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Intracellular networks process cellular-level information and control cell fate. They can be computationally modeled using Boolean networks, which are implicit-time causal models of discrete binary events. These networks can be embedded in…

Molecular Networks · Quantitative Biology 2025-01-28 John Metzcar , Katie Pletz , Heber L. Rocha , Jordan C Rozum

A modeling formalism is proposed for the description and study of living and life-like systems. It provides an abstract conceptual model framework for real life and evolution of biological organisms. It is proposed, that this model…

Populations and Evolution · Quantitative Biology 2013-06-14 Margareta Segerståhl

A Boolean network (BN) is a discrete dynamical system defined by a Boolean function that maps to the domain itself. A trap space of a BN is a generalization of a fixed point, which is defined as the sub-hypercubes closed by the function of…

Discrete Mathematics · Computer Science 2024-10-21 Kyungduk Moon , Kangbok Lee , Loïc Paulevé

We present BoolSi, an open-source cross-platform command line tool for distributed simulations of deterministic Boolean networks with synchronous update. It uses MPI standard to support execution on computational clusters, as well as…

Molecular Networks · Quantitative Biology 2019-10-22 Vladyslav Oles , Anton Kukushkin

Bayesian experimental design (BED) is a framework that uses statistical models and decision making under uncertainty to optimise the cost and performance of a scientific experiment. Sequential BED, as opposed to static BED, considers the…

Machine Learning · Statistics 2020-03-23 Steven Kleinegesse , Christopher Drovandi , Michael U. Gutmann

The rapid growth of the size and complexity in deep neural networks has sharply increased computational demands, challenging their efficient deployment in real-world scenarios. Boolean networks, constructed with logic gates, offer a…

Machine Learning · Computer Science 2024-09-12 Youngsung Kim

The nature of distributed computation has often been described in terms of the component operations of universal computation: information storage, transfer and modification. We review the first complete framework that quantifies each of…

Cellular Automata and Lattice Gases · Physics 2014-01-23 Joseph T. Lizier , Mikhail Prokopenko , Albert Y. Zomaya

Probabilistic Circuits (PCs) have emerged as an efficient framework for representing and learning complex probability distributions. Nevertheless, the existing body of research on PCs predominantly concentrates on data-driven parameter…

Machine Learning · Computer Science 2024-12-20 Athresh Karanam , Saurabh Mathur , Sahil Sidheekh , Sriraam Natarajan

Probabilistic programming systems enable users to encode model structure and naturally reason about uncertainties, which can be leveraged towards improved Bayesian optimization (BO) methods. Here we present a probabilistic program embedding…

Artificial Intelligence · Computer Science 2019-02-06 Alexander Lavin

Neural networks are dynamical systems that compute with their dynamics. One example is the Hopfield model, forming an associative memory which stores patterns as global attractors of the network dynamics. From studies of dynamical networks…

Emerging Technologies · Computer Science 2021-12-13 Lorenz Baumgarten , Stefan Bornholdt

A new analytical framework consisting of two phenomena: single sample and multiple samples, is proposed to deal with the identification problem of Boolean control networks (BCNs) systematically and comprehensively. Under this framework, the…

Systems and Control · Electrical Eng. & Systems 2021-04-30 Biao Wang , Jun-e Feng , Daizhan Cheng

Inspired by recent successes with parallel optimization techniques for solving Boolean satisfiability, we investigate a set of strategies and heuristics that aim to leverage parallel computing to improve the scalability of neural network…

Logic in Computer Science · Computer Science 2020-08-24 Haoze Wu , Alex Ozdemir , Aleksandar Zeljić , Ahmed Irfan , Kyle Julian , Divya Gopinath , Sadjad Fouladi , Guy Katz , Corina Pasareanu , Clark Barrett

The parallel simulation of Spiking Neural P systems is mainly based on a matrix representation, where the graph inherent to the neural model is encoded in an adjacency matrix. The simulation algorithm is based on a matrix-vector…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-08-09 Javier Hernández-Tello , Miguel Ángel Martínez-del-Amor , David Orellana-Martín , Francis George C. Cabarle

We investigate a correspondence between two formalisms for discrete probabilistic modeling: probabilistic graphical models (PGMs) and tensor networks (TNs), a powerful modeling framework for simulating complex quantum systems. The graphical…

Machine Learning · Statistics 2021-07-01 Jacob Miller , Geoffrey Roeder , Tai-Danae Bradley

Continuum solvation models are becoming increasingly relevant in condensed matter simulations, allowing to characterize materials interfaces in the presence of wet electrified environments at a reduced computational cost with respect to all…

Computational Physics · Physics 2023-08-16 Gabriel Medrano , Edan Bainglass , Oliviero Andreussi

Structural controllability has been proposed as an analytical framework for making predictions regarding the control of complex networks across myriad disciplines in the physical and life sciences (Liu et al., Nature:473(7346):167-173,…

Physics and Society · Physics 2015-05-28 Noah J. Cowan , Erick J. Chastain , Daril A. Vilhena , James S. Freudenberg , Carl T. Bergstrom

The applicability of computational models to the biological world is an active topic of debate. We argue that a useful path forward results from abandoning hard boundaries between categories and adopting an observer-dependent, pragmatic…

Multiagent Systems · Computer Science 2022-12-22 Joshua Bongard , Michael Levin

Predictive coding has emerged as an influential normative model of neural computation, with numerous extensions and applications. As such, much effort has been put into mapping PC faithfully onto the cortex, but there are issues that remain…

Neurons and Cognition · Quantitative Biology 2023-03-07 Siavash Golkar , Tiberiu Tesileanu , Yanis Bahroun , Anirvan M. Sengupta , Dmitri B. Chklovskii

We consider efficiency in the implementation of deep neural networks. Hardware accelerators are gaining interest as machine learning becomes one of the drivers of high-performance computing. In these accelerators, the directed graph…

Machine Learning · Computer Science 2021-04-28 George A. Constantinides

The accelerating technological landscape and drive towards net-zero emission made the power system grow in scale and complexity. Serial computational approaches for grid planning and operation struggle to execute necessary calculations…

Systems and Control · Electrical Eng. & Systems 2022-07-07 Ahmed Al-Shafei , Hamidreza Zareipour , Yankai Cao