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Photoacoustic (PA) imaging systems based on clinical linear ultrasound arrays have become increasingly popular in translational PA research. Such systems can be more easily integrated in a clinical workflow due to the simultaneous access to…

Photoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo. However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely…

Medical Physics · Physics 2019-12-17 Marcel Gehrung , Sarah Bohndiek , Joanna Brunker

Contrast-enhanced computed tomography (CECT) is pivotal for highlighting tissue perfusion and vascularity, yet its clinical ubiquity is impeded by the invasive nature of contrast agents and radiation risks. While virtual contrast…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Zilong Li , Dongyang Li , Chenglong Ma , Zhan Feng , Dakai Jin , Junping Zhang , Hao Luo , Fan Wang , Hongming Shan

Optical Coherence Tomography (OCT) was originally conceived as a volumetric imaging method. Quickly, OCT images went beyond structural data and started to provide functional information about an object enabling for example visualization of…

Four-dimensional (4D) Flow MRI can noninvasively measure cerebrovascular hemodynamics but remains underused clinically because current workflows rely on manual vessel segmentation and yield velocity fields sensitive to noise, artifacts, and…

Image and Video Processing · Electrical Eng. & Systems 2026-01-21 Abhishek Singh , Vitaliy L. Rayz , Pavlos P. Vlachos

Quantitative photoacoustic computed tomography (qPACT) is a promising imaging modality for estimating physiological parameters such as blood oxygen saturation. However, developing robust qPACT reconstruction methods remains challenging due…

Medical Physics · Physics 2025-10-07 Refik Mert Cam , Seonyeong Park , Umberto Villa , Mark A. Anastasio

Despite significant advances in artificial intelligence (AI) for computer vision, its application in medical imaging has been limited by the burden and limits of expert-generated labels. We used images from optical coherence tomography…

Computer Vision and Pattern Recognition · Computer Science 2018-02-27 Cecilia S. Lee , Ariel J. Tyring , Yue Wu , Sa Xiao , Ariel S. Rokem , Nicolaas P. Deruyter , Qinqin Zhang , Adnan Tufail , Ruikang K. Wang , Aaron Y. Lee

Billions of vascular access procedures are performed annually worldwide, serving as a crucial first step in various clinical diagnostic and therapeutic procedures. For pediatric or elderly individuals, whose vessels are small in size…

Robotics · Computer Science 2025-04-09 Shuaiqi Jing , Tianliang Yao , Ke Zhang , Di Wu , Qiulin Wang , Zixi Chen , Ke Chen , Peng Qi

Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. While photoacoustic (PA)…

Medical Physics · Physics 2018-08-15 Thomas Kirchner , Janek Gröhl , Lena Maier-Hein

A comprehensive assessment of retinal health demands reliable and precise methods to measure localized blood perfusion. Despite considerable advancements in imaging techniques, such as indocyanine green and fluorescein angiography, along…

Medical Physics · Physics 2024-03-15 Michael Atlan

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. If the object…

Medical Physics · Physics 2017-09-08 Joemini Poudel , Thomas P. Matthews , Lei Li , Mark A. Anastasio , Lihong V. Wang

Optical coherence tomography (OCT) and photoacoustic tomography (PAT) are emerging non-invasive biological and medical imaging techniques. It is a recent trend in experimental science to design experiments that perform PAT and OCT imaging…

Analysis of PDEs · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

Intracoronary Optical Coherence Tomography (OCT) enables high-resolution visualization of coronary vessel anatomy but presents challenges due to noise, imaging artifacts, and complex tissue structures. This paper proposes a fully automated…

Computer Vision and Pattern Recognition · Computer Science 2026-02-20 Amal Lahchim , Lambros Athanasiou

The segmentation and analysis of coronary arteries from intravascular optical coherence tomography (IVOCT) is an important aspect of diagnosing and managing coronary artery disease. Current image processing methods are hindered by the time…

Machine Learning · Computer Science 2021-04-20 Arjun Balaji , Lachlan Kelsey , Kamran Majeed , Carl Schultz , Barry Doyle

Ultrasound vascular imaging is limited by acoustic diffraction, restricting visualization of microvessels essential for understanding organ function and disease. Label-free super-resolution methods exploiting endogenous red blood cells have…

Photoacoustic imaging (PAI) is a non-invasive imaging modality that detects the ultrasound signal generated from tissue with light excitation. Photoacoustic computed tomography (PACT) uses unfocused large-area light to illuminate the target…

Image and Video Processing · Electrical Eng. & Systems 2022-04-13 Hengrong Lan , Jiali Gong , Fei Gao

Optical Coherence Tomography Angiography (OCTA) has been increasingly used in the management of eye and systemic diseases in recent years. Manual or automatic analysis of blood vessel in 2D OCTA images (en face angiograms) is commonly used…

Image and Video Processing · Electrical Eng. & Systems 2021-03-01 Shuai Yu , Jianyang Xie , Jinkui Hao , Yalin Zheng , Jiong Zhang , Yan Hu , Jiang Liu , Yitian Zhao

Photoacoustic tomography (PAT) and thermoacoustic tomography (TAT) both leverage acoustic signals generated by electromagnetic absorption to noninvasively image deep tissues. PAT operates by detecting optical absorption, whereas TAT targets…

Optics · Physics 2026-03-09 Skyler P. Selvin , XuanHao Wang , Handi Deng , Bohua Chen , Cheng Ma

In this paper, we propose the use of Optical Coherence Tomography (OCT) imaging for the problem of iris presentation attack (PA) detection. We assess its viability by comparing its performance with respect to traditional iris imaging…

Computer Vision and Pattern Recognition · Computer Science 2020-11-24 Renu Sharma , Arun Ross

In many clinical conditions, such as head trauma, stroke, and low cardiac output states, the brain is at risk for hypoxic-ischemic injury. The metabolic rate and oxygen consumption of the brain are reflected in internal jugular venous…