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Deterministic Lateral Displacement (DLD) devices are widely used in microfluidics for label-free, size-based separation of particles and cells, with particular promise in isolating circulating tumor cells (CTCs) for early cancer…

Machine Learning · Computer Science 2025-11-25 Elizabeth Chen , Andrew Lee , Tanbir Sarowar , Xiaolin Chen

Deterministic Lateral Displacement (DLD) devices enable liquid biopsy for cancer detection by separating circulating tumor cells (CTCs) from blood samples based on size, but designing these microfluidic devices requires computationally…

Machine Learning · Computer Science 2025-11-25 Andrew Lee , Mahir Mobarrat , Xiaolin Chen

Sorting cells based on their mechanical properties is essential for applications in disease diagnostics, cell therapy, and biomedical research. Deterministic Lateral Displacement (DLD) devices provide a label-free method for achieving such…

Quantitative Methods · Quantitative Biology 2025-12-08 Khayrul Islam , Mehedi Hasan , Yaling Liu

Deterministic lateral displacement (DLD) is a high-resolution separation technique used in various fields. A fundamental challenge in DLD is ensuring uniform flow characteristics across channel, particularly near sidewalls where pillar…

Fluid Dynamics · Physics 2025-06-10 Aryan Mehboudi , Shrawan Singhal , S. V. Sreenivasan

Deterministic lateral displacement (DLD) devices separate micrometer-scale particles in solution based on their size using a laminar microfluidic flow in an array of obstacles. We investigate array geometries with rational row-shift…

We solve a design optimization problem for deterministic lateral displacement (DLD) device to sort same-size biological cells by their deformability, in particular to sort red blood cells (RBCs) by their viscosity contrast between the fluid…

Computational Physics · Physics 2019-01-14 Gokberk Kabacaoglu , George Biros

An important step in diagnostics is the isolation of specific cells and microorganisms of interest from blood. Since such bioparticles are often present at very low concentrations, throughput needs to be as high as possible. In addition, to…

Soft Condensed Matter · Physics 2019-07-31 Stefan H. Holm , Zunmin Zhang , Jason P. Beech , Gerhard Gompper , Dmitry A. Fedosov , Jonas O. Tegenfeldt

We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating…

Soft Condensed Matter · Physics 2015-10-27 Rohan Vernekar , Timm Krüger

An electrokinetically-driven deterministic lateral displacement (e-DLD) device is proposed for the continuous, two-dimensional fractionation of suspensions in microfluidic platforms. The suspended species are driven through an array of…

Fluid Dynamics · Physics 2016-05-04 Srinivas Hanasoge , Raghavendra Devendra , Javier F. Diez , German Drazer

Deterministic lateral displacement (DLD) is a popular technique for size-based separation of particles. One of the challenges in design of DLD chips is to eliminate the disturbance of fluid flow patterns caused by channel sidewalls…

Fluid Dynamics · Physics 2025-03-25 Aryan Mehboudi , Shrawan Singhal , S. V. Sreenivasan

The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based…

Fluid Dynamics · Physics 2014-04-15 Timothy J. Bowman , German Drazer , Joelle Frechette

Sorting cells based on their intrinsic properties is a highly desirable objective, since changes in cell deformability are often associated with various stress conditions and diseases. Deterministic lateral displacement (DLD) devices offer…

Fluid Dynamics · Physics 2024-06-03 Zunmin Zhang , Wei Chien , Ewan Henry , Dmitry A. Fedosov , Gerhard Gompper

We present Latent Diffeomorphic Dynamic Mode Decomposition (LDDMD), a new data reduction approach for the analysis of non-linear systems that combines the interpretability of Dynamic Mode Decomposition (DMD) with the predictive power of…

Machine Learning · Computer Science 2025-08-04 Willem Diepeveen , Jon Schwenk , Andrea Bertozzi

Deterministic lateral displacement (DLD) microfluidic devices promise versatile and precise processing of biological samples. However, this prospect has been realized so far only for rigid spherical particles and remains limited for…

Soft Condensed Matter · Physics 2024-06-03 Wei Chien , Zunmin Zhang , Gerhard Gompper , Dmitry A. Fedosov

Laser-based manufacturing has emerged as a promising alternative to conventional thermal and mechanical processing owing to its precision, versatility, and ability to work across diverse materials. In particular, tailoring the spatial…

Lightweight design, as a key approach to mitigate disparity between computational requirements of deep learning models and hardware performance, plays a pivotal role in advancing application of deep learning technologies on mobile and…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Hanhua Long , Wenbin Bi , Jian Sun

This paper presents a unified framework for codifying and automating optimization strategies to efficiently deploy deep neural networks (DNNs) on resource-constrained hardware, such as FPGAs, while maintaining high performance, accuracy,…

Hardware Architecture · Computer Science 2026-02-11 Zhiqiang Que , Jose G. F. Coutinho , Ce Guo , Hongxiang Fan , Wayne Luk

Applying deep neural networks (DNNs) in mobile and safety-critical systems, such as autonomous vehicles, demands a reliable and efficient execution on hardware. Optimized dedicated hardware accelerators are being developed to achieve this.…

Machine Learning · Computer Science 2019-10-01 Christoph Schorn , Thomas Elsken , Sebastian Vogel , Armin Runge , Andre Guntoro , Gerd Ascheid

Diffractive neural network (DNN), which can perform machine learning tasks based on the light propagation and diffraction, has recently emerged as a promising optical computing paradigm due to its high parallel processing speed and low…

Optics · Physics 2026-01-27 Yudong Tian , Haifeng Xu , Yuqing Liu , Xiangyu Zhao , Jierong Cheng , Chongzhao Wu

Predicting the evolution of systems that exhibit spatio-temporal dynamics in response to external stimuli is a key enabling technology fostering scientific innovation. Traditional equations-based approaches leverage first principles to…

Machine Learning · Computer Science 2023-05-02 Francesco Regazzoni , Stefano Pagani , Matteo Salvador , Luca Dede' , Alfio Quarteroni
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