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The organization of live cells into tissues and their subsequent biological function involves inter-cell mechanical interactions, which are mediated by their elastic environment. To model this interaction, we consider cells as spherical…

Soft Condensed Matter · Physics 2024-02-20 Roman Golkov , Yair Shokef

This paper considers the motion of an object subjected to dry friction and an external random force. The objective is to characterize the role of the correlation time of the external random force. We develop efficient stochastic simulation…

Statistical Mechanics · Physics 2023-09-26 Josselin Garnier , Laurent Mertz

Stochastic interactions generically enhance self-diffusivity in living and biological systems, e.g. optimizing navigation strategies and controlling material properties of cellular tissues and bacterial aggregates. Despite this, the…

Soft Condensed Matter · Physics 2024-01-24 Henry Alston , Thibault Bertrand

The expansion of biological species in natural environments is usually described as the combined effect of individual spatial dispersal and growth. In the case of aquatic ecosystems flow transport can also be extremely relevant as an extra,…

Biological Physics · Physics 2016-08-30 Francesca Tesser , Jos C. H. Zeegers , Herman J. H. Clercx , Luc Brunsveld , Federico Toschi

We investigated the energy transfer from active enzymes to their surroundings in crowded environments by measuring the diffusion of passive microscopic tracers in active solutions of ficoll and glycerol. Despite observing lower rates of…

Most spreading processes require spatial proximity between agents. The stationary state of spreading dynamics in a population of mobile agents thus depends on the interplay between the time and length scales involved in the epidemic process…

Statistical Mechanics · Physics 2024-03-05 Jorge P. Rodríguez , Matteo Paoluzzi , Demian Levis , Michele Starnini

Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…

Biological Physics · Physics 2018-10-02 Hervé Turlier , Timo Betz

We study the transport of bacteria in a porous media modeled by a square channel containing one cylindrical obstacle via molecular dynamics simulations coupled to a lattice Boltzmann fluid. Our bacteria model is a rod-shaped rigid body…

Soft Condensed Matter · Physics 2020-11-30 Miru Lee , Christoph Lohrmann , Kai Szuttor , Harold Auradou , Christian Holm

Bacterial swarming is a rapid mass-migration, in which thousands of cells spread collectively to colonize a surface. Physically, swarming is a natural example of active particles that use energy to generate motion. Accordingly,…

Soft Condensed Matter · Physics 2019-11-14 Avraham Be`er , Bella Ilkanaiv , Renan Gross , Daniel B. Kearns , Sebastian Heidenreich , Markus Bär , Gil Ariel

Respiration in bacteria involves a sequence of energetically-coupled electron and proton transfers creating an electrochemical gradient of protons (a proton-motive force) across the inner bacterial membrane. With a simple kinetic model we…

Biological Physics · Physics 2015-05-13 Anatoly Yu. Smirnov , Sergey E. Savel'ev , Franco Nori

Run-and-tumble motility is widely used by swimming microorganisms including numerous prokaryotic eukaryotic organisms. Here, we experimentally investigate the run-and-tumble dynamics of the bacterium E. coli in polymeric solutions. We find…

Fluid Dynamics · Physics 2015-11-04 A. E. Patteson , A. Gopinath , M. Goulian , P. E. Arratia

Eukaryotic cells adhere to extracellular matrix during the normal development of the organism, forming static adhesion as well as during cell motility. We study this process by considering a simplified coarse-grained model of a vesicle that…

Biological Physics · Physics 2021-01-05 Raj Kumar Sadhu , Samo Penič , Aleš Iglič , Nir S. Gov

Bacteria commonly live in structured communities that affect human health and influence ecological systems. Heterogeneous populations, such as motile and non-motile populations, often coexist in bacteria communities. Motile subpopulations…

Biological Physics · Physics 2019-06-19 Haoran Xu , Justas Dauparas , Debasish Das , Eric Lauga , Yilin Wu

Can activity be transmitted from smaller to larger scales? We report on such a transfer from a homogeneous active medium to a Newtonian spherical probe. The active medium consists of faster and dilute self-propelled particles, modeled as…

Statistical Mechanics · Physics 2025-12-30 Ji-Hui Pei , Christian Maes

Many biological systems form colonies at high density. Passive granular systems will be jammed at such densities, yet for the survival of biological systems it is crucial that they are dynamic. We construct a phase diagram for a system of…

Soft Condensed Matter · Physics 2019-08-13 Daniel R. McCusker , Ruben van Drongelen , Timon Idema

Microbial interactions regulate their spread and survival in competitive environments. It is not clear if the physical parameters of the environment regulate the outcome of these interactions. In this work, we show that the opportunistic…

Cell Behavior · Quantitative Biology 2023-09-12 Divakar Badal , Aloke Kumar , Varsha Singh , Danny Raj M

Quantifying the outcomes of cells collisions is a crucial step in building the foundations of a kinetic theory of living matter. Here, we develop a mechanical theory of such collisions by first representing individual cells as extended…

Biological Physics · Physics 2019-12-11 Pierre Recho , Thibaut Putelat , Lev Truskinovsky

The diffusion properties of self-propelled particles which move at constant speed and, in addition, reverse their direction of motion repeatedly are investigated. The internal dynamics of particles triggering these reversal processes is…

Biological Physics · Physics 2016-05-30 Robert Großmann , Fernando Peruani , Markus Bär

Dense monolayers of living cells display intriguing relaxation dynamics, reminiscent of soft and glassy materials close to the jamming transition, and migrate collectively when space is available, as in wound healing or in cancer invasion.…

Mechanical forces are obviously important in the assembly of three-dimensional multicellular structures, but their detailed role is often unclear. We have used growing microcolonies of the bacterium \emph{Escherichia coli} to investigate…

Cell Behavior · Quantitative Biology 2014-02-17 Matthew A. A. Grant , Bartłomiej Wacław , Rosalind J. Allen , Pietro Cicuta
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