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The transport and manipulation of particles and cells in microfluidic devices has become a core methodology in domains ranging from molecular biology to manufacturing and drug design. The rational design and operation of such devices can…

Computational Engineering, Finance, and Science · Computer Science 2020-07-15 Dmitry Alexeev , Lucas Amoudruz , Sergey Litvinov , Petros Koumoutsakos

Learning to Optimize (L2O) enhances optimization efficiency with integrated neural networks. L2O paradigms achieve great outcomes, e.g., refitting optimizer, generating unseen solutions iteratively or directly. However, conventional L2O…

Machine Learning · Computer Science 2025-03-17 Mingjia Shi , Ruihan Lin , Xuxi Chen , Yuhao Zhou , Zezhen Ding , Pingzhi Li , Tong Wang , Kai Wang , Zhangyang Wang , Jiheng Zhang , Tianlong Chen

Transistor topology optimization is a critical step in standard cell design, directly dictating diffusion sharing efficiency and downstream routability. However, identifying optimal topologies remains a persistent bottleneck, as…

Machine Learning · Computer Science 2026-04-17 Zhan Song , Yu-Tung Liu , Chen Chen , Guoheng Sun , Jiaqi Yin , Chia-tung Ho , Ang Li , Haoxing Ren , Cunxi Yu

Power system operators are increasingly deploying Grid Enhancing Technologies (GETs) to mitigate operational challenges such as line and transformer congestion, and voltage violations. These technologies, including Network Topology…

Systems and Control · Electrical Eng. & Systems 2026-02-24 Junseon Park , Hyeongon Park , Rahul K. Gupta

Many crucial scientific problems involve designing novel molecules with desired properties, which can be formulated as a black-box optimization problem over the discrete chemical space. In practice, multiple conflicting objectives and…

Machine Learning · Computer Science 2023-11-03 Yiheng Zhu , Jialu Wu , Chaowen Hu , Jiahuan Yan , Chang-Yu Hsieh , Tingjun Hou , Jian Wu

Data flow analysis and optimization is considered for homogeneous rectangular mesh networks. We propose a flow matrix equation which allows a closed-form characterization of the nature of the minimal time solution, speedup and a simple…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-12-30 Junwei Zhang , Yang Liu , Li Shi , Thomas G. Robertazzi

Topology optimization by optimally distributing materials in a given domain requires non-gradient optimizers to solve highly complicated problems. However, with hundreds of design variables or more involved, solving such problems would…

Computational Engineering, Finance, and Science · Computer Science 2022-01-27 Changyu Deng , Yizhou Wang , Can Qin , Yun Fu , Wei Lu

This paper firstly presents an implementation of multi-material topology optimization (MTO) for in-plane bi-directional functionally graded (IBFG) non-uniform thickness Reissner-Mindlin plates. The mathematical formulation of the MTO is…

Numerical Analysis · Mathematics 2023-09-29 Nam G. Luu , Thanh T. Banh

A new topology optimization method called the Proportional Topology Optimization (PTO) is presented. As a non-gradient method, PTO is simple to understand, easy to implement, and is also efficient and accurate at the same time. It is…

Computational Engineering, Finance, and Science · Computer Science 2016-05-30 Emre Biyikli , Albert C. To

The development of artificial intelligence (AI) for science has led to the emergence of learning-based research paradigms, necessitating a compelling reevaluation of the design of multi-objective optimization (MOO) methods. The new…

Machine Learning · Computer Science 2023-11-02 Linxi Yang , Xinmin Yang , Liping Tang

Over the past decades, engineering systems have developed as networks of systems that deliver multiple services across multiple domains. This work aims to develop an optimization program for a dynamic, hetero-functional graph theory-based…

Systems and Control · Electrical Eng. & Systems 2021-04-02 Wester C. H. Schoonenberg , Amro M. Farid

Structural optimization (topology, shapes, sizing) is an important tool for facilitating the emergence of new concepts in structural design. Normally, topology optimization is carried out at the early stage of design and then shape and…

Optimization and Control · Mathematics 2021-03-16 Ghislain Raze , Joseph Morlier

Topology Optimization (TO) provides a systematic approach for obtaining structure design with optimum performance of interest. However, the process requires numerical evaluation of objective function and constraints at each iteration, which…

Machine Learning · Computer Science 2022-03-22 Ren Kai Tan , Chao Qian , Dan Xu , Wenjing Ye

Flow-based generative models, including diffusion models, excel at modeling continuous distributions in high-dimensional spaces. In this work, we introduce Flow Policy Optimization (FPO), a simple on-policy reinforcement learning algorithm…

Machine Learning · Computer Science 2025-08-04 David McAllister , Songwei Ge , Brent Yi , Chung Min Kim , Ethan Weber , Hongsuk Choi , Haiwen Feng , Angjoo Kanazawa

Topology optimization (TO) is a popular and powerful computational approach for designing novel structures, materials, and devices. Two computational challenges have limited the applicability of TO to a variety of industrial applications.…

Computational Engineering, Finance, and Science · Computer Science 2020-12-01 Sirui Bi , Jiaxin Zhang , Guannan Zhang

The parameter size of modern large language models (LLMs) can be scaled up via the sparsely-activated Mixture-of-Experts (MoE) technique to avoid excessive increase of the computational costs. To further improve training efficiency,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-08 Yunqi Gao , Bing Hu , Mahdi Boloursaz Mashhadi , A-Long Jin , Yanfeng Zhang , Pei Xiao , Rahim Tafazolli , Merouane Debbah

Microfluidic devices are gaining attention for their small size and ability to handle tiny fluid volumes. Mixing fluids efficiently at this scale, known as micromixing, is crucial. This article builds upon previous research by introducing a…

This paper introduces a novel optimization framework for deep neural network (DNN) hardware accelerators, enabling the rapid development of customized and automated design flows. More specifically, our approach aims to automate the…

Machine Learning · Computer Science 2023-11-08 Zhiqiang Que , Shuo Liu , Markus Rognlien , Ce Guo , Jose G. F. Coutinho , Wayne Luk

In traditional topology optimization, the computing time required to iteratively update the material distribution within a design domain strongly depends on the complexity or size of the problem, limiting its application in real engineering…

Computational Engineering, Finance, and Science · Computer Science 2024-05-14 Gabriel Garayalde , Matteo Torzoni , Matteo Bruggi , Alberto Corigliano

In this paper, we propose PATO-a producibility-aware topology optimization (TO) framework to help efficiently explore the design space of components fabricated using metal additive manufacturing (AM), while ensuring manufacturability with…

Computational Engineering, Finance, and Science · Computer Science 2021-12-10 Naresh S. Iyer , Amir M. Mirzendehdel , Sathyanarayanan Raghavan , Yang Jiao , Erva Ulu , Morad Behandish , Saigopal Nelaturi , Dean M. Robinson