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In biological systems, molecular-scale forces and motions are pivotal for enabling processes like motility, shape change, and replication. These forces and motions are organized, amplified, and transmitted across macroscopic scales by…

Active cellular transport is a fundamental mechanism for protein and vesicle delivery, cell cycle and molecular degradation. Viruses can hijack the transport system and use it to reach the nucleus. Most transport processes consist of…

Quantitative Methods · Quantitative Biology 2009-11-13 T. Lagache , D. Holcman

During Saccharomyces cerevisiae closed mitosis, parental identity is sustained by the asymmetric segregation of ageing factors. Such asymmetry has been hypothesized to occur via diffusion barriers, constraining protein lateral exchange in…

Subcellular Processes · Quantitative Biology 2014-07-29 Eder Zavala , Tatiana T. Marquez-Lago

The intracellular environment is a dynamic space filled with various organelles moving in all directions. Included in this diverse group of organelles are vesicles, which are involved in transport of molecular cargo throughout the cell.…

Biological Physics · Physics 2018-09-07 Danielle Posey , Paris Blaisdell-Pijuan , Samantha K. Knoll , Taher A. Saif , Wylie W. Ahmed

Within living cells, the transport of cargo is accomplished by groups of molecular motors. Such collective transport could utilize mechanisms which emerge from inter-motor interactions in ways that are yet to be fully understood. Here we…

Biomolecules · Quantitative Biology 2016-10-04 David Ando , Michelle K. Mattson , Jing Xu , Ajay Gopinathan

Transport of molecules across membrane channels is investigated theoretically using exactly solvable discrete stochastic site-binding models. It is shown that the interaction potential between molecules and the channel has a strong effect…

Soft Condensed Matter · Physics 2009-11-11 Anatoly B. Kolomeisky

Cytoskeletal motor proteins are involved in major intracellular transport processes which are vital for maintaining appropriate cellular function. The motor exhibits distinct states of motility: active motion along filaments, and…

Biological Physics · Physics 2016-11-29 Anne E. Hafner , Ludger Santen , Heiko Rieger , M. Reza Shaebani

The kinesin superfamily of motor proteins is a major driver of anterograde transport of vesicles and organelles within eukaryotic cells via microtubules. Numerous studies have elucidated the step-size, velocities, forces, and navigation…

Biomolecules · Quantitative Biology 2024-10-07 Mason Grieb , Nimisha Krishnan , Jennifer L. Ross

Proteins with nontrivial topology, containing knots and slipknots, have the ability to fold to their native states without any additional external forces invoked. A mechanism is suggested for folding of these proteins, such as YibK and…

Biomolecules · Quantitative Biology 2010-01-06 Joanna I. Sułkowska , Piotr Sułkowski , José N. Onuchic

Intracellular transport of cargoes in the cell is essential for the organization and functioning cells, especially those that are large and elongated. The cytoskeletal networks inside large cells can be highly complex, and this cytoskeletal…

Biological Physics · Physics 2023-08-04 Nimisha Krishnan , Niranjan Sarpangala , Maria Gamez , Ajay Gopinathan , Jennifer L Ross

Insects exhibit remarkable cognitive skills in the field and several cognitive abilities have been demonstrated in Drosophila in the laboratory. By devising an ethologically relevant experimental setup that also allows comparison of…

Neurons and Cognition · Quantitative Biology 2016-02-17 Shay Cohen , Yoav Benjamini , Ilan Golani

Li$_2$MnO$_3$ is a key component of Li-excess layered cathodes of the form $(1-x),\mathrm{LiMO_2} + x,\mathrm{Li_2MnO_3}$ ($M$ = Mn, Ni, Co, \dots), yet its role in setting Li-ion transport limitations remains under debate. Here we combine…

Materials Science · Physics 2026-05-29 Alex Taekyung Lee , Kristin A. Persson , Anh T. Ngo

In the current study, we demonstrated that allostery transpires by entropy transfers across time-spatial scales that actualize the conception of a molecular trap that supervises ligand interaction, selection, and migration into the…

Biological Physics · Physics 2021-08-30 Leroy K. Davis

Liquid-liquid phase separation has emerged as a fundamental mechanism underlying intracellular organization, with evidence for it being reported in numerous different systems. However, there is a growing concern regarding the lack of…

Soft Condensed Matter · Physics 2022-12-09 Mrityunjay Kothari , Tal Cohen

A model of postphotodissociative monomolecular (geminate) recombination of heme proteins with small ligands (NO, O2 or CO) is represented. The non-exponential decay with time for the probability to find a heme in unbound state is…

Biological Physics · Physics 2009-11-07 V. S. Starovoitov , B. M. Dzhagarov

Colloids and proteins alike can bind to lipid bilayers and move laterally in these two-dimensional fluids. Inspired by proteins that generate membrane curvature, sense the underlying membrane geometry, and migrate to high curvature sites,…

We study the dynamics of a pair of atoms, resonantly interacting with a single mode cavity, in the situation where the atoms enter the cavity with a time delay between them. Using time dependent coupling functions to represent the spatial…

Quantum Physics · Physics 2010-10-15 C. Lazarou , B. M. Garraway

The potential for low-threshold optical nonlinearity has received significant attention in the fields of photonics and conceptual optical neuron networks. Excitons in two-dimensional (2D) semiconductors are particularly promising in this…

Protein machines often exhibit long range interplay between different sites in order to achieve their biological tasks. We investigate and characterize the non--linear energy localization and the basic mechanisms of energy transfer in…

Biological Physics · Physics 2015-12-14 M. Caraglio , A. Imparato

We investigate by Molecular-Dynamics simulations the fast mobility - the rattling amplitude of the particles temporarily trapped by the cage of the neighbors - in mildly supercooled states of dense molecular (linear trimers) and atomic…

Fluid Dynamics · Physics 2016-05-04 S. Bernini , F. Puosi , D. Leporini
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