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Surface tension governed by differential adhesion can drive fluid particle mixtures to sort into separate regions, i.e., demix. Does the same phenomenon occur in confluent biological tissues? We begin to answer this question for epithelial…

The existence of a phase transition between two distinct liquid phases in single-component network-forming liquids (e.g., water, silica, silicon) has elicited considerable scientific interest. The challenge, both for experiments and…

Soft Condensed Matter · Physics 2022-05-30 Yagyik Goswami , Srikanth Sastry

Motility-induced phase separation, MIPS, is arguably the most well-studied collective phenomenon occurring in active matter without alignment interactions (scalar active matter). Its basic origin is simple: since self-propelled particles…

Soft Condensed Matter · Physics 2021-12-10 Joakim Stenhammar

Collectives of actively-moving particles can spontaneously separate into dilute and dense phases -- a fascinating phenomenon known as motility-induced phase separation (MIPS). MIPS is well-studied for randomly-moving particles with no…

Biological Physics · Physics 2023-01-31 Hongbo Zhao , Andrej Košmrlj , Sujit S. Datta

We consider a mixture of passive (i.e., Brownian) and active (e.g., bacterial or colloidal swimmers) particles, and analyze the stability conditions of either uniformly mixed or phase segregated steady states consisting of phases enriched…

Statistical Mechanics · Physics 2015-09-21 Alexander Y. Grosberg , Jean-François Joanny

The motility-induced phase separation (MIPS) is the spontaneous aggregation of active particles, while equilibrium phase separation (EPS) is thermodynamically driven by attractive interactions between passive particles. Despite such…

Statistical Mechanics · Physics 2020-12-07 Kyosuke Adachi , Kyogo Kawaguchi

We study the thermodynamics of binary mixtures with the volume fraction of the minority component less than the amount required to form a flat interface and show that the surface tension dominated equilibrium phase of the mixture forms a…

Soft Condensed Matter · Physics 2023-03-07 Subhadip Biswas , Biswaroop Mukherjee , Buddhapriya Chakrabarti

We report numerical results for the hydrodynamics of inhomogeneous lyotropic and extensile active nematic gels. By simulating the coupled Cahn-Hilliard, Navier-Stokes, and Beris-Edwards equation for the evolution of the composition, flow…

Soft Condensed Matter · Physics 2023-01-06 Renato Assante , Dom Corbett , Davide Marenduzzo , Alexander Morozov

The phase behavior is investigated for systems composed of a large number of macromolecular components N, with N greater or equal to 2. Liquid-liquid phase separation is modelled using a virial expansion up to the second order of the…

Soft Condensed Matter · Physics 2024-05-29 Arjen Bot , Erik van der Linden , Paul Venema

Proliferation and motility are ubiquitous drivers of activity in biological systems. Here, we study a dense binary mixture of motile and proliferating particles with exclusively repulsive interactions, where homeostasis in the proliferating…

Soft Condensed Matter · Physics 2025-06-11 Lukas Hupe , Joanna M. Materska , David Zwicker , Ramin Golestanian , Bartlomiej Waclaw , Philip Bittihn

Technical challenges in molecule sensing and chemical detection have created an increasing demand for transformative materials with high sensitivity and specificity. Biohybrid nanopores have attracted growing interest as they can ideally…

Biological Physics · Physics 2022-04-05 Francois Sicard , A. Ozgur Yazaydin

This paper extends our earlier studies of free energy functions of density and crystalline order parameters for models of supercooled water, which allows us to examine the possibility of two distinct metastable liquid phases [J. Chem. Phys.…

Statistical Mechanics · Physics 2015-06-15 David T. Limmer , David Chandler

Whether live cell membranes show miscibility phase transitions (MPTs), and if so, how they fluctuate near the transitions remain outstanding unresolved issues in physics and biology alike. Motivated by these questions we construct a generic…

Soft Condensed Matter · Physics 2017-12-01 Tirthankar Banerjee , Abhik Basu

Biomolecular condensates such as membraneless organelles, underpinned by liquid-liquid phase separation (LLPS), are important for physiological function, with electrostatics -- among other interaction types -- being a prominent force in…

Biomolecules · Quantitative Biology 2021-05-26 Jonas Wessén , Tanmoy Pal , Suman Das , Yi-Hsuan Lin , Hue Sun Chan

We consider mixtures of two species of spherical colloidal particles that differ in their hydrodynamic radii, but are otherwise identical, in the presence of an external field. Since the particle-particle and particle-field interactions are…

Soft Condensed Matter · Physics 2018-09-26 André S. Nunes , Akshat Gupta , Nuno A. M. Araújo , Margarida M. Telo da Gama

A relativistic mean-field model of nuclear matter with arbitrary proton fraction is studied at finite temperature. An analysis is performed of the liquid-gas phase transition in a system with two conserved charges (baryon number and…

Nuclear Theory · Physics 2008-11-26 Horst Mueller , Brian D. Serot

Nucleation and growth (N&G) - the emergence of a new phase within an initially homogeneous one - is one of the most important physical phenomena by which gas-liquid, liquid-liquid and solid-liquid phase separation takes place. Accordingly,…

Soft Condensed Matter · Physics 2022-03-23 Hamed Almohammadi , Sandra Martinek , Ye Yuan , Peter Fischer , Raffaele Mezzenga

If a binary liquid mixture, composed of two alternative species with equal amounts, is quenched from a high temperature to a low temperature, below the critical point of demixing, then the mixture will phase separate through a process known…

Statistical Mechanics · Physics 2022-02-04 Thomas J. Longo , Mikhail A. Anisimov

Understanding how microscopic motility shapes emergent collective behaviors is a challenging task in active matter, especially when self-propulsion is regulated by external cues or via quorum-sensing interactions. To address this problem,…

Statistical Mechanics · Physics 2026-04-13 Alberto Dinelli , Pietro Luigi Muzzeddu

Dense active systems are widespread in nature, examples range from bacterial colonies to biological tissues. Dense clusters of active particles can be obtained by increasing the packing fraction of the system or taking advantage of a…

Soft Condensed Matter · Physics 2022-04-13 Matteo Paoluzzi , Demian Levis , Ignacio Pagonabarraga
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