Related papers: Sharp dose profiles for high precision proton ther…

Purpose: Variations in proton Relative Biological Effectiveness (RBE) with Linear Energy Transfer (LET) remain one of the largest sources of uncertainty in proton radiotherapy. This work seeks to identify physics-based metrics which can be…

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription…

Background and purpose: In-beam Positron Emission Tomography (PET) is one of the modalities that can be used for in-vivo non-invasive treatment monitoring in proton therapy. PET distributions obtained during various treatment sessions can…

Cone beam CT (CBCT) has been widely used for patient setup in image guided radiation therapy (IGRT). Radiation dose from CBCT scans has become a clinical concern. The purposes of this study are 1) to commission a GPU-based Monte Carlo (MC)…

In radiotherapy, a trade-off exists between computational workload/speed and dose calculation accuracy. Calculation methods like pencil-beam convolution can be much faster than Monte-Carlo methods, but less accurate. The dose difference,…

Non-coplanar Intensity-Modulated Radiation Therapy (IMRT) goes a step further by orienting the gantry carrying the radiation beam and the patient couch in a non-coplanar manner to accurately target the cancer region and better avoid…

The paper reports the results of two-dimensional particle-in-cell simulations of proton beam acceleration at the interactions of a 130 fs laser pulse of intensity from the range of 10^21-10^23 W/cm^2, predicted for the Extreme Light…

Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

Purpose: We present a framework for robust automated treatment planning using machine learning, comprising scenario-specific dose prediction and robust dose mimicking. Methods: The scenario dose prediction pipeline is divided into the…

FLASH Radiotherapy (RT) is a potentially new cancer radiotherapy technique where an entire therapeutic dose is delivered in about 0.1 s and at ~1000 times higher dose rate than in conventional RT. For clinical trials to be conducted safely,…

Adaptive Radiation Therapy (ART) was developed based on Image-guided Radiation Therapy (IGRT) and it is the trend of photon radiation therapy. To get a better use of Cone Beam CT (CBCT) images for ART, the CBCT system model was established…

Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam scanning system can deliver 250 MeV (the highest energy), it…

Accurate dose distribution prediction is crucial in the radiotherapy planning. Although previous methods based on convolutional neural network have shown promising performance, they have the problem of over-smoothing, leading to prediction…

Purpose: There is growing interest in the use of modern 3D printing technology to implement intensity-modulated radiation therapy (IMRT) on the preclinical scale which is analogous to clinical IMRT. However, current 3D-printed IMRT methods…

Dense high-energy monoenergetic proton beams are vital for wide applications, thus modern laser-plasma-based ion acceleration methods are aiming to obtain high-energy proton beams with energy spread as low as possible. In this work, we put…

Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

Due to its precision and limited side effects, the particle therapy of cancer is gaining popularity. The number of patients treated with protons and light ions reached 150,000 worldwide. There are currently more than 80 facilities, which…

Intensity modulated proton therapy (IMPT) provides highly conformal dose distributions through the application of multiple, angularly spaced fields, each applying an ad-hoc pattern of spatially varying particle fluences. In particular,…

Purpose: Currently, calculations of proton range in proton therapy patients are based on a conversion of CT Hounsfield Units of patient tissues into proton relative stopping power. Uncertainties in this conversion necessitate larger…

The distribution of the prompt gamma emissions induced by proton interactions in a target material carries information concerning the proton range and target composition. In order to image prompt gamma we present different approaches. The…