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COVID-19 pandemic, is still unknown and is an important open question. There are speculations that bats are a possible origin. Likewise, there are many closely related (corona-) viruses, such as SARS, which was found to be transmitted…

Genomics · Quantitative Biology 2022-01-10 Sarwan Ali , Babatunde Bello , Prakash Chourasia , Ria Thazhe Punathil , Yijing Zhou , Murray Patterson

Sequence-to-Sequence models were introduced to tackle many real-life problems like machine translation, summarization, image captioning, etc. The standard optimization algorithms are mainly based on example-to-example matching like maximum…

Computation and Language · Computer Science 2018-09-05 Wenhu Chen , Guanlin Li , Shujie Liu , Zhirui Zhang , Mu Li , Ming Zhou

The accuracy and complexity of machine learning algorithms based on kernel optimization are determined by the set of kernels over which they are able to optimize. An ideal set of kernels should: admit a linear parameterization (for…

Machine Learning · Statistics 2024-10-30 Aleksandr Talitckii , Brendon K. Colbert , Matthew M. Peet

We give sublinear-time approximation algorithms for some optimization problems arising in machine learning, such as training linear classifiers and finding minimum enclosing balls. Our algorithms can be extended to some kernelized versions…

Machine Learning · Computer Science 2010-10-22 Kenneth L. Clarkson , Elad Hazan , David P. Woodruff

Mixtures of linear mixed models (MLMMs) are useful for clustering grouped data and can be estimated by likelihood maximization through the EM algorithm. The conventional approach to determining a suitable number of components is to compare…

Applications · Statistics 2014-05-26 Siew Li Tan , David J. Nott

Spectral clustering refers to a family of unsupervised learning algorithms that compute a spectral embedding of the original data based on the eigenvectors of a similarity graph. This non-linear transformation of the data is both the key of…

Machine Learning · Computer Science 2019-01-30 Nicolas Tremblay , Andreas Loukas

Quantum computing, with its potential to enhance various machine learning tasks, allows significant advancements in kernel calculation and model precision. Utilizing the one-class Support Vector Machine alongside a quantum kernel, known for…

This paper describes a method to efficiently retrieve protein database sequences similar to a query sequence, while allowing for significant numbers of mutations. We call this method SEQR for SEQuence Retrieval. This approach increases the…

Genomics · Quantitative Biology 2018-11-05 David I. Hurwitz , Lianyi Han , Lewis Y. Geer

Many similarity-based clustering methods work in two separate steps including similarity matrix computation and subsequent spectral clustering. However, similarity measurement is challenging because it is usually impacted by many factors,…

Machine Learning · Computer Science 2017-05-04 Zhao Kang , Chong Peng , Qiang Cheng

Representation learning is an important step in the machine learning pipeline. Given the current biological sequencing data volume, learning an explicit representation is prohibitive due to the dimensionality of the resulting feature…

Machine Learning · Computer Science 2023-04-04 Sarwan Ali , Usama Sardar , Murray Patterson , Imdad Ullah Khan

Recent advances in healthcare technologies have led to the availability of large amounts of biological samples across several techniques and applications. In particular, in the last few years, Raman spectroscopy analysis of biological…

Quantitative Methods · Quantitative Biology 2025-06-24 Marco Piazza , Andrea Spinelli , Francesca Maggioni , Marzia Bedoni , Enza Messina

This paper proposes a frequent pattern data mining algorithm based on support vector machine (SVM), aiming to solve the performance bottleneck of traditional frequent pattern mining algorithms in high-dimensional and sparse data…

Machine Learning · Computer Science 2024-12-23 Pochun Li

Support vector machine (SVM) is a particularly powerful and flexible supervised learning model that analyzes data for both classification and regression, whose usual algorithm complexity scales polynomially with the dimension of data space…

Machine Learning · Computer Science 2023-03-08 Chen Ding , Tian-Yi Bao , He-Liang Huang

Multiple kernel learning algorithms are proposed to combine kernels in order to obtain a better similarity measure or to integrate feature representations coming from different data sources. Most of the previous research on such methods is…

Machine Learning · Computer Science 2012-07-03 Mehmet Gonen

The support vector machine (SVM) algorithm is well known to the computer learning community for its very good practical results. The goal of the present paper is to study this algorithm from a statistical perspective, using tools of…

Statistics Theory · Mathematics 2008-12-18 Gilles Blanchard , Olivier Bousquet , Pascal Massart

This work concerns a comparison of SVM kernel methods in text categorization tasks. In particular I define a kernel function that estimates the similarity between two objects computing by their compressed lengths. In fact, compression…

Machine Learning · Computer Science 2012-10-30 Antonio Giuliano Zippo

We study the problem of efficiently clustering protein sequences in a limited information setting. We assume that we do not know the distances between the sequences in advance, and must query them during the execution of the algorithm. Our…

Data Structures and Algorithms · Computer Science 2015-03-17 Konstantin Voevodski , Maria-Florina Balcan , Heiko Roglin , Shang-Hua Teng , Yu Xia

This paper presents a new, parallel implementation of clustering and demonstrates its utility in greatly speeding up the process of identifying homologous proteins. Clustering is a technique to reduce the number of comparison needed to find…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-29 Stuart Byma , Akash Dhasade , Adrian Altenhoff , Christophe Dessimoz , James R. Larus

Early detection and characterization of coronavirus disease (COVID-19), caused by SARS-CoV-2, remain critical for effective clinical response and public-health planning. The global availability of large-scale viral sequence data presents…

Machine Learning · Computer Science 2025-12-12 Sarwan Ali , Taslim Murad

By facilitating the generation of samples from arbitrary probability distributions, Markov Chain Monte Carlo (MCMC) is, arguably, \emph{the} tool for the evaluation of Bayesian inference problems that yield non-standard posterior…

Computation · Statistics 2021-05-27 Peter L Green , Robert E Moore , Ryan J Jackson , Jinglai Li , Simon Maskell