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Variational Quantum Algorithms (VQAs) are promising methods for solving combinatorial optimization problems on noisy intermediate-scale quantum (NISQ) devices. However, benchmarking VQAs is difficult due to their stochastic behavior and the…

In this work we are interested in the construction of numerical methods for high dimensional constrained nonlinear optimization problems by particle-based gradient-free techniques. A consensus-based optimization (CBO) approach combined with…

Optimization and Control · Mathematics 2021-11-23 Giacomo Borghi , Michael Herty , Lorenzo Pareschi

We present approximation algorithms for the following NP-hard optimization problems related to bottleneck spanning trees in metric spaces. 1. The disjoint bottleneck spanning tree problem: Given $n$ pairs of points in a metric space, find…

Computational Geometry · Computer Science 2021-11-11 Ahmad Biniaz , Anil Maheshwari , Michiel Smid

Variational quantum circuits for image classification suffer from barren plateaus, while quantum kernel methods scale quadratically with dataset size. We propose an iterative framework based on Quadratic Unconstrained Binary Optimization…

Quantum Physics · Physics 2026-03-04 Mostafa Atallah , Rebekah Herrman

Over the last decade, concepts such as industry 4.0 and the Internet of Things (IoT) have contributed to the increase in the availability and affordability of sensing technology. In this context, Structural Health Monitoring (SHM) arises as…

Systems and Control · Electrical Eng. & Systems 2024-01-10 Gabriel San Martin Silva , Enrique Lopez Droguett

We aim to advance the state-of-the-art in Quadratic Unconstrained Binary Optimization formulation with a focus on cryptography algorithms. As the minimal QUBO encoding of the linear constraints of optimization problems emerges as the…

Cryptography and Security · Computer Science 2026-04-16 Gregory Morse , Tamás Kozsik , Oskar Mencer , Peter Rakyta

A binary constant weight code is a type of error-correcting code with a wide range of applications. The problem of finding a binary constant weight code has long been studied as a combinatorial optimization problem in coding theory. In this…

Quantum Physics · Physics 2022-11-10 Kein Yukiyoshi , Naoki Ishikawa

Answering complex logical queries on incomplete knowledge graphs is a challenging task, and has been widely studied. Embedding-based methods require training on complex queries, and cannot generalize well to out-of-distribution query…

Machine Learning · Computer Science 2023-06-08 Yushi Bai , Xin Lv , Juanzi Li , Lei Hou

Combinatorial optimization problems play a central role in computer science with many real world applications. A number of relevant problems remain computationally difficult to solve as they lie in the NP-hard complexity class. We present a…

Quantum Physics · Physics 2026-05-11 Kapil Goswami , Peter Schmelcher

Quadratic Unconstrained Binary Optimization models are useful for solving a diverse range of optimization problems. Constraints can be added by incorporating quadratic penalty terms into the objective, often with the introduction of slack…

Optimization and Control · Mathematics 2021-05-18 Amit Verma , Mark Lewis

Spanning tree problems with specialized constraints can be difficult to solve in real-world scenarios, often requiring intricate algorithmic design and exponential time. Recently, there has been growing interest in end-to-end deep neural…

Machine Learning · Computer Science 2023-06-13 Yuchen Shi , Congying Han , Tiande Guo

We use exact enumeration to characterize the solutions of quadratic unconstrained binary optimization problems of less than 21 variables in terms of their distributions of Hamming distances to close-by solutions. We also perform experiments…

Quantum Physics · Physics 2025-11-04 Vrinda Mehta , Fengping Jin , Kristel Michielsen , Hans De Raedt

This paper introduces the use of tailored variational forms for variational quantum eigensolver that have properties of representing certain constraints on the search domain of a linear constrained quadratic binary optimization problem…

Quantum Physics · Physics 2020-11-30 Miguel Paredes Quinones , Catarina Junqueira

Quantum and quantum-inspired optimisation algorithms are designed to solve problems represented in binary, quadratic and unconstrained form. Combinatorial optimisation problems are therefore often formulated as Quadratic Unconstrained…

Artificial Intelligence · Computer Science 2022-05-27 Mayowa Ayodele , Richard Allmendinger , Manuel López-Ibáñez , Matthieu Parizy

Spanning trees are an important primitive in many data analysis tasks, when a data set needs to be summarized in terms of its "skeleton", or when a tree-shaped graph over all observations is required for downstream processing. Popular…

Discrete Mathematics · Computer Science 2024-04-10 Enrique Fita Sanmartín , Christoph Schnörr , Fred A. Hamprecht

The Cable Routing Optimization Problem (CROP) is a Multi-Commodity Flow Problem (MCFP) central to industrial layouts and smart manufacturing. Historically, quantum optimization has modeled MCFPs as Quadratic Unconstrained Binary…

The present work provides a new approach to evolve ligand structures which represent possible drug to be docked to the active site of the target protein. The structure is represented as a tree where each non-empty node represents a…

Neural and Evolutionary Computing · Computer Science 2016-11-15 Avishek Ghosh , Arnab Ghosh , Arkabandhu Chowdhury , Jubin Hazra

Assembling genomes from short-read sequencing data remains difficult in repetitive regions, where reference bias and combinatorial complexity limit existing methods. Pangenome-guided sequence assembly (PGSA) mitigates reference bias by…

Quantum Physics · Physics 2026-04-08 Josh Cudby , Sergii Strelchuk

The D-Wave quantum annealing machine can quickly find the optimal solution for quadratic unconstrained binary optimization (QUBO). One of the applications where the use of quantum annealing is desired is in problems requiring rapid…

Quantum Physics · Physics 2024-12-11 Reo Shikanai , Masayuki Ohzeki , Kazuyuki Tanaka

Quantum annealers offer a promising hardware platform for solving combinatorial optimization problems, especially those formulated as Quadratic Unconstrained Binary Optimization (QUBO). In this work, we propose PDQUBO (Performance-Driven…

Information Retrieval · Computer Science 2026-05-01 Jiayang Niu , Jie Li , Ke Deng , Mark Sanderson , Nicola Ferro , Yongli Ren