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"Is it possible to predict expression levels of different genes at a given spatial location in the routine histology image of a tumor section by modeling its stain absorption characteristics?" In this work, we propose a "stain-aware"…

Image and Video Processing · Electrical Eng. & Systems 2021-08-27 Muhammad Dawood , Kim Branson , Nasir M. Rajpoot , Fayyaz ul Amir Afsar Minhas

Current methods for diagnosing the progression of multiple types of cancer within patients rely on interpreting stained needle biopsies. This process is time-consuming and susceptible to error throughout the paraffinization, Hematoxylin and…

Image and Video Processing · Electrical Eng. & Systems 2022-04-19 Benjamin Paulson , Theodore Colwell , Natalia Bukowski , Joseph Weller , Andrew Crisler , John Cisler , Alexander Drobek , Alexander Neuwirth

Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Niccoló Marini , Manfredo Atzori , Sebastian Otálora , Stephane Marchand-Maillet , Henning Müller

Deep learning has proven to be more effective than other methods in medical image analysis, including the seemingly simple but challenging task of segmenting individual cells, an essential step for many biological studies. Comparative…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Valentina Vadori , Antonella Peruffo , Jean-Marie Graïc , Livio Finos , Livio Corain , Enrico Grisan

This paper addresses the problem of automatically detecting human skin in images without reliance on color information. A primary motivation of the work has been to achieve results that are consistent across the full range of skin tones,…

Computer Vision and Pattern Recognition · Computer Science 2022-04-26 Han Xu , Abhijit Sarkar , A. Lynn Abbott

Domain shift in digital histopathology can occur when different stains or scanners are used, during stain translation, etc. A deep neural network trained on source data may not generalise well to data that has undergone some domain shift.…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Zeeshan Nisar , Jelica Vasiljević , Pierre Gançarski , Thomas Lampert

Real-world deployment of computer vision systems, including in the discovery processes of biomedical research, requires causal representations that are invariant to contextual nuisances and generalize to new data. Leveraging the internal…

Computer Vision and Pattern Recognition · Computer Science 2023-06-22 Wolfgang M. Pernice , Michael Doron , Alex Quach , Aditya Pratapa , Sultan Kenjeyev , Nicholas De Veaux , Michio Hirano , Juan C. Caicedo

Domain shift in the field of histopathological imaging is a common phenomenon due to the intra- and inter-hospital variability of staining and digitization protocols. The implementation of robust models, capable of creating generalized…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Ilán Carretero , Pablo Meseguer , Rocío del Amor , Valery Naranjo

We propose a new method for producing color images from sketches. Current solutions in sketch colorization either necessitate additional user instruction or are restricted to the "paired" translation strategy. We leverage semantic image…

Computer Vision and Pattern Recognition · Computer Science 2023-01-23 Samet Hicsonmez , Nermin Samet , Emre Akbas , Pinar Duygulu

The automated analysis of medical images is currently limited by technical and biological noise and bias. The same source tissue can be represented by vastly different images if the image acquisition or processing protocols vary. For an…

Virtual stain transfer leverages computer-assisted technology to transform the histochemical staining patterns of tissue samples into other staining types. However, existing methods often lose detailed pathological information due to the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Haiyan Wei , Hangrui Xu , Bingxu Zhu , Yulian Geng , Aolei Liu , Wenfei Yin , Jian Liu

Biological imaging data are often partially confounded or contain unwanted variability. Examples of such phenomena include variable lighting across microscopy image captures, stain intensity variation in histological slides, and batch…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Craig A. Glastonbury , Michael Ferlaino , Christoffer Nellåker , Cecilia M. Lindgren

Video color style transfer aims to transform the color style of an original video by using a reference style image. Most existing methods employ neural networks, which come with challenges like opaque transfer processes and limited user…

Computer Vision and Pattern Recognition · Computer Science 2024-11-04 Xintao Jiang , Yaosen Chen , Siqin Zhang , Wei Wang , Xuming Wen

Deep learning approaches to the segmentation of magnetic resonance images have shown significant promise in automating the quantitative analysis of brain images. However, a continuing challenge has been its sensitivity to the variability of…

Image and Video Processing · Electrical Eng. & Systems 2021-03-05 Dzung L. Pham , Yi-Yu Chou , Blake E. Dewey , Daniel S. Reich , John A. Butman , Snehashis Roy

Compared to hematoxylin-eosin (H&E) staining, immunohistochemistry (IHC) not only maintains the structural features of tissue samples, but also provides high-resolution protein localization, which is essential for aiding in pathology…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Yuhang Kang , Ziyu Su , Tianyang Wang , Zaibo Li , Wei Chen , Muhammad Khalid Khan Niazi

Colorization of grayscale images has been a hot topic in computer vision. Previous research mainly focuses on producing a colored image to match the original one. However, since many colors share the same gray value, an input grayscale…

Computer Vision and Pattern Recognition · Computer Science 2017-07-04 Yun Cao , Zhiming Zhou , Weinan Zhang , Yong Yu

Skin lesion datasets consist predominantly of normal samples with only a small percentage of abnormal ones, giving rise to the class imbalance problem. Also, skin lesion images are largely similar in overall appearance owing to the low…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Hasib Zunair , A. Ben Hamza

Three-dimensional X-ray histology techniques offer a non-invasive alternative to conventional 2D histology, enabling volumetric imaging of biological tissues without the need for physical sectioning or chemical staining. However, the…

Image and Video Processing · Electrical Eng. & Systems 2025-09-12 Sarah C. Irvine , Christian Lucas , Diana Krüger , Bianca Guedert , Julian Moosmann , Berit Zeller-Plumhoff

The colorization of grayscale images is an ill-posed problem, with multiple correct solutions. In this paper, we propose an adversarial learning colorization approach coupled with semantic information. A generative network is used to infer…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Patricia Vitoria , Lara Raad , Coloma Ballester

Generated images of score-based models can suffer from errors in their spatial means, an effect, referred to as a color shift, which grows for larger images. This paper investigates a previously-introduced approach to mitigate color shifts…

Machine Learning · Computer Science 2023-11-30 Katherine Deck , Tobias Bischoff
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