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In this paper, we present a decision support framework for optimizing multiple aspects of vaccine distribution across a multitier cold chain network. We propose two multi-period optimization formulations within this framework: first to…

Physics and Society · Physics 2022-01-12 Shanmukhi Sripada , Ayush Jain , Prasanna Ramamoorthy , Varun Ramamohan

This research investigates a multi-product, multi-echelon, and multi-period vaccine supply chain network model under uncertainty and quality inspection errors. The objective function seeks optimizing the total cost of the supply chain.…

Optimization and Control · Mathematics 2024-05-07 Bouchenine Abderrahmen , Almaraj Ismail

During various stages of the COVID-19 pandemic, countries implemented diverse vaccine management approaches, influenced by variations in infrastructure and socio-economic conditions. This article provides a comprehensive overview of…

Optimization and Control · Mathematics 2024-05-27 Shibshankar Dey , Ali Kaan Kurbanzade , Esma S. Gel , Joseph Mihaljevic , Sanjay Mehrotra

Vaccinating the global population against Covid-19 is one of the biggest supply chain management challenges humanity has ever faced. Rapid supply of Covid-19 vaccines is essential for successful global immunization, but its effectiveness…

Cryptography and Security · Computer Science 2022-09-22 Soroush Goodarzi , Vahid Kayvanfar , Alireza Haji , Alireza Shirzad

Millions of young people are not immunized in low- and middle-income (LMI) countries because of low vaccine availability resulting from inefficiencies in cold supply chains. We create supply chain network design and distribution models to…

Applications · Statistics 2020-06-11 Zahra Azadi , Sandra D. Eksioglu , H. Neil Geismar

Vaccines play a crucial role in the prevention and control of infectious diseases. However, the vaccine supply chain faces numerous challenges that hinder its efficiency. To address these challenges and enhance public health outcomes, many…

Theoretical Economics · Economics 2025-10-07 Ran Gu , Enhui Ding , Shigui Ma

With the approval of vaccines for the coronavirus disease by many countries worldwide, most developed nations have begun, and developing nations are gearing up for the vaccination process. This has created an urgent need to provide a…

Computers and Society · Computer Science 2021-02-09 Mahzabeen Emu , Dhivya Chandrasekaran , Vijay Mago , Salimur Choudhury

This research is about COVID-19, which is a contagious virus that reached many countries, including Lebanon. Monitoring the outbreak, researchers have been involved in introducing COVID-19 targeting vaccines. Already facing financial and…

Applications · Statistics 2023-12-22 Sarkis Der Wartanian , Baydaa Al Ayoubi

The COVID19 pandemic has highlighted the lack of resilience in supply chains, as global networks fail from disruptions at single nodes and connections. Through an overview of the existing vaccine and pharmaceutical supply chain publications…

Physics and Society · Physics 2020-12-01 Maureen S. Golan , Benjamin D. Trump , Jeffrey C. Cegan , Igor Linkov

Purpose: Only few companies were able to produce vaccine again COVID-19. Thus, one producer supplied it to many countries. The distribution was not effective. Some countries overstocked the vaccine while other countries were not able to buy…

Physics and Society · Physics 2024-08-20 Béla Vizvári , Gergely Kovács

Timely and effective decision-making is critical during epidemics to reduce preventable infections and deaths. This demands integrated models that jointly capture disease dynamics, vaccine distribution, regional disparities, and behavioral…

Social and Information Networks · Computer Science 2025-11-26 Kimiya Jozani , Nihal A. Sageer , Hode Eldardiry , Sait Tunc , Esra Buyuktahtakin Toy

The recent global outbreak of covid-19 is affecting many countries around the world. Due to the growing number of newly infected individuals and the health-care system bottlenecks, it will be useful to predict the upcoming number of…

Machine Learning · Computer Science 2021-03-18 Jafar Abdollahi , Amir Jalili Irani , Babak Nouri-Moghaddam

The COVID-19 pandemic exposed critical vulnerabilities in vaccine supply chains, highlighting the need for robust manufacturing for rapid pandemic response to support CEPI's 100 Days Mission. We develop a discrete-event simulation model to…

General Economics · Economics 2026-02-10 Robin Kelchtermans , Valentijn Stienen , Guido Dietrich , Mauro Bernuzzi , Nico Vandaele

The COVID-19 vaccine development, manufacturing, transportation, and administration proved an extreme logistics operation of global magnitude. Global vaccination levels, however, remain a key concern in preventing the emergence of new…

General Economics · Economics 2025-01-10 Sharika J. Hegde , Max T. M. Ng , Marcos Rios , Hani S. Mahmassani , Ying Chen , Karen Smilowitz

With the continuous rise of the COVID-19 cases worldwide, it is imperative to ensure that all those vulnerable countries lacking vaccine resources can receive sufficient support to contain the risks. COVAX is such an initiative operated by…

Computational Engineering, Finance, and Science · Computer Science 2022-01-20 Navpreet Kaur , Jason Hughes , Juntao Chen

How to ensure accessibility to food and nutrition while food supply chains suffer from demand and supply uncertainties caused by disruptive forces such as the COVID-19 pandemic and natural disasters is an emerging and critical issue.…

General Economics · Economics 2024-06-14 Mengfei Chen , Mohamed Kharbeche , Mohamed Haouari , Weihong "Grace" Guo

Since early 2020, the world has been dealing with a raging pandemic outbreak: COVID-19. A year later, vaccines have become accessible, but in limited quantities, so that governments needed to devise a strategy to decide which part of the…

Populations and Evolution · Quantitative Biology 2022-04-13 Sander Tonkens , Paul de Klaver , Mauro Salazar

As observed during the COVID-19 pandemic, high-income countries, such as the U.S., may exhibit vaccine nationalism during a pandemic: stockpiling doses of vaccine for their own citizens and being reluctant to distribute doses of the vaccine…

Populations and Evolution · Quantitative Biology 2024-08-21 Abraham Holleran , Susan E. Martonosi , Michael Veatch

The outbreak of COVID-19 led to a record-breaking race to develop a vaccine. However, the limited vaccine capacity creates another massive challenge: how to distribute vaccines to mitigate the near-end impact of the pandemic? In the United…

Populations and Evolution · Quantitative Biology 2021-07-20 Dimitris Bertsimas , Vassilis Digalakis , Alexander Jacquillat , Michael Lingzhi Li , Alessandro Previero

The focus of this research is to evaluate the use of drones for the delivery of pediatric vaccines in remote areas of low income and low and middle income countries. Delivering vaccines in these regions is challenging because of the…

Optimization and Control · Mathematics 2022-08-10 Maximilian Kolter , Sandra D. Eksioglu , Sarah Nurre Pinkley , Ruben A. Proano
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