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The differentiation between pathological subtypes of non-small cell lung cancer (NSCLC) is an essential step in guiding treatment options and prognosis. However, current clinical practice relies on multi-step staining and labelling…

Quantitative Methods · Quantitative Biology 2026-03-10 Zhenya Zang , David A Dorward , Katherine E Quiohilag , Andrew DJ Wood , James R Hopgood , Ahsan R Akram , Qiang Wang

Histological analysis of tissue samples is one of the most widely used methods for disease diagnosis. After taking a sample from a patient, it goes through a lengthy and laborious preparation, which stains the tissue to visualize different…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Yair Rivenson , Hongda Wang , Zhensong Wei , Yibo Zhang , Harun Gunaydin , Aydogan Ozcan

Human exposure to Volatile Organic Compounds (VOCs) and their presence in indoor and working environments is recognized as a serious health risk, causing impairment of varying severity. Different detecting systems able to monitor VOCs are…

Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…

Medical Physics · Physics 2025-10-30 Talia Xu , Caitlin Smith , Charles Lo , Jami Shepherd , Gijs van Soest , Marco Zuniga

The photo-kinetics of fluorescent molecules have enabled the circumvention of far-field optical diffraction-limit. Despite its enormous potential, the necessity to label the sample may adversely influence the delicate biology under…

Citrus greening, or Huanglongbing (HLB), is a serious disease affecting citrus crops, with no known cure. Early detection is essential, but current methods are often expensive. To address this, a low-cost, portable sensor was developed to…

Other Quantitative Biology · Quantitative Biology 2025-09-04 Ramji Gupta , Ashis Kumar Das , Sushmita Mena , Saurav Bharadwaj

We introduce the holographic air-quality monitor (HAM) system, uniquely tailored for monitoring large particulate matter (PM) over 10 um in diameter, i.e., particles critical for disease transmission and public health but overlooked by most…

Instrumentation and Detectors · Physics 2024-09-09 Nicholas Bravo-Frank , Lei Feng , Jiarong Hong

In the past decades, absorption modalities have emerged as powerful tools for label-free functional and structural imaging of cells and tissues. Many biomolecules present unique absorption spectra providing chromophore-specific information…

Photoacoustic imaging has emerged as a powerful, non-invasive modality for various biomedical applications. Conventional photoacoustic systems require contact-based ultrasound detection and expensive and bulky high-power lasers for the…

Applied Physics · Physics 2025-01-06 Emiel Dieussaert , Roel Baets , Hilde Jans , Xavier Rottenberg , Yanlu Li

Heavy metal pollution, particularly in the form of airborne aerosols such as lead (Pb), cadmium (Cd), mercury (Hg), and cobalt (Co), poses serious health and environmental risks, necessitating highly sensitive remote detection techniques.…

Instrumentation and Detectors · Physics 2025-06-12 Yuezheng Wang , Lu Sun , Zhiwenqi An , Jiayun Xue , Zhixuan An , Nan Zhang , Lie Lin , Weiwei Liu

In this letter, we propose a dielectric-modulated Impact-Ionization MOS (DIMOS) transistor based sensor for application in label-free detection of biomolecules. Numerous reports exist on the experimental demonstration of nanogap-embedded…

Mesoscale and Nanoscale Physics · Physics 2014-03-28 N. Kannan , M. Jagadesh Kumar

This paper proposes a novel wireless, battery-free, and label-free biosensor for minimally invasive and non-invasive permittivity sensing for applications such as detecting glucose levels in the interstitial dermal fluid. The miniaturized,…

Applied Physics · Physics 2022-10-19 Rehab S. Hassan

This paper presents a non-contact vital signs (respiration and heartbeat) monitoring system that utilizes visible light sensing (VLS) technology. We have for the first time demonstrated the ability to wirelessly (non-contact) sense vital…

Signal Processing · Electrical Eng. & Systems 2019-12-17 Hisham Abuella , Sabit Ekin

An UV-VIS polarization Lidar has been designed and specified for aerosols monitoring in the troposphere, showing the ability to precisely address low particle depolarization ratios, in the range of a few percents. Non-spherical particle…

Atmospheric and Oceanic Physics · Physics 2017-08-23 G. David , A. Miffre , B. Thomas , P. Rairoux

Biofouling is the accumulation of organisms on surfaces immersed in water. It is of particular concern to the international shipping industry because it increases fuel costs and presents a biosecurity risk by providing a pathway for…

Computer Vision and Pattern Recognition · Computer Science 2021-02-22 Nathaniel J. Bloomfield , Susan Wei , Bartholomew Woodham , Peter Wilkinson , Andrew Robinson

Obtaining in situ measurements of biological microparticles is crucial for both scientific research and numerous industrial applications (e.g., early detection of harmful algal blooms, monitoring yeast during fermentation). However,…

Biological Physics · Physics 2023-01-25 Delaney Sanborn , Ruichen He , Lei Feng , Jiarong Hong

Biosensors are an essential tool for medical diagnostics, environmental monitoring and food safety. Typically, biosensors are designed to detect specific analytes through functionalization with the appropriate capture agents. However, the…

Medical Physics · Physics 2023-09-26 Simon J. Ward , Tengfei Cao , Xiang Zhou , Catie Chang , Sharon M. Weiss

Fiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, the state-of-the-art micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use…

Optics · Physics 2022-11-09 Noam Badt , Ori Katz

Marine debris poses a significant ecological threat to birds, fish, and other animal life. Traditional methods for assessing debris accumulation involve labor-intensive and costly manual surveys. This study introduces a framework that…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Raymond Wang , Nicholas R. Record , D. Whitney King , Tahiya Chowdhury

One of the most important processes in the fight against current and future pandemics is the rapid diagnosis and initiation of treatment of viruses in humans. In these times, the development of high-sensitivity tests and diagnostic kits is…

Optics · Physics 2022-12-13 Junfei Wang , Zhenyu Xu , Domna G. Kotsifaki