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In this paper we present a method for locating transition states and higher-order saddles on potential energy surfaces using double-ended classical trajectories. We then apply this method to 7- and 8-atom Lennard-Jones clusters, finding one…

chem-ph · Physics 2009-10-22 A. Matro , D. L. Freeman , J. D. Doll

The complexity and unpredictability of postbuckling responses in even simple thin shells have raised great challenges to emerging technologies exploiting buckling transitions. Here we comprehensively survey the buckling landscapes to show…

Materials Science · Physics 2019-10-22 Jack Panter , Junbo Chen , Teng Zhang , Halim Kusumaatmaja

Many problems in physics, material sciences, chemistry and biology can be abstractly formulated as a system that navigates over a complex energy landscape of high or infinite dimensions. Well-known examples include phase transitions of…

Numerical Analysis · Mathematics 2025-10-20 Weinan E , Weiqing Ren , Eric Vanden-Eijnden

We present a new and efficient method for computing the transition pathways, free energy barriers, and transition rates in complex systems with relatively smooth energy landscapes. The method proceeds by evolving strings, i.e. smooth curves…

Condensed Matter · Physics 2009-11-07 Weinan E , Weiqing Ren , Eric Vanden-Eijnden

We present Bayesian Binary Search (BBS), a novel probabilistic variant of the classical binary search/bisection algorithm. BBS leverages machine learning/statistical techniques to estimate the probability density of the search space and…

Machine Learning · Computer Science 2024-10-03 Vikash Singh , Matthew Khanzadeh , Vincent Davis , Harrison Rush , Emanuele Rossi , Jesse Shrader , Pietro Lio

A novel and powerful method is presented for the study of rare switching events in complex systems with multiscale energy landscapes. The method performs an umbrella sampling of the equilibrium distribution of the system in hyperplanes…

Condensed Matter · Physics 2007-05-23 Weinan E , Weiqing Ren , Eric Vanden-Eijnden

Efficient state space models (SSMs), such as linear recurrent neural networks and linear attention variants, offer computational advantages over Transformers but struggle with tasks requiring long-range in-context retrieval-like text…

Computation and Language · Computer Science 2025-02-25 Sam Blouir , Jimmy T. H. Smith , Antonios Anastasopoulos , Amarda Shehu

Energy landscapes provide a valuable means for studying the folding dynamics of short RNA molecules in detail by modeling all possible structures and their transitions. Higher abstraction levels based on a macro-state decomposition of the…

Biomolecules · Quantitative Biology 2014-09-09 Martin Mann , Marcel Kucharik , Christoph Flamm , Michael T. Wolfinger

Iterative deepening search is used in applications where the best cost bound for state-space search is unknown. The iterative deepening process is used to avoid overshooting the appropriate cost bound and doing too much work as a result.…

Artificial Intelligence · Computer Science 2019-06-10 Nathan Sturtevant , Malte Helmert

A modification of the nudged elastic band (NEB) method is presented that enables stable optimisations to be run using both the limited-memory quasi-Newton (L-BFGS) and slow-response quenched velocity Verlet (SQVV) minimisers. The…

Other Condensed Matter · Physics 2009-11-10 Semen A. Trygubenko , David J. Wales

This paper applies Benders decomposition to two-stage stochastic problems for energy planning under climate uncertainty, a key problem for the design of renewable energy systems. To improve performance, we adapt various refinements for…

Optimization and Control · Mathematics 2024-01-29 Leonard Göke , Felix Schmidt , Mario Kendziorski

We develop an efficient algorithm to implement the recently introduced binary tree state (BTS) ansatz on a classical computer. BTS allows a simple approximation to permanents arising from the computationally intractable antisymmetric…

Chemical Physics · Physics 2024-03-01 Rishab Dutta , Fei Gao , Armin Khamoshi , Thomas M. Henderson , Gustavo E. Scuseria

Transition state (TS) searches are a critical bottleneck in computational studies of chemical reactivity, as accurately capturing complex phenomena like bond breaking and formation events requires repeated evaluations of expensive ab-initio…

Chemical Physics · Physics 2025-09-23 Jonah Marks , Joseph Gomes

Practical use of neural networks often involves requirements on latency, energy and memory among others. A popular approach to find networks under such requirements is through constrained Neural Architecture Search (NAS). However, previous…

Machine Learning · Computer Science 2022-04-28 Niv Nayman , Yonathan Aflalo , Asaf Noy , Rong Jin , Lihi Zelnik-Manor

Various real-life applications, for example, Internet of Things, wireless sensor networks, smart grids, transportation networks, communication networks, social networks, and computer grid systems, are always modeled as network structures.…

Networking and Internet Architecture · Computer Science 2021-11-23 Wei-Chang Yeh

Network structures and models have been widely adopted, e.g., for Internet of Things, wireless sensor networks, smart grids, transportation networks, communication networks, social networks, and computer grid systems. Network reliability is…

Data Structures and Algorithms · Computer Science 2020-04-20 Wei-Chang Yeh

Projected Entangled Pair States (PEPS) are recognized as a potent tool for exploring two-dimensional quantum many-body systems. However, a significant challenge emerges when applying conventional PEPS methodologies to systems with periodic…

Strongly Correlated Electrons · Physics 2024-07-23 Shaojun Dong , Chao Wang , Hao Zhang , Meng Zhang , Lixin He

Neural network quantum states are a promising tool to analyze complex quantum systems given their representative power. It can however be difficult to optimize efficiently and effectively the parameters of this type of ansatz. Here we…

Quantum Physics · Physics 2023-05-10 Wenxuan Zhang , Xiansong Xu , Zheyu Wu , Vinitha Balachandran , Dario Poletti

Energy landscape models characterize neural dynamics by assigning energy values to each brain state that reflect their stability or probability of occurrence. The conventional energy landscape models rely on binary brain state…

Signal Processing · Electrical Eng. & Systems 2026-01-13 Triet M. Tran , Seyed Majid Razavi , Dee H. Wu , Sina Khanmohammadi

The `lid' algorithm performs an exhaustive exploration of neighborhoods of local energy minima of energy landscapes. This paper describes an implementation of the algorithm, including issues of parallel performance and scalability. To…

Computational Physics · Physics 2009-10-31 Paolo Sibani , Ruud van der Pas , J. Christian Schoen
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