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Optical imaging of blood flow yields critical functional insights into the circulatory system, but its clinical implementation has typically been limited to shallow depths (~1 millimeter) due to light scattering in biological tissue. Here,…
Photoacoustic computed tomography (PACT) is a proven technology for imaging hemodynamics in deep brain of small animal models. PACT is inherently compatible with ultrasound (US) imaging, providing complementary contrast mechanisms. While…
Photoacoustic tomography is a contrast agent-free imaging technique capable of visualizing blood vessels and tumor-associated vascularization in breast tissue. While sophisticated breast imaging systems have been recently developed, there…
Photoacoustic computed tomography (PACT) is a hybrid imaging modality, which combines the high optical contrast of pure optical imaging and the high penetration depth of ultrasound imaging. However, photoacoustic image dataset with good…
Photoacoustic tomography (PAT) offers high optical contrast with acoustic imaging depth, making it essential for biomedical applications. While many all-optical systems have been developed to address limitations of ultrasound transducers,…
Optical coherence tomography angiography (OCTA) is a novel noninvasive imaging modality for visualization of retinal blood flow in the human retina. Using specific OCTA imaging biomarkers for the identification of pathologies, automated…
Photoacoustic (PA) imaging combines the high optical absorption contrast of optical imaging with the deep tissue penetration of ultrasound detection, offering great potential for functional imaging and disease diagnosis. However, current PA…
We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager…
Spherical matrix arrays arguably represent an advantageous tomographic detection geometry for non-invasive deep tissue mapping of vascular networks and oxygenation with volumetric optoacoustic tomography (VOT). Hybridization of VOT with…
Photoacoustic tomography (PAT) is a rapidly-evolving medical imaging modality that combines optical absorption contrast with ultrasound imaging depth. One challenge in PAT is image reconstruction with inadequate acoustic signals due to…
Structural microvascular alterations and dysfunction serve as key disease indicators of cancer, diabetes, ischemic stroke, neurodegenerative disorders and many other conditions. In vivo visualization of the microvasculature has…
Limited-view artefacts are commonly present in optoacoustic tomography images, mainly due to practical geometrical and physical constraints imposed by the imaging systems as well as limited light penetration into large optically opaque…
Photoacoustic imaging (PAI) represents an innovative biomedical imaging modality that harnesses the advantages of optical resolution and acoustic penetration depth while ensuring enhanced safety. Despite its promising potential across a…
Photoacoustic tomography leverages ultrasound's deep tissue penetration to retrieve optical absorption contrast well beyond the optical diffusion limit. Conventional photoacoustic systems rely on externally delivered light and are therefore…
Photoacoustic (PA) imaging systems are spreading in the biomedical community, and the de-velopment of new PA contrast agents is an active area of research. However, PA contrast agents are usually characterized with spectrophotometry or…
Automated blood vessel segmentation is vital for biomedical imaging, as vessel changes indicate many pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical variations across patients,…
Photoacoustic tomography (PAT) is a nonionizing imaging modality capable of acquiring high contrast and resolution images of optical absorption at depths greater than traditional optical imaging techniques. Practical considerations with…
The resolution of photoacoustic imaging deep inside scattering media is limited by the acoustic diffraction limit. In this work, taking inspiration from super-resolution imaging techniques developed to beat the optical diffraction limit, we…
An optical imaging system is proposed for quantitatively assessing jugular venous response to altered central venous pressure. The proposed system assesses sub-surface optical absorption changes from jugular venous waveforms with a spatial…
Photoacoustic(PA) imaging is a non-destructive and non-invasive technology for visualizing minute blood vessel structures in the body using ultrasonic sensors. In PA imaging, the image quality of a single-shot image is poor, and it is…