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Dynamic positron emission tomography (PET) images can reveal the distribution of tracers in the organism and the dynamic processes involved in biochemical reactions, and it is widely used in clinical practice. Despite the high effectiveness…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Jie Sun , Junyan Zhang , Qian Xia , Chuanfu Sun , Yumei Chen , Yunjie Yang , Huafeng Liu , Wentao Zhu , Qiegen Liu

Patient-specific hemodynamics assessment could support diagnosis and treatment of neurovascular diseases. Currently, conventional medical imaging modalities are not able to accurately acquire high-resolution hemodynamic information that…

As a necessary process in drug development, finding a drug compound that can selectively bind to a specific protein is highly challenging and costly. Drug-target affinity (DTA), which represents the strength of drug-target interaction…

Biomolecules · Quantitative Biology 2023-12-18 Zhiqin Zhu , Zheng Yao , Guanqiu Qi , Neal Mazur , Baisen Cong

Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…

Medical Physics · Physics 2023-12-05 Keshav Kumar K. , NVSL Narasimham , A. Ramakrishna Prasad

We present an integral-based technique (IBT) algorithm to accelerate supernova (SN) radiative transfer calculations. The algorithm utilizes ``integral packets'', which are calculated by the path integral of the Monte-Carlo energy packets,…

High Energy Astrophysical Phenomena · Physics 2024-09-13 Xingzhuo Chen , Lifan Wang , Daniel Kasen

Due to the inter- and intra- variation of respiratory motion, it is highly desired to provide real-time volumetric images during the treatment delivery of lung stereotactic body radiation therapy (SBRT) for accurate and active motion…

This paper explores the use of deep learning-based computer vision for real-time monitoring of the flow in intravenous (IV) infusions. IV infusions are among the most common therapies in hospitalized patients and, given that both…

Computer Vision and Pattern Recognition · Computer Science 2020-11-24 Nicola Giaquinto , Marco Scarpetta , Maurizio Spadavecchia , Gregorio Andria

Purpose: To develop a novel aperture-based algorithm for volumetric modulated arc therapy (VMAT) treatment plan optimization with high quality and high efficiency. Methods: The VMAT optimization problem is formulated as a large-scale convex…

Medical Physics · Physics 2015-05-19 Chunhua Men , H. Edwin Romeijn , Xun Jia , Steve B. Jiang

It is possible to find the optimized radiation dose per session for a radiotherapy (RT) treatment, using a population dynamics model. This has already been done in a previous work for a protocol with 30 sessions and a fixed dose per…

The most advanced text-to-image (T2I) models require significant training costs (e.g., millions of GPU hours), seriously hindering the fundamental innovation for the AIGC community while increasing CO2 emissions. This paper introduces…

Computer Vision and Pattern Recognition · Computer Science 2024-01-01 Junsong Chen , Jincheng Yu , Chongjian Ge , Lewei Yao , Enze Xie , Yue Wu , Zhongdao Wang , James Kwok , Ping Luo , Huchuan Lu , Zhenguo Li

We propose an oAPT workflow that incorporates all these functionalities and validate its clinical implementation feasibility with prostate patients. AI-based auto-segmentation tool AccuContourTM (Manteia, Xiamen, China) was seamlessly…

Deep neural networks based on unrolled iterative algorithms have achieved remarkable success in sparse reconstruction applications, such as synthetic aperture radar (SAR) tomographic inversion (TomoSAR). However, the currently available…

Signal Processing · Electrical Eng. & Systems 2026-04-22 Kun Qian , Yuanyuan Wang , Peter Jung , Yilei Shi , Xiao Xiang Zhu

In this paper knowledge based planning has been revolutionized via a novel mathematical model which converts three dimensional dose distribution (3D3) prediction to a clinical utilizable IMRT treatment plan. Presented model has benefited…

Optimization and Control · Mathematics 2022-06-14 Ali Yousefi , Saeedeh Ketabi , Iraj Abedi

The estimation of direction of arrival (DOA) is a crucial issue in conventional radar, wireless communication, and integrated sensing and communication (ISAC) systems. However, low-cost systems often suffer from imperfect factors, such as…

Signal Processing · Electrical Eng. & Systems 2024-03-21 Peng Chen , Zhimin Chen , Liang Liu , Yun Chen , Xianbin Wang

Prostate radiotherapy is a well established curative oncology modality, which in future will use Magnetic Resonance Imaging (MRI)-based radiotherapy for daily adaptive radiotherapy target definition. However the time needed to delineate the…

Image and Video Processing · Electrical Eng. & Systems 2020-11-17 David Gillespie , Connah Kendrick , Ian Boon , Cheng Boon , Tim Rattay , Moi Hoon Yap

Positron emission tomography (PET) is widely used in various clinical applications, including cancer diagnosis, heart disease and neuro disorders. The use of radioactive tracer in PET imaging raises concerns due to the risk of radiation…

Computer Vision and Pattern Recognition · Computer Science 2017-12-13 Junshen Xu , Enhao Gong , John Pauly , Greg Zaharchuk

PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors.…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Ran Hong , Yuxia Huang , Lei Liu , Zhonghui Wu , Bingxuan Li , Xuemei Wang , Qiegen Liu

Delineation of tumors and organs-at-risk permits detecting and correcting changes in the patients' anatomy throughout the treatment, making it a core step of adaptive proton therapy (APT). Although AI-based auto-contouring technologies have…

Due to the increasing complexity of radiotherapy delivery, accurate dose verification has become an essential part of the clinical treatment process. The purpose of this work was to develop an electronic portal image (EPI) based…

Medical Physics · Physics 2015-06-17 Reid W Townson , Sergei Zavgorodni

Automating the radiotherapy treatment planning process is a technically challenging problem. The majority of automated approaches have focused on customizing and inferring dose volume objectives to used in plan optimization. In this work we…

Medical Physics · Physics 2017-01-04 Chris McIntosh , Thomas G. Purdie