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Causal or unconfounded descriptive comparisons between multiple groups are common in observational studies. Motivated from a racial disparity study in health services research, we propose a unified propensity score weighting framework, the…

Methodology · Statistics 2019-07-10 Fan Li , Fan Li

Biomedical studies that use electronic health records (EHR) data for inference are often subject to bias due to measurement error. The measurement error present in EHR data is typically complex, consisting of errors of unknown functional…

Methodology · Statistics 2020-06-16 Eric J. Oh , Bryan E. Shepherd , Thomas Lumley , Pamela A. Shaw

Comparing outcomes across hospitals, often to identify underperforming hospitals, is a critical task in health services research. However, naive comparisons of average outcomes, such as surgery complication rates, can be misleading because…

Applications · Statistics 2021-02-16 Luke Keele , Eli Ben-Michael , Avi Feller , Rachel Kelz , Luke Miratrix

Missingness in variables that define study eligibility criteria is a seldom addressed challenge in electronic health record (EHR)-based settings. It is typically the case that patients with incomplete eligibility information are excluded…

The new era of large-scale data collection and analysis presents an opportunity for diagnosing and understanding the causes of health inequities. In this study, we describe a framework for systematically analyzing health disparities using…

The emergency department (ED) is a high stress environment with increased risk of clinician bias exposure. In the United States, Black patients are more likely than other racial/ethnic groups to obtain their first schizophrenia (SCZ)…

Other Quantitative Biology · Quantitative Biology 2026-04-14 Alissa A. Valentine , Lauren A. Lepow , Donald Apakama , Lili Chan , Alexander W. Charney , Isotta Landi

Practitioners in diverse fields such as healthcare, economics and education are eager to apply machine learning to improve decision making. The cost and impracticality of performing experiments and a recent monumental increase in electronic…

Machine Learning · Computer Science 2023-08-01 Fredrik D. Johansson , Uri Shalit , Nathan Kallus , David Sontag

Though they may offer valuable patient and disease information that is impossible to study in a randomized trial, clinical disease registries also require special care and attention in causal inference. Registry data may be incomplete,…

Applications · Statistics 2019-05-07 Pallavi Mishra-Kalyani , Brent A. Johnson , Jonathan D. Glass , Qi Long

Standard practice in electronic health record (EHR)-based studies evaluating the comparative effectiveness of bariatric surgery relative to no surgery is to estimate and report a constant treatment effect across calendar time. However,…

Persistent demographic disparities have been identified in the treatment of patients seeking care in the emergency department (ED). These may be driven in part by subconscious biases, which providers themselves may struggle to identify. To…

Methods for extending -- generalizing or transporting -- inferences from a randomized trial to a target population involve conditioning on a large set of covariates that is sufficient for rendering the randomized and non-randomized groups…

Methodology · Statistics 2021-10-04 Sarah E Robertson , Jon A Steingrimsson , Issa J Dahabreh

Estimation of heterogeneous treatment effects is an essential component of precision medicine. Model and algorithm-based methods have been developed within the causal inference framework to achieve valid estimation and inference. Existing…

Methodology · Statistics 2021-05-10 Ruohong Li , Honglang Wang , Wanzhu Tu

Congenital heart defects (CHD) are the most prevalent birth defects in the United States and surgical outcomes vary considerably across the country. The outcomes of treatment for CHD differ for specific patient subgroups, with non-Hispanic…

Weighting methods are used in observational studies to adjust for covariate imbalances between treatment and control groups. Entropy balancing (EB) is an alternative to inverse probability weighting with an estimated propensity score. The…

Methodology · Statistics 2022-04-25 David Källberg , Ingeborg Waernbaum

This study employs a robust analytical framework to uncover patterns in survival outcomes among breast cancer patients from diverse racial and geographical backgrounds. This research uses the SEER 2021 dataset to analyze breast cancer…

Machine Learning · Computer Science 2025-06-10 Ramisa Farha , Joshua O. Olukoya

Racial disparities in healthcare expenditures are well-documented, yet the underlying drivers remain complex. This study develops a framework to decompose such disparities through shifts in the distributions of mediating variables, rather…

Applications · Statistics 2026-03-31 Xiaxian Ou , Xinwei He , David Benkeser , Razieh Nabi

During the growing popularity of electronic medical records, electronic medical record (EMR) data has exploded increasingly. It is very meaningful to retrieve high quality EMR in mass data. In this paper, an EMR value network with retrieval…

Computer Vision and Pattern Recognition · Computer Science 2019-11-22 Yongpei Zhu , Xuesheng Zhang , Kehong Yuan

Scientists frequently generalize population level causal quantities such as average treatment effect from a source population to a target population. When the causal effects are heterogeneous, differences in subject characteristics between…

Methodology · Statistics 2023-06-16 Rui Chen , Guanhua Chen , Menggang Yu

Selection bias is a major obstacle toward valid causal inference in epidemiology. Over the past decade, several graphical rules based on causal diagrams have been proposed as the sufficient identification conditions for addressing selection…

Methodology · Statistics 2025-12-18 Yichi Zhang , Haidong Lu

Causal inference methods based on electronic health record (EHR) databases must simultaneously handle confounding and missing data. Vast scholarship exists aimed at addressing these two issues separately, but surprisingly few papers attempt…

Methodology · Statistics 2025-07-28 Luke Benz , Alexander Levis , Sebastien Haneuse
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