic health records is a fundamental task in clinical information management. However, with the growing number of clinical notes, it becomes challenging to analyze the data…

Computation and Language · Computer Science 2023-03-14 Sahar Khalafi , Nasser Ghadiri , Milad Moradi

Clustering time-series data in healthcare is crucial for clinical phenotyping to understand patients' disease progression patterns and to design treatment guidelines tailored to homogeneous patient subgroups. While rich temporal dynamics…

Machine Learning · Computer Science 2023-02-27 Yuchao Qin , Mihaela van der Schaar , Changhee Lee

Objective: To develop an effective and scalable individual-level patient cost prediction method by automatically learning hidden temporal patterns from multivariate time series data in patient insurance claims using a convolutional neural…

Machine Learning · Computer Science 2020-09-16 Mohammad Amin Morid , Olivia R. Liu Sheng , Kensaku Kawamoto , Samir Abdelrahman

Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently for patient phenotyping. Patient phenotyping is a classification task for determining whether a patient has a medical…

The increased availability of electronic health records (EHRs) have spearheaded the initiative for precision medicine using data driven approaches. Essential to this effort is the ability to identify patients with certain medical conditions…

The paper presents a systematic review of state-of-the-art approaches to identify patient cohorts using electronic health records. It gives a comprehensive overview of the most commonly de-tected phenotypes and its underlying data sets.…

Machine Learning · Statistics 2017-07-25 Norman Hiob , Stefan Lessmann

Cohort studies are of significant importance in the field of healthcare analysis. However, existing methods typically involve manual, labor-intensive, and expert-driven pattern definitions or rely on simplistic clustering techniques that…

Machine Learning · Computer Science 2024-06-21 Qingpeng Cai , Kaiping Zheng , H. V. Jagadish , Beng Chin Ooi , James Yip

Identifying a patient's key problems over time is a common task for providers at the point care, yet a complex and time-consuming activity given current electric health records. To enable a problem-oriented summarizer to identify a…

Applications · Statistics 2020-03-26 Gal Levy-Fix , Jason Zucker , Konstantin Stojanovic , Noémie Elhadad

Phenotyping is the process of distinguishing groups of patients to identify different types of disease progression. A recent trend employs low-rank matrix and tensor factorization methods for their capability of dealing with multi-modal,…

Machine Learning · Computer Science 2025-06-26 Cristian Minoccheri , Sophia Tesic , Kayvan Najarian , Ryan Stidham

In epidemiological and clinical studies, identifying patients' phenotypes based on longitudinal profiles is critical to understanding the disease's developmental patterns. The current study was motivated by data from a Canadian birth cohort…

Methodology · Statistics 2023-03-22 Zhiwen Tan , Chang Shen , Padmaja Subbarao , Wendy Lou , Zihang Lu

Computational Phenotype Discovery research has taken various pragmatic approaches to disentangling phenotypes from the episodic observations in Electronic Health Records. In this work, we use transformation into continuous, longitudinal…

Applications · Statistics 2019-07-26 Thomas A. Lasko , Diego A. Mesa

We hypothesize that large language models (LLMs) based on the transformer architecture can enable automated detection of clinical phenotype terms, including terms not documented in the HPO. In this study, we developed two types of models:…

Quantitative Methods · Quantitative Biology 2023-11-10 Jingye Yang , Cong Liu , Wendy Deng , Da Wu , Chunhua Weng , Yunyun Zhou , Kai Wang

Community detection in multilayer networks, which aims to identify groups of nodes exhibiting similar connectivity patterns across multiple network layers, has attracted considerable attention in recent years. Most existing methods are…

Methodology · Statistics 2026-01-26 Dapeng Shi , Haoran Zhang , Tiandong Wang , Junhui Wang

Mining electronic health records for patients who satisfy a set of predefined criteria is known in medical informatics as phenotyping. Phenotyping has numerous applications such as outcome prediction, clinical trial recruitment, and…

Computation and Language · Computer Science 2018-05-08 Dmitriy Dligach , Timothy Miller

Models have been proposed to extract temporal patterns from longitudinal electronic health records (EHR) for clinical predictive models. However, the common relations among patients (e.g., receiving the same medical treatments) were rarely…

Applications · Statistics 2019-09-27 Yue Wang , Tong Wu , Yunlong Wang , Gao Wang

Traditionally, machine learning algorithms rely on the assumption that all features of a given dataset are available for free. However, there are many concerns such as monetary data collection costs, patient discomfort in medical…

Machine Learning · Computer Science 2019-07-02 Mohammad Kachuee , Kimmo Karkkainen , Orpaz Goldstein , Davina Zamanzadeh , Majid Sarrafzadeh

Phenotypic characterization is essential for understanding heterogeneity in chronic diseases and for guiding personalized interventions. Long COVID, a complex and persistent condition, yet its clinical subphenotypes remain poorly…

Machine Learning · Computer Science 2026-03-20 Jing Wang , Jie Shen , Amar Sra , Qiaomin Xie , Jeremy C Weiss

It has been recently shown that sparse, nonnegative tensor factorization of multi-modal electronic health record data is a promising approach to high-throughput computational phenotyping. However, such approaches typically do not leverage…

Machine Learning · Computer Science 2018-08-09 Jette Henderson , Bradley A. Malin , Joyce C. Ho , Joydeep Ghosh

Depression is a major global public health challenge and its early identification is crucial. Social media data provides a new perspective for depression detection, but existing methods face limitations such as insufficient accuracy,…

Artificial Intelligence · Computer Science 2026-01-12 Yukun Yang
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