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Here we present a structural similarity index measure (SSIM) guided conditional Generative Adversarial Network (cGAN) that generatively performs image-to-image (i2i) synthesis to generate photo-accurate protein channels in multiplexed…

Image and Video Processing · Electrical Eng. & Systems 2024-01-08 Jillur Rahman Saurav , Mohammad Sadegh Nasr , Paul Koomey , Michael Robben , Manfred Huber , Jon Weidanz , Bríd Ryan , Eytan Ruppin , Peng Jiang , Jacob M. Luber

Automatic histopathology image segmentation is crucial to disease analysis. Limited available labeled data hinders the generalizability of trained models under the fully supervised setting. Semi-supervised learning (SSL) based on generative…

Computer Vision and Pattern Recognition · Computer Science 2020-12-18 Hongxiao Wang , Hao Zheng , Jianxu Chen , Lin Yang , Yizhe Zhang , Danny Z. Chen

We present SinDiffusion, leveraging denoising diffusion models to capture internal distribution of patches from a single natural image. SinDiffusion significantly improves the quality and diversity of generated samples compared with…

Computer Vision and Pattern Recognition · Computer Science 2022-11-23 Weilun Wang , Jianmin Bao , Wengang Zhou , Dongdong Chen , Dong Chen , Lu Yuan , Houqiang Li

Sonography synthesis has a wide range of applications, including medical procedure simulation, clinical training and multimodality image registration. In this paper, we propose a machine learning approach to simulate ultrasound images at…

Machine Learning · Computer Science 2017-09-19 Yipeng Hu , Eli Gibson , Li-Lin Lee , Weidi Xie , Dean C. Barratt , Tom Vercauteren , J. Alison Noble

In recent years, the use of deep learning is becoming increasingly popular in computer vision. However, the effective training of deep architectures usually relies on huge sets of annotated data. This is critical in the medical field where…

Image and Video Processing · Electrical Eng. & Systems 2019-07-30 Paolo Andreini , Simone Bonechi , Monica Bianchini , Alessandro Mecocci , Franco Scarselli , Andrea Sodi

We propose a segmentation framework that uses deep neural networks and introduce two innovations. First, we describe a biophysics-based domain adaptation method. Second, we propose an automatic method to segment white and gray matter, and…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Amir Gholami , Shashank Subramanian , Varun Shenoy , Naveen Himthani , Xiangyu Yue , Sicheng Zhao , Peter Jin , George Biros , Kurt Keutzer

Digitized pathological diagnosis has been in increasing demand recently. It is well known that color information is critical to the automatic and visual analysis of pathological slides. However, the color variations due to various factors…

Image and Video Processing · Electrical Eng. & Systems 2024-02-13 Shaojin Cai , Yuyang Xue3 Qinquan Gao , Min Du , Gang Chen , Hejun Zhang , Tong Tong

As a powerful technique in medical imaging, image synthesis is widely used in applications such as denoising, super resolution and modality transformation etc. Recently, the revival of deep neural networks made immense progress in the field…

Image and Video Processing · Electrical Eng. & Systems 2021-04-23 Gengyan Zhao , Mary E. Meyerand , Rasmus M. Birn

Unsupervised and unpaired domain translation using generative adversarial neural networks, and more precisely CycleGAN, is state of the art for the stain translation of histopathology images. It often, however, suffers from the presence of…

Computer Vision and Pattern Recognition · Computer Science 2022-07-04 Nicolas Brieu , Felix J. Segerer , Ansh Kapil , Philipp Wortmann , Guenter Schmidt

Tumor synthesis enables the creation of artificial tumors in medical images, facilitating the training of AI models for tumor detection and segmentation. However, success in tumor synthesis hinges on creating visually realistic tumors that…

Image and Video Processing · Electrical Eng. & Systems 2024-03-29 Qi Chen , Xiaoxi Chen , Haorui Song , Zhiwei Xiong , Alan Yuille , Chen Wei , Zongwei Zhou

Medical Image Segmentation is a useful application for medical image analysis including detecting diseases and abnormalities in imaging modalities such as MRI, CT etc. Deep learning has proven to be promising for this task but usually has a…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Soham Bhosale , Arjun Krishna , Ge Wang , Klaus Mueller

Semantic image synthesis is a challenging task with many practical applications. Albeit remarkable progress has been made in semantic image synthesis with spatially-adaptive normalization and existing methods normalize the feature…

Computer Vision and Pattern Recognition · Computer Science 2022-04-07 Yupeng Shi , Xiao Liu , Yuxiang Wei , Zhongqin Wu , Wangmeng Zuo

Semantic Image Synthesis (SIS) is a subclass of image-to-image translation where a semantic layout is used to generate a photorealistic image. State-of-the-art conditional Generative Adversarial Networks (GANs) need a huge amount of paired…

Computer Vision and Pattern Recognition · Computer Science 2023-05-17 George Eskandar , Mohamed Abdelsamad , Karim Armanious , Shuai Zhang , Bin Yang

Multisequence Magnetic Resonance Imaging (MRI) provides a more reliable diagnosis in clinical applications through complementary information across sequences. However, in practice, the absence of certain MR sequences is a common problem…

Image and Video Processing · Electrical Eng. & Systems 2025-10-21 Jihoon Cho , Jonghye Woo , Jinah Park

The annotation of large scale histopathology image datasets remains a major bottleneck in developing robust deep learning models for clinically relevant tasks, such as mitotic figure classification. Folder-based annotation workflows are…

Histopathology can help clinicians make accurate diagnoses, determine disease prognosis, and plan appropriate treatment strategies. As deep learning techniques prove successful in the medical domain, the primary challenges become limited…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Zhe Li , Bernhard Kainz

Generating realistic synthetic microscopy images is critical for training deep learning models in label-scarce environments, such as cell counting with many cells per image. However, traditional domain adaptation methods often struggle to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Mohammad Dehghanmanshadi , Wallapak Tavanapong

Nuclei instance segmentation is critical in computational pathology for cancer diagnosis and prognosis. Recently, the Segment Anything Model has demonstrated exceptional performance in various segmentation tasks, leveraging its rich priors…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Jingze Su , Tianle Zhu , Jiaxin Cai , Zhiyi Wang , Qi Li , Xiao Zhang , Tong Tong , Shu Wang , Wenxi Liu

We propose a new method for cancer subtype classification from histopathological images, which can automatically detect tumor-specific features in a given whole slide image (WSI). The cancer subtype should be classified by referring to a…

Computer Vision and Pattern Recognition · Computer Science 2020-04-03 Noriaki Hashimoto , Daisuke Fukushima , Ryoichi Koga , Yusuke Takagi , Kaho Ko , Kei Kohno , Masato Nakaguro , Shigeo Nakamura , Hidekata Hontani , Ichiro Takeuchi

Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tissues and staining conditions. To address…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kazuya Nishimura , Ryoma Bise , Haruka Hirose , Yasuhiro Kojima